(data stored in SCRATCH zone)

SWISSPROT: Q758S4_ASHGO

ID   Q758S4_ASHGO            Unreviewed;       604 AA.
AC   Q758S4;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 95.
DE   SubName: Full=AEL322Wp {ECO:0000313|EMBL:AAS52362.1};
GN   ORFNames=AGOS_AEL322W {ECO:0000313|EMBL:AAS52362.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS52362.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS52362.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000256|RuleBase:RU003814}.
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DR   EMBL; AE016818; AAS52362.1; -; Genomic_DNA.
DR   RefSeq; NP_984538.1; NM_209891.1.
DR   STRING; 33169.AAS52362; -.
DR   EnsemblFungi; AAS52362; AAS52362; AGOS_AEL322W.
DR   GeneID; 4620708; -.
DR   KEGG; ago:AGOS_AEL322W; -.
DR   HOGENOM; HOG000176924; -.
DR   InParanoid; Q758S4; -.
DR   KO; K03680; -.
DR   OMA; CEKIAQF; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IEA:EnsemblFungi.
DR   GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IEA:EnsemblFungi.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:EnsemblFungi.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:EnsemblFungi.
DR   GO; GO:0006446; P:regulation of translational initiation; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.10470; -; 2.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q758S4.
DR   SWISS-2DPAGE; Q758S4.
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   REGION          1..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..59
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..91
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   604 AA;  66402 MW;  14E707489FC521AF CRC64;
     MSTDADVAST QRENAADANP RESSAEREAT APSVSEEHKL SNKELKELKK QEKAAKRAAK
     KQASGITIEQ QQQQAQLKKE KKQHQREQQM SGAKKGRSGN PGIPIADKKS TLFGHLETTE
     ERRASLLAVI SAISSNGASK ITATGLMIPT VASAMASSAA PALAAGHTGA AGPANPEVSA
     QAMASMSLDE ESSFVPGLLS VLPIAIEEDF KNPQLMSSVK ELVANKDMLH PAVVLLTSEF
     GAYKIVGSIP RCLAMLEVFQ IVIREYKTPE GTTLSRNLTH YLSHQIDFLK KARPLSVTMG
     NAIRWLKQEI SLIDPATSDV QAKELLCEKI AQFAREKVEL ADQLILENAS QHIDNDSTIL
     TYGCSKVLTD LFIYNAVDLG KNFNIIIVDS RPLFEGRKMA EVLRKRGLNI TYVMITSLAT
     IFSMDIDYVF LGAHSILSNG FLYSRVGTAM LAMSAKRRNI PVIVACESLK FSQRVQLDSV
     TFNELADPNI LVDINTDNPV KRRSNKGFLL QRFVKESQAL MKQKDEQDTK QNKNGKAKFI
     TDDNKKSDSD KAILADWQDL PSLNIYNIMY DLTPPEYIKK VVTEFGALPP SSVPVILREY
     KGSA
//

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