(data stored in SCRATCH zone)

SWISSPROT: Q75BQ8_ASHGO

ID   Q75BQ8_ASHGO            Unreviewed;       714 AA.
AC   Q75BQ8;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 91.
DE   RecName: Full=alpha-1,2-Mannosidase {ECO:0000256|RuleBase:RU361193};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361193};
GN   ORFNames=AGOS_ACR213W {ECO:0000313|EMBL:AAS51439.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51439.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51439.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 47 family.
CC       {ECO:0000256|RuleBase:RU361193}.
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DR   EMBL; AE016816; AAS51439.1; -; Genomic_DNA.
DR   RefSeq; NP_983615.1; NM_208968.1.
DR   STRING; 33169.AAS51439; -.
DR   CAZy; GH47; Glycoside Hydrolase Family 47.
DR   EnsemblFungi; AAS51439; AAS51439; AGOS_ACR213W.
DR   GeneID; 4619747; -.
DR   KEGG; ago:AGOS_ACR213W; -.
DR   InParanoid; Q75BQ8; -.
DR   KO; K01230; -.
DR   OMA; NSYAENE; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IBA:GO_Central.
DR   GO; GO:0006491; P:N-glycan processing; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR001382; Glyco_hydro_47.
DR   InterPro; IPR036026; Seven-hairpin_glycosidases.
DR   Pfam; PF01532; Glyco_hydro_47; 1.
DR   PRINTS; PR00747; GLYHDRLASE47.
DR   SUPFAM; SSF48225; SSF48225; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q75BQ8.
DR   SWISS-2DPAGE; Q75BQ8.
KW   Glycosidase {ECO:0000256|RuleBase:RU361193};
KW   Hydrolase {ECO:0000256|RuleBase:RU361193};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   714 AA;  79569 MW;  7347E5CB64470568 CRC64;
     MAGALVALAR RTRSVLVFAT TALILFYYTV ENQIDMLNSY AQTEHLPQIS KASGDSAPTP
     PDDLADPVQL VAKNRYFPLL LDTWRDAPQV HDTAEVRRRA PRYDTLHAKV EIRERPARGM
     RGRVQAPVHL LEADDDRLRA IRDAFMQDWQ QYKRLAWGHD GMQPLSAQPY DTTGLATTMI
     LSLEMLYLVG ATDDAEAVLQ FLGGFEFHAD KMPADWNATS DPTLGALIGA YELSHEPVLL
     SKAVELADII LEAFNTPSGA AMAPLDVRSP LQNRHPYRRS ALAHLAGVSV EFARLTQLTR
     DQKYFNSIYG LYDLAANSED EFDLEGLVTD YVDPSGCEIT TSEIRGIKSI FQGRYIGCKL
     VRRLRPAVGA RGSSDAEGIQ YYSWDGLAAW CRSLQDLALI VTDPELSAAF KNTLKAALEA
     IMNNMIFRPA LPESAAASEP DEPLFVSAVR TWSYTDASTG TDVVKVMREF DMTDASCALS
     GVLALAGAAL FVDDSKYKST ANGIMEGCAR LQQLLGTPVE RVYVDPCDAA DCYFDADKKS
     QLLSEGYYRK QGDHNDLLDG VKLTKSGAAR ITGAKKYIFV DTERSYDRDL ESWDPARPLF
     VNDWELLQSP EGHMIESLFY MFRLSGDSKL RLRAWEHWEA LVKLHTAVGA KGVAERKPSA
     FRNILAGERE DILPPEWFSK SLKYLYLMFS DGLKVGNLDD WVITAKGNMF RKTI
//

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