(data stored in SCRATCH zone)

SWISSPROT: Q6FJQ1_CANGA

ID   Q6FJQ1_CANGA            Unreviewed;       469 AA.
AC   Q6FJQ1;
DT   19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2004, sequence version 1.
DT   08-MAY-2019, entry version 82.
DE   RecName: Full=Proline dehydrogenase {ECO:0000256|RuleBase:RU364054};
DE            EC=1.5.5.2 {ECO:0000256|RuleBase:RU364054};
GN   OrderedLocusNames=CAGL0M04499g {ECO:0000313|CGD:CAL0137033,
GN   ECO:0000313|EMBL:CAG62519.1};
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593 {ECO:0000313|Proteomes:UP000002428};
RN   [1] {ECO:0000313|EMBL:CAG62519.1, ECO:0000313|Proteomes:UP000002428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC   {ECO:0000313|Proteomes:UP000002428};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.F., Straub M.L., Suleau A.,
RA   Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate.
CC       {ECO:0000256|RuleBase:RU364054}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a
CC         quinol + H(+); Xref=Rhea:RHEA:23784, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17388, ChEBI:CHEBI:24646, ChEBI:CHEBI:60039,
CC         ChEBI:CHEBI:132124; EC=1.5.5.2;
CC         Evidence={ECO:0000256|RuleBase:RU364054};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU364054};
CC   -!- SIMILARITY: Belongs to the proline oxidase family.
CC       {ECO:0000256|RuleBase:RU364054}.
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DR   EMBL; CR380959; CAG62519.1; -; Genomic_DNA.
DR   RefSeq; XP_449543.1; XM_449543.1.
DR   STRING; 5478.XP_449543.1; -.
DR   EnsemblFungi; CAG62519; CAG62519; CAGL0M04499g.
DR   GeneID; 2891552; -.
DR   KEGG; cgr:CAGL0M04499g; -.
DR   CGD; CAL0137033; CAGL0M04499g.
DR   EuPathDB; FungiDB:CAGL0M04499g; -.
DR   eggNOG; KOG0186; Eukaryota.
DR   eggNOG; COG0506; LUCA.
DR   HOGENOM; HOG000248390; -.
DR   InParanoid; Q6FJQ1; -.
DR   KO; K00318; -.
DR   OMA; KYVPWGP; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR   GO; GO:0004657; F:proline dehydrogenase activity; IEA:EnsemblFungi.
DR   GO; GO:0010133; P:proline catabolic process to glutamate; IEA:EnsemblFungi.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR002872; Proline_DH_dom.
DR   InterPro; IPR015659; Proline_oxidase.
DR   PANTHER; PTHR13914; PTHR13914; 1.
DR   Pfam; PF01619; Pro_dh; 1.
DR   SUPFAM; SSF51730; SSF51730; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJQ1.
DR   SWISS-2DPAGE; Q6FJQ1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002428};
KW   FAD {ECO:0000256|RuleBase:RU364054};
KW   Flavoprotein {ECO:0000256|RuleBase:RU364054};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU364054};
KW   Proline metabolism {ECO:0000256|RuleBase:RU364054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002428}.
FT   DOMAIN      117    449       Pro_dh. {ECO:0000259|Pfam:PF01619}.
SQ   SEQUENCE   469 AA;  52426 MW;  889D68A9FF657789 CRC64;
     MLRIYRPRVM AIARRYVSQT AQTSNAMVAD TTDPMMNPMQ PKLSSHSQLP PSSVAYLKTL
     SRAEVFSLGM IGLATTSKPV LNLVIKLFPY VPMPLIKMFV SRLYCGGDNI NEVKTFGEKL
     QKRGISNMML SLTIEDSEGT KNIDINYIVE ETIKSVHGVL KPNLVNQLEK CGNDAKKINE
     IAPGYIALKP SALVSNPHDV LMNFNNPDPH WVAQREKLID NCSRIAQEIY DLNNDLLKKY
     PSRTAPFCVA TIDAEKYDLQ NSGVYELQRI LFQKFNKLSS PMVSVIGTWQ LYLVDSAAQL
     AREHARAMKE GYKLGVKLVR GAYIHSETKR DSIIFKTKEG TDENYDAVMT TVIQDLLKNG
     TKSYYGHLVV ASHNYGSQML ATKILKDAPE NVGKANIVLG QLLGMSDNVT HDLITKHGAK
     NIIKYVPWGP PLETKDYLLR RLQENGDAVK SDNGFPLVKA VIKSLFSRA
//

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