(data stored in ACNUC23405 zone)

SWISSPROT: Q6SYZ1_DANRE

ID   Q6SYZ1_DANRE            Unreviewed;       311 AA.
AC   Q6SYZ1;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 131.
DE   SubName: Full=Homeodomain protein Hb9 {ECO:0000313|EMBL:AAS07018.1};
DE   SubName: Full=Motor neuron and pancreas homeobox 1 {ECO:0000313|EMBL:AAH93243.1, ECO:0000313|Ensembl:ENSDARP00000052235};
GN   Name=mnx1 {ECO:0000313|EMBL:AAH93243.1,
GN   ECO:0000313|Ensembl:ENSDARP00000052235,
GN   ECO:0000313|ZFIN:ZDB-GENE-040409-1};
GN   Synonyms=hb9 {ECO:0000313|EMBL:AAS07018.1}, hlxb9
GN   {ECO:0000313|ZFIN:ZDB-GENE-040409-1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000313|EMBL:AAS07018.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15063174; DOI=10.1016/j.ydbio.2003.12.026;
RA   Wendik B., Maier E., Meyer D.;
RT   "Zebrafish mnx genes in endocrine and exocrine pancreas formation.";
RL   Dev. Biol. 268:372-383(2004).
RN   [2] {ECO:0000313|EMBL:AAH93243.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larvae {ECO:0000313|EMBL:AAH93243.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000052235}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000052235};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000052235, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000052235,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
CC       ProRule:PRU00108, ECO:0000256|RuleBase:RU000682,
CC       ECO:0000256|SAAS:SAAS00544279}.
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DR   EMBL; BX247878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC093243; AAH93243.1; -; mRNA.
DR   EMBL; AY445044; AAS07018.1; -; mRNA.
DR   RefSeq; NP_001009885.1; NM_001009885.2.
DR   UniGene; Dr.91917; -.
DR   STRING; 7955.ENSDARP00000052235; -.
DR   Ensembl; ENSDART00000052236; ENSDARP00000052235; ENSDARG00000035984.
DR   GeneID; 405399; -.
DR   KEGG; dre:405399; -.
DR   CTD; 3110; -.
DR   ZFIN; ZDB-GENE-040409-1; mnx1.
DR   eggNOG; KOG0489; Eukaryota.
DR   eggNOG; ENOG410ZTBY; LUCA.
DR   GeneTree; ENSGT00760000118940; -.
DR   HOGENOM; HOG000234345; -.
DR   HOVERGEN; HBG051910; -.
DR   KO; K08025; -.
DR   OMA; AGMMLPK; -.
DR   OrthoDB; EOG091G0PFO; -.
DR   TreeFam; TF351530; -.
DR   Proteomes; UP000000437; Chromosome 7.
DR   Bgee; ENSDARG00000035984; -.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0031018; P:endocrine pancreas development; IGI:ZFIN.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
DR   GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IGI:ZFIN.
DR   GO; GO:0003309; P:type B pancreatic cell differentiation; IMP:ZFIN.
DR   InterPro; IPR009057; Homeobox-like.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeobox; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q6SYZ1.
DR   SWISS-2DPAGE; Q6SYZ1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00022856,
KW   ECO:0000313|EMBL:AAH93243.1};
KW   Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00022921,
KW   ECO:0000313|EMBL:AAS07018.1};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00427283};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN      175    235       Homeobox DNA-binding.
FT                                {ECO:0000259|PROSITE:PS50071}.
FT   DNA_BIND    177    236       Homeobox. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00108}.
SQ   SEQUENCE   311 AA;  34662 MW;  04B1729BABD1CF61 CRC64;
     MEKSKNFRID ALLAVDPPKV QTSPLALVTS LPTSSISSSS DSVQAVELTT NSDALQTESP
     SPPRISSCGL IPKPGFLNSP HSGMVGLHPQ SSTGIPPQAL YGHPMYTYSA AALGQHPALS
     YSYPHGSHHH HHPSDPLKLT ASSFQLDHWL RVSTAGMMLP KMADFNGQAQ SNLLGKCRRP
     RTAFTSQQLL ELEHQFKLNK YLSRPKRFEV ATSLMLTETQ VKIWFQNRRM KWKRSKKAKE
     QAAQDAEKQK GKGNHDKMDG LEKDYQKVDS GKSNRIRDFR DSDDEEGDNY MLNSSDCSSE
     DERTNDISPQ P
//

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