(data stored in ACNUC9552 zone)

SWISSPROT: Q6GLI5_XENTR

ID   Q6GLI5_XENTR            Unreviewed;       201 AA.
AC   Q6GLI5;
DT   19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2004, sequence version 1.
DT   05-JUL-2017, entry version 89.
DE   SubName: Full=BCL2-like 1 {ECO:0000313|EMBL:AAH74505.1, ECO:0000313|Ensembl:ENSXETP00000053903};
GN   Name=bcl2l1 {ECO:0000313|EMBL:AAH74505.1,
GN   ECO:0000313|Ensembl:ENSXETP00000053903,
GN   ECO:0000313|Xenbase:XB-GENE-481317};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH74505.1};
RN   [1] {ECO:0000313|EMBL:AAH74505.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH74505.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000053903}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000053903};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [3] {ECO:0000313|Ensembl:ENSXETP00000053903}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
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DR   EMBL; AAMC01172223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC074505; AAH74505.1; -; mRNA.
DR   RefSeq; NP_001005428.1; NM_001005428.1.
DR   UniGene; Str.24470; -.
DR   STRING; 8364.ENSXETP00000053903; -.
DR   Ensembl; ENSXETT00000053903; ENSXETP00000053903; ENSXETG00000025175.
DR   GeneID; 447991; -.
DR   KEGG; xtr:447991; -.
DR   CTD; 598; -.
DR   Xenbase; XB-GENE-481317; bcl2l1.
DR   eggNOG; KOG4728; Eukaryota.
DR   eggNOG; ENOG41123S0; LUCA.
DR   GeneTree; ENSGT00530000062935; -.
DR   HOGENOM; HOG000056452; -.
DR   HOVERGEN; HBG004472; -.
DR   KO; K04570; -.
DR   OMA; ANKEMTE; -.
DR   OrthoDB; EOG091G0OCU; -.
DR   TreeFam; TF315834; -.
DR   Reactome; R-XTR-111453; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
DR   Reactome; R-XTR-844455; The NLRP1 inflammasome.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000025175; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Ensembl.
DR   GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR   GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
DR   GO; GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR   GO; GO:0001894; P:tissue homeostasis; IEA:Ensembl.
DR   InterPro; IPR013279; Apop_reg_BclX.
DR   InterPro; IPR002475; Bcl2-like.
DR   InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR   InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR   InterPro; IPR003093; Bcl2_BH4.
DR   InterPro; IPR026298; Blc2_fam.
DR   PANTHER; PTHR11256; PTHR11256; 1.
DR   PANTHER; PTHR11256:SF61; PTHR11256:SF61; 1.
DR   Pfam; PF00452; Bcl-2; 1.
DR   Pfam; PF02180; BH4; 1.
DR   PRINTS; PR01864; APOPREGBCLX.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   SMART; SM00265; BH4; 1.
DR   SUPFAM; SSF56854; SSF56854; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS01080; BH1; 1.
DR   PROSITE; PS01258; BH2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q6GLI5.
DR   SWISS-2DPAGE; Q6GLI5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     26       BH4_2. {ECO:0000259|SMART:SM00265}.
SQ   SEQUENCE   201 AA;  22335 MW;  EEFF0B533BBF7EA5 CRC64;
     MEGSSRDLVE KFVCKKLSQK GACGEFSSNS QPKGVSNGSS EGPGATQGIV GEEVLQALLD
     ASEEFELRYQ RAFSDLTAQL HLTQDTAQQS FQQVVGELFR DGTNWGRIVA FFSFGRALCV
     ESANKEMTEL LPRIVQWMVQ YLEHTLQPWM LENGGWEAFV GLYGKGAAAQ SREGPERFGR
     WLMAIVTVTA ATLLVSYLRR R
//

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