(data stored in SCRATCH zone)

SWISSPROT: Q750R0_ASHGO

ID   Q750R0_ASHGO            Unreviewed;       414 AA.
AC   Q750R0;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 101.
DE   SubName: Full=AGL118Wp {ECO:0000313|EMBL:AAS54373.1};
GN   ORFNames=AGOS_AGL118W {ECO:0000313|EMBL:AAS54373.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS54373.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS54373.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
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DR   EMBL; AE016820; AAS54373.1; -; Genomic_DNA.
DR   RefSeq; NP_986549.1; NM_211611.1.
DR   STRING; 33169.AAS54373; -.
DR   EnsemblFungi; AAS54373; AAS54373; AGOS_AGL118W.
DR   GeneID; 4622848; -.
DR   KEGG; ago:AGOS_AGL118W; -.
DR   HOGENOM; HOG000111204; -.
DR   InParanoid; Q750R0; -.
DR   KO; K11121; -.
DR   OMA; AGTSCKI; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005677; C:chromatin silencing complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031934; C:mating-type region heterochromatin; IEA:EnsemblFungi.
DR   GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR   GO; GO:0000790; C:nuclear chromatin; IBA:GO_Central.
DR   GO; GO:0005720; C:nuclear heterochromatin; IBA:GO_Central.
DR   GO; GO:0031618; C:nuclear pericentric heterochromatin; IBA:GO_Central.
DR   GO; GO:1902377; C:nuclear rDNA heterochromatin; IEA:EnsemblFungi.
DR   GO; GO:1990707; C:nuclear subtelomeric heterochromatin; IEA:EnsemblFungi.
DR   GO; GO:0005724; C:nuclear telomeric heterochromatin; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0034967; C:Set3 complex; IBA:GO_Central.
DR   GO; GO:0070403; F:NAD+ binding; IBA:GO_Central.
DR   GO; GO:0017136; F:NAD-dependent histone deacetylase activity; IBA:GO_Central.
DR   GO; GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IBA:GO_Central.
DR   GO; GO:1990383; P:cellular response to biotin starvation; IEA:EnsemblFungi.
DR   GO; GO:0030702; P:chromatin silencing at centromere; IEA:EnsemblFungi.
DR   GO; GO:0006348; P:chromatin silencing at telomere; IEA:EnsemblFungi.
DR   GO; GO:0071572; P:histone H3-K56 deacetylation; IEA:EnsemblFungi.
DR   GO; GO:1990679; P:histone H4-K12 deacetylation; IEA:EnsemblFungi.
DR   GO; GO:1990678; P:histone H4-K16 deacetylation; IEA:EnsemblFungi.
DR   GO; GO:0009299; P:mRNA transcription; IEA:EnsemblFungi.
DR   GO; GO:0098781; P:ncRNA transcription; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0006282; P:regulation of DNA repair; IEA:EnsemblFungi.
DR   GO; GO:0060303; P:regulation of nucleosome density; IEA:EnsemblFungi.
DR   GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IEA:EnsemblFungi.
DR   GO; GO:0046459; P:short-chain fatty acid metabolic process; IEA:EnsemblFungi.
DR   Gene3D; 3.30.1600.10; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   4: Predicted;
DR   PRODOM; Q750R0.
DR   SWISS-2DPAGE; Q750R0.
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   DOMAIN          121..414
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
FT   REGION          46..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..65
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  45732 MW;  E5AB2EC8C3DD5CDD CRC64;
     MSATRHAAGQ PRVQQAAEVC GTCGMTEATG GIGVKRYRSP MKVKLPITPP SSVKKKQTEA
     CDSGPSVSEE VTPKELLPAL RKARAPVRRK PRLTYRPATN SVFQLAHYVS DPELVSARDA
     DFIRYALQHS RDIVVVTGAG ISVAAGIPDF RSSDGLFATL RGGKVKSGKH LFDFNHVYSS
     DDMSMQFNRM IVDIHGKSQR FEPTEFHRLL DGLAQQGRVR RIYTQNIDCL ENKLANISSL
     QTGPKQVPKT IQLHGSINHM CCNKCRKIYD MDPTLFKCGD NDTTGDVIPV CPECEELEAV
     RRIAGKREQG VGKLRPYIVL YNEVHPEGEK VGEIVAKDLR LKCDCLIIVG TSLQIPGVKT
     ICRQFCQAVR ARKGIVLWVN KELPTQAIQD FLGGMDLIIV GDCQDLTTLA PSFN
//

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