(data stored in SCRATCH zone)

SWISSPROT: Q751G6_ASHGO

ID   Q751G6_ASHGO            Unreviewed;       513 AA.
AC   Q751G6;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 98.
DE   RecName: Full=Alkaline phosphatase {ECO:0000256|RuleBase:RU003947};
DE            EC=3.1.3.1 {ECO:0000256|RuleBase:RU003947};
GN   ORFNames=AGOS_AGL260W {ECO:0000313|EMBL:AAS54231.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS54231.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS54231.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC         Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.1;
CC         Evidence={ECO:0000256|RuleBase:RU003947};
CC   -!- SIMILARITY: Belongs to the alkaline phosphatase family.
CC       {ECO:0000256|RuleBase:RU003946}.
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DR   EMBL; AE016820; AAS54231.1; -; Genomic_DNA.
DR   RefSeq; NP_986407.1; NM_211469.1.
DR   STRING; 33169.AAS54231; -.
DR   EnsemblFungi; AAS54231; AAS54231; AGOS_AGL260W.
DR   GeneID; 4622700; -.
DR   KEGG; ago:AGOS_AGL260W; -.
DR   HOGENOM; HOG000099116; -.
DR   InParanoid; Q751G6; -.
DR   KO; K01077; -.
DR   OMA; PCGTILE; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004035; F:alkaline phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047386; F:fructose-2,6-bisphosphate 6-phosphatase activity; IEA:EnsemblFungi.
DR   GO; GO:0106219; F:zinc ion sensor activity; IEA:EnsemblFungi.
DR   GO; GO:0046496; P:nicotinamide nucleotide metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006470; P:protein dephosphorylation; IEA:EnsemblFungi.
DR   CDD; cd16012; ALP; 1.
DR   Gene3D; 3.40.720.10; -; 1.
DR   InterPro; IPR001952; Alkaline_phosphatase.
DR   InterPro; IPR018299; Alkaline_phosphatase_AS.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   PANTHER; PTHR11596; PTHR11596; 1.
DR   Pfam; PF00245; Alk_phosphatase; 1.
DR   PRINTS; PR00113; ALKPHPHTASE.
DR   SMART; SM00098; alkPPc; 1.
DR   SUPFAM; SSF53649; SSF53649; 1.
DR   PROSITE; PS00123; ALKALINE_PHOSPHATASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q751G6.
DR   SWISS-2DPAGE; Q751G6.
KW   Hydrolase {ECO:0000256|RuleBase:RU003947};
KW   Magnesium {ECO:0000256|RuleBase:RU003947};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|RuleBase:RU003947}.
FT   TRANSMEM        22..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   513 AA;  56049 MW;  6662D3027AFD0AA7 CRC64;
     MATDEHTGLL PRVGGRSSKQ RAVWGSLVAL LVLATVVLRF DIVPRRAVAG GKRNVIFFVT
     DGMGPASLAM TRAYAQAQET DTQLRLPTFQ MGSMQTRSSS SLITDSAAGA TAFSCAMRTY
     NSAVGVGPDG RPCGTILEAA KLQGYMTGLV VTTRLTDATP AAFSSHVDHR WYEDLIAEHQ
     LGTYPLGRVV DLMIGGGRTH FYGSQDTKYG DGGSRKDGRN LIDKAVEDGW QYVGDMEGFK
     RLQGGHNASL PLLALLADYD IPFDMDRDDA VHPSLEQEMM TAINALTDAT KDSDRGFFLL
     VEGSRIDHAA HQNDPAAQAK EVLAFDRAFM SAVEFAAKSD VETVLISTSD HETGGLTVGR
     QVGTAYPDYV WYPDVLRNAT HSAEYLAHKL VNVPANERED YIREKVLEKG LGIDYYSEED
     LQELVVSRTT DQILDKLTRM VSLRAEIGWS THGHTGVDVN VYAFANTGPS WKSVQDALYG
     NHANVDIGSF LALYLDLDLE KVTDLIKDTK HSP
//

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