(data stored in SCRATCH zone)

SWISSPROT: Q6NYJ9_DANRE

ID   Q6NYJ9_DANRE            Unreviewed;       951 AA.
AC   Q6NYJ9; A0A0R4IC49; B0R152;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   08-MAY-2019, entry version 123.
DE   RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN   Name=ap2b1 {ECO:0000313|EMBL:AAH66566.1,
GN   ECO:0000313|Ensembl:ENSDARP00000132587,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-6564};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH66566.1};
RN   [1] {ECO:0000313|EMBL:AAH66566.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000313|EMBL:AAH66566.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000132587, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000132587,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000132587}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000132587};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000151953}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000151953};
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00556307}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|PIRNR:PIRNR002291}.
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DR   EMBL; AL935280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU570899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC066566; AAH66566.1; -; mRNA.
DR   RefSeq; NP_956213.2; NM_199919.2.
DR   STRING; 7955.ENSDARP00000050915; -.
DR   Ensembl; ENSDART00000171248; ENSDARP00000132587; ENSDARG00000035152.
DR   Ensembl; ENSDART00000188878; ENSDARP00000151953; ENSDARG00000035152.
DR   GeneID; 334632; -.
DR   KEGG; dre:334632; -.
DR   CTD; 163; -.
DR   ZFIN; ZDB-GENE-030131-6564; ap2b1.
DR   eggNOG; KOG1061; Eukaryota.
DR   eggNOG; COG5096; LUCA.
DR   GeneTree; ENSGT00940000155206; -.
DR   HOGENOM; HOG000163270; -.
DR   KO; K11825; -.
DR   OrthoDB; 323029at2759; -.
DR   TreeFam; TF300318; -.
DR   Reactome; R-DRE-2132295; MHC class II antigen presentation.
DR   Reactome; R-DRE-3928665; EPH-ephrin mediated repulsion of cells.
DR   Reactome; R-DRE-416993; Trafficking of GluR2-containing AMPA receptors.
DR   Reactome; R-DRE-437239; Recycling pathway of L1.
DR   Reactome; R-DRE-5099900; WNT5A-dependent internalization of FZD4.
DR   Reactome; R-DRE-5140745; WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
DR   Reactome; R-DRE-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DRE-8856828; Clathrin-mediated endocytosis.
DR   Reactome; R-DRE-8866427; VLDLR internalisation and degradation.
DR   Reactome; R-DRE-8964038; LDL clearance.
DR   Proteomes; UP000000437; Chromosome 5.
DR   Bgee; ENSDARG00000035152; Expressed in 28 organ(s), highest expression level in brain.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 2.60.40.1150; -; 1.
DR   Gene3D; 3.30.310.10; -; 1.
DR   InterPro; IPR026739; AP_beta.
DR   InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR015151; B-adaptin_app_sub_C.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR   InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR   InterPro; IPR013037; Clathrin_b-adaptin_app_Ig-like.
DR   InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR11134; PTHR11134; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF02883; Alpha_adaptinC2; 1.
DR   Pfam; PF09066; B2-adapt-app_C; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SMART; SM00809; Alpha_adaptinC2; 1.
DR   SMART; SM00185; ARM; 2.
DR   SMART; SM01020; B2-adapt-app_C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49348; SSF49348; 1.
DR   SUPFAM; SSF55711; SSF55711; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q6NYJ9.
DR   SWISS-2DPAGE; Q6NYJ9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00468874};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00299732};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q6NYJ9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transport {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00468876}.
FT   DOMAIN      721    831       Alpha_adaptinC2. {ECO:0000259|SMART:
FT                                SM00809}.
FT   DOMAIN      840    950       B2-adapt-app_C. {ECO:0000259|SMART:
FT                                SM01020}.
SQ   SEQUENCE   951 AA;  105625 MW;  78D04ED39654D05C CRC64;
     MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL FPDVVNCMQT
     DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP LIRALAVRTM GCIRVDKITE
     YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQMVEDQG FLDSLRDLIA DSNPMVVANA
     VAALSEISES HPNSNLLDLN PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDEREAQSI
     CERVTPRLSH ANSAVVLSAV KVLMKFLELL PKDSDYYNTL LKKLSPPLVT LLSGEPEVQY
     VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASHAN IAQVLAELKE
     YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIRDIFRK
     YPNKYESIIA TLCENLDSLD EPDARGAMIW IVGEYAERID NADELLESFL EGFHDESTQV
     QLTLLTAIVK LFLKKPSETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV
     VLSEKPLISE ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIQHGSI
     DTGESPVSTG PAASIDQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQI AAVDLLGGGL
     DSLLGGDLGG GVGGSPAVGQ NFIPSSVPNT FAPSPTPAAL SSGLNDLFEL STGMATATGG
     YVAAKTVWLP AVKAKGLEIS GTFSRRQGHM YMDMTFTNKA LQHMTDFAIQ FNKNSFGVIP
     TTPLPVHTPL MPSQSIDISL PLNTIGPVMK MDPLNNLQVA VKNNIDVFYF STLIPLNVFF
     VEDGKMERQV FLATWKDIPN ENELQYQIKD CHLNADTVSG KLQSNNVYTI AKRNVEGQDM
     LYQSLKLTNG IWILAELRIQ PGNPNYTLSL KCRAPEVSQY VYQMYDATLK N
//

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