(data stored in SCRATCH zone)

SWISSPROT: Q75BU0_ASHGO

ID   Q75BU0_ASHGO            Unreviewed;       473 AA.
AC   Q75BU0;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 100.
DE   RecName: Full=V-type proton ATPase subunit H {ECO:0000256|PIRNR:PIRNR032184};
GN   ORFNames=AGOS_ACR181C {ECO:0000313|EMBL:AAS51407.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51407.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51407.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Subunit of the peripheral V1 complex of vacuolar ATPase.
CC       Subunit H activates ATPase activity of the enzyme and couples ATPase
CC       activity to proton flow. Vacuolar ATPase is responsible for acidifying
CC       a variety of intracellular compartments in eukaryotic cells, thus
CC       providing most of the energy required for transport processes in the
CC       vacuolar system. {ECO:0000256|PIRNR:PIRNR032184}.
CC   -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral
CC       catalytic V1 complex (components A to H) attached to an integral
CC       membrane V0 proton pore complex. {ECO:0000256|PIRNR:PIRNR032184}.
CC   -!- SIMILARITY: Belongs to the V-ATPase H subunit family.
CC       {ECO:0000256|PIRNR:PIRNR032184}.
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DR   EMBL; AE016816; AAS51407.1; -; Genomic_DNA.
DR   RefSeq; NP_983583.1; NM_208936.1.
DR   STRING; 33169.AAS51407; -.
DR   EnsemblFungi; AAS51407; AAS51407; AGOS_ACR181C.
DR   GeneID; 4619715; -.
DR   KEGG; ago:AGOS_ACR181C; -.
DR   HOGENOM; HOG000066030; -.
DR   InParanoid; Q75BU0; -.
DR   KO; K02144; -.
DR   OMA; GIQLQYY; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.40.150; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR004908; ATPase_V1-cplx_hsu.
DR   InterPro; IPR011987; ATPase_V1-cplx_hsu_C.
DR   InterPro; IPR038497; ATPase_V1-cplx_hsu_C_sf.
DR   PANTHER; PTHR10698; PTHR10698; 1.
DR   Pfam; PF11698; V-ATPase_H_C; 1.
DR   Pfam; PF03224; V-ATPase_H_N; 1.
DR   PIRSF; PIRSF032184; ATPase_V1_H; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q75BU0.
DR   SWISS-2DPAGE; Q75BU0.
KW   Hydrogen ion transport {ECO:0000256|PIRNR:PIRNR032184};
KW   Ion transport {ECO:0000256|PIRNR:PIRNR032184};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Transport {ECO:0000256|PIRNR:PIRNR032184}.
FT   DOMAIN          350..472
FT                   /note="V-ATPase_H_C"
FT                   /evidence="ECO:0000259|Pfam:PF11698"
SQ   SEQUENCE   473 AA;  53548 MW;  F887F4BD674B2E72 CRC64;
     MAVAQGVQKI LLDSTHFNDI RNTISSRHVA WDALVRSAEL SEFDAGIAKK LESTLLKHAR
     GGALDLPLEQ GVQALVHLLA TSNNLDAKRA VLNLLSELFT SDKYVHEVLR YFKKGPELVR
     KLYESTLTDS AADDQFVLLS CFNVVSLLIQ EGLQSEELVE ALVSNPNYLR VLTNLERMEL
     AYVCIRLLQE LVAVKRYRRL VWKHSAKFVP VIFQIIDWAL DGRSSTRVVP TNSNNLGIQA
     QYYALLTLWL LSFEPQIAAD LSHTYLSELL KLFKLVKVTI KEKVTRLSIA ILLNCVAAQV
     KGRKATIKNL LLLGSGLPIL QQLSERKYSD DELREDLSQL HGILESEYHE LTSLDEYVAE
     LDSKLLVWSP PHTDNTFWSE NAHKFKEENW KLFKQLINVL KELSTSHDSS DNVALQVVLN
     DITHIVELQP ECVDILGKLN AKVIIMELLN HPNSKVKYEA LKTTQAFVAN TFK
//

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