(data stored in SCRATCH zone)

SWISSPROT: Q758J9_ASHGO

ID   Q758J9_ASHGO            Unreviewed;       200 AA.
AC   Q758J9;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 2.
DT   11-DEC-2019, entry version 69.
DE   RecName: Full=Derlin {ECO:0000256|RuleBase:RU363059};
GN   ORFNames=AGOS_AEL237W {ECO:0000313|EMBL:AAS52448.2};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS52448.2, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS52448.2, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: May be involved in the degradation of misfolded endoplasmic
CC       reticulum (ER) luminal proteins. {ECO:0000256|RuleBase:RU363059}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU363059}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363059}.
CC   -!- SIMILARITY: Belongs to the derlin family.
CC       {ECO:0000256|RuleBase:RU363059}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU363059}.
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DR   EMBL; AE016818; AAS52448.2; -; Genomic_DNA.
DR   RefSeq; NP_984624.2; NM_209977.2.
DR   STRING; 33169.AAS52448; -.
DR   EnsemblFungi; AAS52448; AAS52448; AGOS_AEL237W.
DR   GeneID; 4620806; -.
DR   KEGG; ago:AGOS_AEL237W; -.
DR   InParanoid; Q758J9; -.
DR   KO; K13989; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007599; DER1.
DR   Pfam; PF04511; DER1; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q758J9.
DR   SWISS-2DPAGE; Q758J9.
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU363059};
KW   Membrane {ECO:0000256|RuleBase:RU363059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Transmembrane {ECO:0000256|RuleBase:RU363059};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363059}.
FT   TRANSMEM        90..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363059"
FT   TRANSMEM        128..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363059"
FT   TRANSMEM        163..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363059"
SQ   SEQUENCE   200 AA;  23005 MW;  C7CDFCBC2476EC3E CRC64;
     MDVLFVQIMQ GVQPVTRVYV LSMIGCIIAH NIGWIESTKY DFSLIFHRRQ YHKLLLSCFD
     VGSQFNAMDL AITMFQLSYD EQIIGNSKRF IWFIAVVAVL TTSFAYIWDV KGEVLMVDMI
     KWNLTYYAAR TNVAAAGQIG FIRVPSLLAL LRIPIFLRVN QCSFAMCSLS VLPGYVLYLM
     ADAAERLYQI DLMRPPDEWF
//

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