(data stored in ACNUC1829 zone)

SWISSPROT: Q6PFU1_DANRE

ID   Q6PFU1_DANRE            Unreviewed;       236 AA.
AC   Q6PFU1;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   07-JUN-2017, entry version 90.
DE   RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
GN   Name=cd81a {ECO:0000313|Ensembl:ENSDARP00000052382,
GN   ECO:0000313|ZFIN:ZDB-GENE-000831-5};
GN   Synonyms=cd81 {ECO:0000313|EMBL:AAH57419.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH57419.1};
RN   [1] {ECO:0000313|EMBL:AAH57419.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000313|EMBL:AAH57419.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000052382}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000052382};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000052382, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000052382,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361218};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361218}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|RuleBase:RU361218, ECO:0000256|SAAS:SAAS00545671}.
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DR   EMBL; CU570985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC057419; AAH57419.1; -; mRNA.
DR   RefSeq; NP_571593.2; NM_131518.2.
DR   UniGene; Dr.75855; -.
DR   STRING; 7955.ENSDARP00000052382; -.
DR   Ensembl; ENSDART00000052383; ENSDARP00000052382; ENSDARG00000036080.
DR   GeneID; 58031; -.
DR   KEGG; dre:58031; -.
DR   CTD; 58031; -.
DR   ZFIN; ZDB-GENE-000831-5; cd81a.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00880000137858; -.
DR   HOGENOM; HOG000230651; -.
DR   HOVERGEN; HBG002324; -.
DR   KO; K06508; -.
DR   OMA; FEMIFSM; -.
DR   OrthoDB; EOG091G0K9H; -.
DR   TreeFam; TF352895; -.
DR   Proteomes; UP000000437; Chromosome 7.
DR   Bgee; ENSDARG00000036080; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q6PFU1.
DR   SWISS-2DPAGE; Q6PFU1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00027997};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q6PFU1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00429797};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00028005}.
FT   TRANSMEM     12     37       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM     58     86       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM     92    115       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM    204    226       Helical. {ECO:0000256|RuleBase:RU361218}.
SQ   SEQUENCE   236 AA;  26198 MW;  57F4D263903E443C CRC64;
     MGVGVEGCTK CIKYMLFFFN FIFWLAGCVI LGVSLWLRHD TKTSSLLDLK YEGTESPTTF
     YISVYILIAV GAVMMFVGFL GCYGAIQESQ CLLGTFFACL VLLFACEVAA GIWGFMNKDK
     ISKEVIGFYD SVYDKGATYN TDNKNPATAV LKVFHETLQC CGKGNLFTAI VDRWLTDTCP
     EHLRTNAVDC HTEIKNLFTD KISLIGIAAL VVAVIMIFEM IFSMVLCCGI RNSPVY
//

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