(data stored in SCRATCH zone)

SWISSPROT: Q751F8_ASHGO

ID   Q751F8_ASHGO            Unreviewed;       795 AA.
AC   Q751F8;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 89.
DE   RecName: Full=Probable vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|PIRNR:PIRNR007949};
GN   ORFNames=AGOS_AGL252W {ECO:0000313|EMBL:AAS54239.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS54239.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS54239.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Essential for vacuolar protein sorting. Required for vacuole
CC       biogenesis, stability and to maintain vacuole morphology.
CC       {ECO:0000256|PIRNR:PIRNR007949}.
CC   -!- SIMILARITY: Belongs to the VPS16 family.
CC       {ECO:0000256|PIRNR:PIRNR007949}.
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DR   EMBL; AE016820; AAS54239.1; -; Genomic_DNA.
DR   RefSeq; NP_986415.1; NM_211477.1.
DR   STRING; 33169.AAS54239; -.
DR   EnsemblFungi; AAS54239; AAS54239; AGOS_AGL252W.
DR   GeneID; 4622708; -.
DR   KEGG; ago:AGOS_AGL252W; -.
DR   HOGENOM; HOG000141904; -.
DR   InParanoid; Q751F8; -.
DR   KO; K20180; -.
DR   OMA; EEYRCIS; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0033263; C:CORVET complex; IEA:EnsemblFungi.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:EnsemblFungi.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   GO; GO:0006895; P:Golgi to endosome transport; IEA:EnsemblFungi.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IEA:EnsemblFungi.
DR   GO; GO:0006623; P:protein targeting to vacuole; IEA:EnsemblFungi.
DR   GO; GO:0035542; P:regulation of SNARE complex assembly; IBA:GO_Central.
DR   GO; GO:0032889; P:regulation of vacuole fusion, non-autophagic; IBA:GO_Central.
DR   GO; GO:0042144; P:vacuole fusion, non-autophagic; IEA:EnsemblFungi.
DR   GO; GO:0099022; P:vesicle tethering; IEA:EnsemblFungi.
DR   Gene3D; 1.10.150.780; -; 1.
DR   InterPro; IPR016534; VPS16.
DR   InterPro; IPR006925; Vps16_C.
DR   InterPro; IPR038132; Vps16_C_sf.
DR   InterPro; IPR006926; Vps16_N.
DR   PANTHER; PTHR12811; PTHR12811; 1.
DR   Pfam; PF04840; Vps16_C; 1.
DR   Pfam; PF04841; Vps16_N; 1.
DR   PIRSF; PIRSF007949; VPS16; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q751F8.
DR   SWISS-2DPAGE; Q751F8.
KW   Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT   DOMAIN          3..373
FT                   /note="Vps16_N"
FT                   /evidence="ECO:0000259|Pfam:PF04841"
FT   DOMAIN          477..786
FT                   /note="Vps16_C"
FT                   /evidence="ECO:0000259|Pfam:PF04840"
SQ   SEQUENCE   795 AA;  91417 MW;  586B586B7A78EC9E CRC64;
     MNPSLGWEKL SDVYYRNRPL CTWDWSHASD LNYSFSLTFC ALHHDQKIHC YNYVGELQWS
     IDCSGLPSEI VNFEFAKNET FILVLEDRIR RYTGWYPLQW EDTMLPDSVS DLIWDYKSGV
     ALLQSSQDIY YYHDSRLELI YQNDDRFTLS TKHHWHTNGG LVVLLDTRVV LHLDIPTRKL
     SHAVAGSWQE VRISPKGFVC LYSMRENSIA IYKDPSRFLL EHSLDVIPDA LEWCGSDTIA
     YCNYKNEEVK LIGPNGSYVA FWFPNPIIAL RTEVDGVKVL TSASINFISK VENYTARIFS
     IGSTESSAIL LDSLELLSNH APRAIENLKV INLEQAVLEC TQAARDEFAP YWQKRLLSAA
     SFGKDSLSNA EFNSQAFVQT CDLLRVLNML SQMGLPLTAK QFDDITIDGV LEILMRLHKF
     HKCIQICSFL NYEKKLGNVF KEWAVAKIKL SPDVDDSALY QSIITQMTNQ GLVPGTSLIQ
     IARAAFLEGR FHLAKKLAVE SPLPRSKLQL LLDMDENELA LSEAVKLLDP ELTLTLLLLL
     RSRLTNAQFT KVLVLVLKDN TLLQFYERNN MVFLYDFYRQ TDRYQELAML IFNDGKKRNA
     LLSFLPQVQN LYGIIDTPLA KENKELISRH ISLVKHQQNL TSLLNYDFTD LTLDATLTQL
     IEMGQERHTS TLVKTFKISE RKYYRIKCRT LVKAGRFDEL NKFAKERKSP IGYKPFYEAV
     FNHGNPREAA VYVSMITGIS NYEKIELYLK CGSFYDAIQL ASREKDIALL QRIKEQLPDN
     QPQLMVVLKE SIAKL
//

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