(data stored in ACNUC15260 zone)

SWISSPROT: OR6B2_HUMAN

ID   OR6B2_HUMAN             Reviewed;         312 AA.
AC   Q6IFH4; B2RPR3; Q8NGW0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 2.
DT   08-MAY-2019, entry version 120.
DE   RecName: Full=Olfactory receptor 6B2;
DE   AltName: Full=Olfactory receptor OR2-1;
GN   Name=OR6B2; Synonyms=OR6B2P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DAA04686.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
CC       (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6B2";
DR   EMBL; AB065663; BAC05889.1; -; Genomic_DNA.
DR   EMBL; CH471063; EAW71176.1; -; Genomic_DNA.
DR   EMBL; BC137561; AAI37562.1; -; mRNA.
DR   EMBL; BC137562; AAI37563.1; -; mRNA.
DR   EMBL; BK004288; DAA04686.1; ALT_INIT; Genomic_DNA.
DR   CCDS; CCDS46559.1; -.
DR   RefSeq; NP_001005853.1; NM_001005853.1.
DR   STRING; 9606.ENSP00000384563; -.
DR   BioMuta; OR6B2; -.
DR   DMDM; 84029382; -.
DR   PaxDb; Q6IFH4; -.
DR   PeptideAtlas; Q6IFH4; -.
DR   PRIDE; Q6IFH4; -.
DR   ProteomicsDB; 66424; -.
DR   Ensembl; ENST00000402971; ENSP00000384563; ENSG00000182083.
DR   GeneID; 389090; -.
DR   KEGG; hsa:389090; -.
DR   UCSC; uc010zoc.3; human.
DR   CTD; 389090; -.
DR   GeneCards; OR6B2; -.
DR   HGNC; HGNC:15041; OR6B2.
DR   HPA; HPA047529; -.
DR   neXtProt; NX_Q6IFH4; -.
DR   PharmGKB; PA32577; -.
DR   eggNOG; ENOG410IKF0; Eukaryota.
DR   eggNOG; ENOG41113GD; LUCA.
DR   GeneTree; ENSGT00950000182871; -.
DR   HOGENOM; HOG000041364; -.
DR   InParanoid; Q6IFH4; -.
DR   KO; K04257; -.
DR   OMA; VVTPIIN; -.
DR   OrthoDB; 950937at2759; -.
DR   PhylomeDB; Q6IFH4; -.
DR   TreeFam; TF337475; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   GeneWiki; OR6B2; -.
DR   GenomeRNAi; 389090; -.
DR   PRO; PR:Q6IFH4; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000182083; Expressed in 12 organ(s), highest expression level in tibial nerve.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q6IFH4.
DR   SWISS-2DPAGE; Q6IFH4.
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
KW   Polymorphism; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    312       Olfactory receptor 6B2.
FT                                /FTId=PRO_0000150621.
FT   TOPO_DOM      1     25       Extracellular. {ECO:0000255}.
FT   TRANSMEM     26     46       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     47     54       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     55     75       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     76     99       Extracellular. {ECO:0000255}.
FT   TRANSMEM    100    120       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    121    139       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    140    160       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    161    196       Extracellular. {ECO:0000255}.
FT   TRANSMEM    197    217       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    218    237       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    238    258       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    259    271       Extracellular. {ECO:0000255}.
FT   TRANSMEM    272    292       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    293    312       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD      5      5       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     97    189       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   VARIANT     179    179       C -> R (in dbSNP:rs10187574).
FT                                /FTId=VAR_062047.
FT   VARIANT     227    227       R -> C (in dbSNP:rs60841887).
FT                                /FTId=VAR_062048.
SQ   SEQUENCE   312 AA;  35029 MW;  56D388B1AF4799FA CRC64;
     MSGENVTKVS TFILVGLPTA PGLQYLLFLL FLLTYLFVLV ENLAIILIVW SSTSLHRPMY
     YFLSSMSFLE IWYVSDITPK MLEGFLLQQK RISFVGCMTQ LYFFSSLVCT ECVLLASMAY
     DRYVAICHPL RYHVLVTPGL CLQLVGFSFV SGFTISMIKV CFISSVTFCG SNVLNHFFCD
     ISPILKLACT DFSTAELVDF ILAFIILVFP LLATILSYWH ITLAVLRIPS ATGCWRAFST
     CASHLTVVTV FYTALLFMYV RPQAIDSQSS NKLISAVYTV VTPIINPLIY CLRNKEFKDA
     LKKALGLGQT SH
//

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