(data stored in SCRATCH zone)

SWISSPROT: Q75C84_ASHGO

ID   Q75C84_ASHGO            Unreviewed;       680 AA.
AC   Q75C84;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 93.
DE   RecName: Full=Nucleolar complex-associated protein 3 {ECO:0000256|PIRNR:PIRNR028977};
GN   ORFNames=AGOS_ACR032C {ECO:0000313|EMBL:AAS51259.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51259.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51259.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for synthesis of 60S ribosomal subunits and the
CC       transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
CC       {ECO:0000256|PIRNR:PIRNR028977}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|PIRNR:PIRNR028977}.
CC   -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC       {ECO:0000256|PIRNR:PIRNR028977}.
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DR   EMBL; AE016816; AAS51259.1; -; Genomic_DNA.
DR   RefSeq; NP_983435.1; NM_208788.1.
DR   STRING; 33169.AAS51259; -.
DR   EnsemblFungi; AAS51259; AAS51259; AGOS_ACR032C.
DR   GeneID; 4619560; -.
DR   KEGG; ago:AGOS_ACR032C; -.
DR   HOGENOM; HOG000168453; -.
DR   InParanoid; Q75C84; -.
DR   KO; K14834; -.
DR   OMA; LWNTEER; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0030691; C:Noc2p-Noc3p complex; IEA:EnsemblFungi.
DR   GO; GO:0005656; C:nuclear pre-replicative complex; IEA:EnsemblFungi.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0006267; P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication; IEA:EnsemblFungi.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IEA:EnsemblFungi.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR005612; CCAAT-binding_factor.
DR   InterPro; IPR011501; Noc3_N.
DR   InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR   PANTHER; PTHR14428; PTHR14428; 1.
DR   Pfam; PF03914; CBF; 1.
DR   Pfam; PF07540; NOC3p; 1.
DR   PIRSF; PIRSF028977; Nucleolar_complex_p3; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q75C84.
DR   SWISS-2DPAGE; Q75C84.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591};
KW   Ribosome biogenesis {ECO:0000256|PIRNR:PIRNR028977}.
FT   DOMAIN          156..246
FT                   /note="NOC3p"
FT                   /evidence="ECO:0000259|Pfam:PF07540"
FT   DOMAIN          491..667
FT                   /note="CBF"
FT                   /evidence="ECO:0000259|Pfam:PF03914"
FT   REGION          19..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          111..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          384..425
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        19..44
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..150
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   680 AA;  77253 MW;  15C424D1A6C22C94 CRC64;
     MSYNHSECIL RLDSSRYDSK MANKKRSQKA IQERTDKKRK LQDAQLENGL FGADVNSIDI
     GEEMPAKIAS GKWEDNEQDY ELKPRRMQDS EHELVEGLPI KINGKLERKM RVVQRAPENN
     EVSEDDSEKS EDESKQEESA DEEDEEPDTE ERILEMKELI AELVEKIIEE PEENTSALTR
     LRKMAESKNP NTSKFSMLAL IPVWKSIIPG YRIRPLTEME KKEKVSKDVA RLRNFEEKLV
     HNYKLYIDHL ASLARTANNE PALKVRLGNI AATAAVELAG SFSHFNFMSE VLTIVVRRVC
     KPNPSADPVF SKAIKVLETL MNEDDEGRVS AEIVRLLSRT LKVRNYNVDE SVLNSLLSVD
     VLHDYDPNTK TDEPTKVKLK KKDRVHLSKK QRKVRKEMKE IEEEMRKAEQ AVSAEEREKN
     QAELLKLILA LYLNVLKANQ QKLIGSVLEG LAKFGHMANL ELLGDFLTVM KELISDADLN
     ALSSAEVRKV LLCIVTAFSL VSNHRHMKLS VDLSSFVDAL YSVLPYLSLD ADVEFSHKTL
     RLADPLNNEL VKPSVNVSTK AELLLKALDH VFFRSKSGTQ QRAAAFTKRL YICMEHTPEK
     TTVALLKFLD KLMTKYPQIA GLYSTNDRIG NGTFYMEAST PARSNPDAAT IWENALLTKH
     YCPLVVKGTK ALFNRSKEST
//

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