(data stored in SCRATCH zone)

SWISSPROT: Q750Z7_ASHGO

ID   Q750Z7_ASHGO            Unreviewed;       367 AA.
AC   Q750Z7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 111.
DE   RecName: Full=Uroporphyrinogen decarboxylase {ECO:0000256|RuleBase:RU000554};
DE            EC=4.1.1.37 {ECO:0000256|RuleBase:RU000554};
GN   ORFNames=AGOS_AGL210C {ECO:0000313|EMBL:AAS54281.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS54281.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS54281.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen
CC         III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57308, ChEBI:CHEBI:57309; EC=4.1.1.37;
CC         Evidence={ECO:0000256|RuleBase:RU000554};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC       {ECO:0000256|RuleBase:RU000554}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC       {ECO:0000256|RuleBase:RU004169}.
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DR   EMBL; AE016820; AAS54281.1; -; Genomic_DNA.
DR   RefSeq; NP_986457.1; NM_211519.1.
DR   STRING; 33169.AAS54281; -.
DR   EnsemblFungi; AAS54281; AAS54281; AGOS_AGL210C.
DR   GeneID; 4622750; -.
DR   KEGG; ago:AGOS_AGL210C; -.
DR   HOGENOM; HOG000253896; -.
DR   InParanoid; Q750Z7; -.
DR   KO; K01599; -.
DR   OMA; PHIFNLG; -.
DR   UniPathway; UPA00251; UER00321.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IBA:GO_Central.
DR   GO; GO:0006783; P:heme biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00717; URO-D; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   HAMAP; MF_00218; URO_D; 1.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR   InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR   Pfam; PF01208; URO-D; 1.
DR   SUPFAM; SSF51726; SSF51726; 1.
DR   TIGRFAMs; TIGR01464; hemE; 1.
DR   PROSITE; PS00906; UROD_1; 1.
DR   PROSITE; PS00907; UROD_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q750Z7.
DR   SWISS-2DPAGE; Q750Z7.
KW   Decarboxylase {ECO:0000256|RuleBase:RU000554};
KW   Lyase {ECO:0000256|RuleBase:RU000554};
KW   Porphyrin biosynthesis {ECO:0000256|RuleBase:RU000554};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   DOMAIN          30..39
FT                   /note="Uroporphyrinogen_deCOase"
FT                   /evidence="ECO:0000259|PROSITE:PS00906"
FT   DOMAIN          153..169
FT                   /note="Uroporphyrinogen_deCOase"
FT                   /evidence="ECO:0000259|PROSITE:PS00907"
SQ   SEQUENCE   367 AA;  41573 MW;  57765E547D0256B5 CRC64;
     MQAVDRTQFA PLKNDLMLRA ARGEDVERPP CWIMRQAGRY LPEYHDVKGG RDFFETCRDA
     EIASEITLQP VRRYAGLLDA AIIFSDILVI PQAMGMRVEM LEGKGPHFPE PLRTTEQLMK
     VLEYEVDVLR ELDWAFRAIT LTRQKLAGDV PLFGFCGGPW TLLVYMTEGG GSRLFRFAKE
     WIHKRPELAH KLLQKITDVA IEFLAQQVVA GCQILQVFES WGGELSPADF DEFSLPYLKQ
     IAAAVPARLR ELGITEDVPM TVFAKGSWYA LDKLCDAGYN TVSLDWLWDP AEAVRINNGR
     VTLQGNLDPT VMYGSDETIT KKTEAMIKGF GGGKKQYIVN FGHGTHPFMD PEKIRHFLEE
     CHRIGKM
//

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