(data stored in SCRATCH zone)

SWISSPROT: Q758I7_ASHGO

ID   Q758I7_ASHGO            Unreviewed;       477 AA.
AC   Q758I7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 2.
DT   11-DEC-2019, entry version 87.
DE   RecName: Full=Ribosomal lysine N-methyltransferase 4 {ECO:0000256|PIRNR:PIRNR011771};
DE            EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR011771};
GN   ORFNames=AGOS_AEL225C {ECO:0000313|EMBL:AAS52460.2};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS52460.2, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS52460.2, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent protein-lysine N-
CC       methyltransferase that monomethylates 60S ribosomal protein L42.
CC       {ECO:0000256|PIRNR:PIRNR011771}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR011771}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC       {ECO:0000256|PIRNR:PIRNR011771}.
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DR   EMBL; AE016818; AAS52460.2; -; Genomic_DNA.
DR   RefSeq; NP_984636.2; NM_209989.2.
DR   STRING; 33169.AAS52460; -.
DR   EnsemblFungi; AAS52460; AAS52460; AGOS_AEL225C.
DR   GeneID; 4620818; -.
DR   KEGG; ago:AGOS_AEL225C; -.
DR   HOGENOM; HOG000247886; -.
DR   InParanoid; Q758I7; -.
DR   KO; K05302; -.
DR   OMA; CNANLTY; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; IBA:GO_Central.
DR   InterPro; IPR011383; N-lys_methylase_SETD6.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF011771; RMS1_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q758I7.
DR   SWISS-2DPAGE; Q758I7.
KW   Methyltransferase {ECO:0000256|PIRNR:PIRNR011771};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR011771};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   S-adenosyl-L-methionine {ECO:0000256|PIRNR:PIRNR011771};
KW   Transferase {ECO:0000256|PIRNR:PIRNR011771}.
FT   DOMAIN          19..264
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
SQ   SEQUENCE   477 AA;  52980 MW;  30A882BB8BE03F48 CRC64;
     MVDEFAEATA QFVQWLPKVG IEVAPEVRVE DLRDAGQNRS VVASGAVQEG ATLFTIPRSA
     LLNVHTSALR ECAAGLPAAL EEKIGHWEGL VMCVYYERCV LQERSRWWPC LRLFPAVEEM
     DNLIYWNAEQ RQLLTPSLVG SRIGDESARE MHARVLALAE EWGLSELKEM SWDAFVHIAS
     VIMAYSFDCR LNSDEEDDEE DDDGALDGGT VAADGCIKSI VALAETLNSD THLANANLTY
     DRDQLKMIAV KDIKAGEQVY NLYGSYSNAE LLRRYGYVEW TGSKYDYGEI ELSAIRETIS
     KELAVPDFPF DAVLALLEDK DGWAGELFDY NDIVEESYDC YADGELAPDG AFLVQLLVAL
     AQVPRAALGK GSTLSVRTRK ISKKVMQLLE SGRITRKAAD VLESVIRDRM QAYPPHAAVF
     DGQKPTDLQA MDPAPRREAM ARCVLQCEVK ALQKCALAIS SNYKIISDDL LMGKLLN
//

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