(data stored in SCRATCH zone)

SWISSPROT: Q75CT7_ASHGO

ID   Q75CT7_ASHGO            Unreviewed;       126 AA.
AC   Q75CT7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   11-DEC-2019, entry version 97.
DE   RecName: Full=Profilin {ECO:0000256|RuleBase:RU003909};
GN   ORFNames=AGOS_ACL168C {ECO:0000313|EMBL:AAS51060.1};
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811 {ECO:0000313|EMBL:AAS51060.1, ECO:0000313|Proteomes:UP000000591};
RN   [1] {ECO:0000313|EMBL:AAS51060.1, ECO:0000313|Proteomes:UP000000591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2] {ECO:0000313|Proteomes:UP000000591}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056
RC   {ECO:0000313|Proteomes:UP000000591};
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations.
CC       {ECO:0000256|RuleBase:RU003908}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio. {ECO:0000256|RuleBase:RU003908}.
CC   -!- SIMILARITY: Belongs to the profilin family.
CC       {ECO:0000256|RuleBase:RU003909, ECO:0000256|SAAS:SAAS00570314}.
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DR   EMBL; AE016816; AAS51060.1; -; Genomic_DNA.
DR   RefSeq; NP_983236.1; NM_208589.1.
DR   STRING; 33169.AAS51060; -.
DR   EnsemblFungi; AAS51060; AAS51060; AGOS_ACL168C.
DR   GeneID; 4619356; -.
DR   KEGG; ago:AGOS_ACL168C; -.
DR   HOGENOM; HOG000171591; -.
DR   InParanoid; Q75CT7; -.
DR   KO; K05759; -.
DR   OMA; NDRSIYG; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0051285; C:cell cortex of cell tip; IEA:EnsemblFungi.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0043332; C:mating projection tip; IEA:EnsemblFungi.
DR   GO; GO:0031097; C:medial cortex; IEA:EnsemblFungi.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR   GO; GO:0044396; P:actin cortical patch organization; IEA:EnsemblFungi.
DR   GO; GO:1904670; P:actin filament polymerization involved in mitotic actomyosin contractile ring assembly; IEA:EnsemblFungi.
DR   GO; GO:0000755; P:cytogamy; IEA:EnsemblFungi.
DR   GO; GO:1904530; P:negative regulation of actin filament binding; IEA:EnsemblFungi.
DR   GO; GO:2000812; P:regulation of barbed-end actin filament capping; IEA:EnsemblFungi.
DR   GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q75CT7.
DR   SWISS-2DPAGE; Q75CT7.
KW   Actin-binding {ECO:0000256|RuleBase:RU003909,
KW   ECO:0000256|SAAS:SAAS00682009}; Cytoplasm {ECO:0000256|RuleBase:RU003908};
KW   Cytoskeleton {ECO:0000256|RuleBase:RU003908};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000591}.
SQ   SEQUENCE   126 AA;  13668 MW;  2C7827930BB8D5E0 CRC64;
     MSWQAYTDNL LATGKVDKAT IYSRAGDTIW ASSGGLALEP SEIKEISQGF DNAAGLQANG
     LHIQGQKFML LRADERSIYG RHEAEGVVAV RTKQTILIAH YPAGVQAGEA TKIVEQLADY
     LISVQY
//

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