(data stored in SCRATCH zone)

SWISSPROT: Q75CM6_ASHGO

ID   Q75CM6_ASHGO            Unreviewed;       354 AA.
AC   Q75CM6;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 95.
DE   SubName: Full=ACL107Cp {ECO:0000313|EMBL:AAS51121.1};
GN   ORFNames=AGOS_ACL107C {ECO:0000313|EMBL:AAS51121.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51121.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51121.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
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DR   EMBL; AE016816; AAS51121.1; -; Genomic_DNA.
DR   RefSeq; NP_983297.1; NM_208650.1.
DR   STRING; 33169.AAS51121; -.
DR   EnsemblFungi; AAS51121; AAS51121; AGOS_ACL107C.
DR   GeneID; 4619417; -.
DR   KEGG; ago:AGOS_ACL107C; -.
DR   HOGENOM; HOG000250272; -.
DR   InParanoid; Q75CM6; -.
DR   KO; K17743; -.
DR   OMA; MTQINTL; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IBA:GO_Central.
DR   GO; GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0032866; F:D-xylose:NADP reductase activity; IEA:EnsemblFungi.
DR   GO; GO:0003729; F:mRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0019568; P:arabinose catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0071470; P:cellular response to osmotic stress; IEA:EnsemblFungi.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IEA:EnsemblFungi.
DR   GO; GO:0042843; P:D-xylose catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0019388; P:galactose catabolic process; IEA:EnsemblFungi.
DR   CDD; cd06660; Aldo_ket_red; 1.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR020471; Aldo/keto_reductase.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; PTHR11732; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   4: Predicted;
DR   PRODOM; Q75CM6.
DR   SWISS-2DPAGE; Q75CM6.
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
FT   DOMAIN          45..333
FT                   /note="Aldo_ket_red"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        77
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         139
FT                   /note="Substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            106
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   354 AA;  39873 MW;  5C1808B5EB2A128E CRC64;
     MVYKQLYMRG TPPDLSRCIT GQDIAMVMNV RTIKLNNGAD MPLVGLGCWK IPNEVAAEQV
     YEAIKLGYRL LDGAEDYANE REVGQGIRRA IDEGLVRREE LFVVSKLWNN YHRPEDVGKA
     LQRTLSDLGL DYLDLFYIHF PLAFKFVPLE ERYPAGLYTG AADEQAGRLA QEPVPLIETY
     RALEQLVDEG RIRAIGLSNF QGCLVQDLLR GCRIRPAALQ IEHHPYLTQE RLVQYAKSEG
     LAVVGYSSLG PQSFLELGNT AAQNAAPLLQ HEVVCRIAER HTATPAEVLL RWATQRDIAV
     IPKSSRKERL ATNLRVDEAL TLADDELREL SSLNCGLRFN DPWDWSAQPL PTFI
//

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