(data stored in SCRATCH zone)

SWISSPROT: Q75BM7_ASHGO

ID   Q75BM7_ASHGO            Unreviewed;       300 AA.
AC   Q75BM7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 89.
DE   RecName: Full=Transcription initiation factor IIE subunit beta {ECO:0000256|PIRNR:PIRNR016398};
GN   ORFNames=AGOS_ACR244C {ECO:0000313|EMBL:AAS51470.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51470.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51470.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Recruits TFIIH to the initiation complex and stimulates the
CC       RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase
CC       activities of TFIIH. Both TFIIH and TFIIE are required for promoter
CC       clearance by RNA polymerase. {ECO:0000256|PIRNR:PIRNR016398}.
CC   -!- SUBUNIT: Tetramer of two alpha and two beta chains.
CC       {ECO:0000256|PIRNR:PIRNR016398}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR016398}.
CC   -!- SIMILARITY: Belongs to the TFIIE beta subunit family.
CC       {ECO:0000256|PIRNR:PIRNR016398}.
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DR   EMBL; AE016816; AAS51470.1; -; Genomic_DNA.
DR   RefSeq; NP_983646.1; NM_208999.1.
DR   STRING; 33169.AAS51470; -.
DR   EnsemblFungi; AAS51470; AAS51470; AGOS_ACR244C.
DR   GeneID; 4619780; -.
DR   KEGG; ago:AGOS_ACR244C; -.
DR   HOGENOM; HOG000216656; -.
DR   InParanoid; Q75BM7; -.
DR   KO; K03137; -.
DR   OMA; FAFRPPH; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005673; C:transcription factor TFIIE complex; IBA:GO_Central.
DR   GO; GO:0097550; C:transcriptional preinitiation complex; IEA:EnsemblFungi.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; IEA:EnsemblFungi.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0001097; F:TFIIH-class transcription factor complex binding; IEA:EnsemblFungi.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   CDD; cd07977; TFIIE_beta_winged_helix; 1.
DR   InterPro; IPR040501; TFA2_Winged_2.
DR   InterPro; IPR016656; TFIIE-bsu.
DR   InterPro; IPR003166; TFIIE_bsu_DNA-bd.
DR   PANTHER; PTHR12716; PTHR12716; 1.
DR   Pfam; PF18121; TFA2_Winged_2; 1.
DR   Pfam; PF02186; TFIIE_beta; 1.
DR   PIRSF; PIRSF016398; TFIIE-beta; 1.
DR   PROSITE; PS51351; TFIIE_BETA_C; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q75BM7.
DR   SWISS-2DPAGE; Q75BM7.
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR016398};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR016398};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Transcription {ECO:0000256|PIRNR:PIRNR016398};
KW   Transcription regulation {ECO:0000256|PIRNR:PIRNR016398}.
FT   DOMAIN          85..158
FT                   /note="TFIIE beta"
FT                   /evidence="ECO:0000259|PROSITE:PS51351"
FT   REGION          27..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..92
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   300 AA;  33509 MW;  CB5456A95B6CCA73 CRC64;
     MSNDLLANLN AFKSKIKTAP VITTRRKVVA HQDSGSHSGG ARQSKAMKRE TPRDGGDQGA
     GQPSAAKKMK LGTASPQKAA VPSRSENGAL DSTHLSTKML IATEYIQERA EPVPIDQIES
     YLSLPKDNSV IPMLKGLAKF KFDPKKNTLQ YVSIYDVHSA EELLKLTRTQ VTFKGISCKE
     LKDGWPQCFE VIDELEKKNR ILVSRTKKDN SPRFVWYNFG GPLGEIDEDF VKMWENCKLP
     QRSELPRKLQ DLGLKPASVD PATIKKQGST RVEAKKRKQR KGKITNTHMA GILKDYSDRV
//

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