(data stored in SCRATCH zone)

SWISSPROT: Q75C45_ASHGO

ID   Q75C45_ASHGO            Unreviewed;       990 AA.
AC   Q75C45;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 106.
DE   RecName: Full=26S proteasome regulatory subunit RPN1 {ECO:0000256|PIRNR:PIRNR015965};
GN   ORFNames=AGOS_ACR072C {ECO:0000313|EMBL:AAS51298.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51298.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51298.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Acts as a regulatory subunit of the 26 proteasome which is
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       {ECO:0000256|PIRNR:PIRNR015965}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S2 family.
CC       {ECO:0000256|PIRNR:PIRNR015965}.
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DR   EMBL; AE016816; AAS51298.1; -; Genomic_DNA.
DR   RefSeq; NP_983474.1; NM_208827.1.
DR   STRING; 33169.AAS51298; -.
DR   EnsemblFungi; AAS51298; AAS51298; AGOS_ACR072C.
DR   GeneID; 4619599; -.
DR   KEGG; ago:AGOS_ACR072C; -.
DR   HOGENOM; HOG000176022; -.
DR   InParanoid; Q75C45; -.
DR   KO; K03028; -.
DR   OMA; MVDICAY; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:1905754; C:ascospore-type prospore nucleus; IEA:EnsemblFungi.
DR   GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0031595; C:nuclear proteasome complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IBA:GO_Central.
DR   GO; GO:0034515; C:proteasome storage granule; IBA:GO_Central.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030674; F:protein binding, bridging; IEA:EnsemblFungi.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0042176; P:regulation of protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR016643; 26S_Psome_Rpn1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR   InterPro; IPR041433; RPN1_C.
DR   InterPro; IPR040892; RPN1_RPN2_N.
DR   PANTHER; PTHR10943:SF1; PTHR10943:SF1; 1.
DR   Pfam; PF01851; PC_rep; 2.
DR   Pfam; PF18051; RPN1_C; 1.
DR   Pfam; PF17781; RPN1_RPN2_N; 1.
DR   PIRSF; PIRSF015965; 26S_Psome_Rpn1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q75C45.
DR   SWISS-2DPAGE; Q75C45.
KW   Proteasome {ECO:0000256|PIRNR:PIRNR015965};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   DOMAIN          49..357
FT                   /note="RPN1_RPN2_N"
FT                   /evidence="ECO:0000259|Pfam:PF17781"
FT   DOMAIN          933..986
FT                   /note="RPN1_C"
FT                   /evidence="ECO:0000259|Pfam:PF18051"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          624..658
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..727
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..25
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..41
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        626..648
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        687..727
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   990 AA;  109290 MW;  53EED27E0D1C8370 CRC64;
     MVDDIRNNED KQIGSASGLQ TPSAKKGKTK DQKQEEELSE DDLRLKADLE TLVQRLLESD
     ASLCEQSLAQ LKEFIKNSTS SMTAVPAPLK FLRPSYPDLC AVYDKWVDPK LKSLLADVLS
     VLSMTYSDEG KHDSLRFRLL SNEKDIESWG HEYIRHLALE VGDVYNEQVE NESDETYDQE
     SKRAISDAEF PKDVLVQLAL DIVPYFLKHN GEADAVDLLL EVESIDKLPQ FIDENTFQRV
     CQYMVSCVPL LPPPEDVTFL QTAFSLYLSE NQLTEALALA IRLGEESLIR SVFDATTDPV
     MHKQLAYILA AQKSSFEYSA VQDIIGSTKL SEHFLYLAKE LNLTVPKFPE DIYKSHLDNS
     VRSAFASSGL DSAQQNLAAS FVNGWLNLGY CADKMCLDDD NWVYKTKGDG MTSTVASIGS
     IYQWNLDGLQ HLDKYLYADD VEVKAGALLG IGVSACGVHD GDVEPALLLL QDYVTNPNAK
     LSSAAILGLG IAFAGSRNDE LLSLLLPIAA DTSLSIETSA MASLALAHAF VGTCNGDITT
     SIMDNLLERS SIELKTEWTR FLTLALGILY MGQGDQVEDV LETISAIEHP ITSAIEVLVN
     VCAYTGTGDV LLIQDLLYRL TPKKEEEEED DDENEDGEND EDGDDAEGER DGSGQNIPED
     IDSLVQEVMN TASTTEDSAI SNEESTSTSK KADEDKMDVD NSKEEDAKNG DQGKHESKDD
     ESSEKSMAHI DELTYSVLGI AMVAMGEDIG KEMSLRHFGH LMHYGNQHIR RVVPLAMGLV
     SVSDPQMKVF DTLSRFSHDP DLDVSINSIF AMGLCGCGTN NARLAQLLRQ LASYYSKEQN
     TLFVTRLAQG LVHLGKGTMT LDVFNDAQVL NKVTLASLLT VLIGLTSPTF MLKHHQLFYY
     LNSGIRPKFI LTLNEEGEPI KVNVRVGQAV DTVGQAGKPK TITGWITQST PVLLNHGERA
     ELETNEYISY ASRIEGVVIL KKNPNYKEEE
//

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