(data stored in SCRATCH zone)

SWISSPROT: Q79ZT2_STRAW

ID   Q79ZT2_STRAW            Unreviewed;      3352 AA.
AC   Q79ZT2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   08-MAY-2019, entry version 51.
DE   SubName: Full=Modular polyketide synthase {ECO:0000313|EMBL:BAC68125.1};
GN   Name=pteA5 {ECO:0000313|EMBL:BAC68125.1};
GN   ORFNames=SAVERM_415 {ECO:0000313|EMBL:BAC68125.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 /
OS   NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC68125.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC68125.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C.,
RA   Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T.,
RA   Kikuchi H., Shiba T., Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces
RT   avermitilis: deducing the ability of producing secondary
RT   metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC68125.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; BA000030; BAC68125.1; -; Genomic_DNA.
DR   RefSeq; WP_010981852.1; NZ_BAVY01000044.1.
DR   STRING; 227882.SAV_415; -.
DR   EnsemblBacteria; BAC68125; BAC68125; SAVERM_415.
DR   KEGG; sma:SAVERM_415; -.
DR   eggNOG; COG3321; LUCA.
DR   OMA; YAFAHER; -.
DR   OrthoDB; 1123553at2; -.
DR   BioCyc; SAVE227882:G1G23-465-MONOMER; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.1200.10; -; 2.
DR   Gene3D; 3.40.366.10; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR032821; KAsynt_C_assoc.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR041618; PKS_DE.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR036299; Polyketide_synth_docking_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF00698; Acyl_transf_1; 2.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF18369; PKS_DE; 2.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00827; PKS_AT; 2.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF101173; SSF101173; 1.
DR   SUPFAM; SSF47336; SSF47336; 2.
DR   SUPFAM; SSF51735; SSF51735; 4.
DR   SUPFAM; SSF52151; SSF52151; 2.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   SUPFAM; SSF55048; SSF55048; 2.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
DR   PRODOM; Q79ZT2.
DR   SWISS-2DPAGE; Q79ZT2.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000428};
KW   Phosphopantetheine {ECO:0000256|PROSITE-ProRule:PRU00258};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428}.
FT   DOMAIN     1433   1508       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     2978   3053       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   COILED       12     32       {ECO:0000256|SAM:Coils}.
FT   MOD_RES    1468   1468       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
FT   MOD_RES    3013   3013       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   3352 AA;  353401 MW;  66A5865BFD2027B7 CRC64;
     MSSKEDRLLE YLKRVTGDLR QVRERLREVE EKDDDPIAIV GMACRYPGGV RSPEDLWHLV
     AAGGDAVGDF PADRGWDVEG IYDPDPDARG KTYARRGGFL YEAGEFDPGF FGISPREAVA
     MDPQQRLLLE TTWETFERAG IDAESVRGSR TGVFVGSGYQ DYVNLLVGVG GESDGHLGTG
     NSASVMSGRI AYTFGLEGPA VTVDTACSSS LVALHWAIQA LRNGECSMAL AGGVQVMTTP
     TAFVEFSRQR GLAPDGRCKA FGAGADGTGW AEGVGMLLVE RLSDAVRNGH EVLAVVRGSA
     VNQDGASNGL TAPNGPAQQR VIRQALASAG LSPAQIDVVE AHGTGTTLGD PIEAQALLAT
     YGRERTEDRP LWLGSLKSNI GHSQAAAGVG GIIKMVMAMR HGVLPQTLHV DEPTPHVDWS
     AGAVRLLTEA VEWPETHHPR RAAVSSFGVS GTNAHTIIEQ APPAQDEGPA GALVDGPLAW
     VLSARSDAAL RAQAARLRPS ARGEVRPQDI GLSLATTRAA MRHRAAVVGD NREELLSGLE
     DLATGTPSSR VLLGRPAGGK TGFLFSGQGS QRIGMGRELY AAYPVFAAAY DEVCAHLDAP
     VDVDAETLHR TGGTQPALFA VEVALFRLLE SLGVRPDFVV GHSVGEIAAA HVAGALSLDD
     AAKLVSARAA LMQALPAGGA MVAVQATEEE VLPHLTDGVS IAAVNGPSSV VVSGDETAAL
     AIAAGFAEQG RKTSRLKVSH AFHSPLMDPM LAEFAEVVRG LAFEQPQLPV VSNLTGQPVE
     AYTPEYWVRH VRETVRFADS VRTLHDLGVK TFIEIGPGGV LSGMAQGCAD DIVTVPVLRA
     DRPERQAVVT ALAHLHTHGV SVDWHSFFAG ARRTDLPTYA FQREWYWVDA PESAAAEADP
     VDAEFWETVE RGDLQALAET LDIGAGDTFG DVLPRLSSWR RQRKEQSTVD DRRYRESWKR
     LGELGPAGIG GTWLLAVPAE ENEQTAAVRT ALTARGATLK TLVVDAASHR AGLAGELAGI
     GPVDGVLSLL VNGDPVLPTL LLVQALGDAG VDAPLWCLTS GAVAVSGSDA VRDARHAQVW
     GLGRTVALEL PRRWGGLIDL PESVDDQAAV RLADVLEQAL TGRWEEDQLA VRASGVFARR
     LAHAPARAAT RRWQPRGTVL ITGGTGALGG HVARWLARGG AEHLVLTSRR GADAPGAAAL
     RDELEVLGAR VTFAACDVAD RDAVAALLAQ HVFTAVVHAA GVADAGTVDA TTPAAFAAAL
     AAKVGGAAHL DELLGDQELD AFVLFSSISG VWGSGGQAAY AAGNAFLDGL ARQRRDRGLT
     ATAVSWGPWA DGGMVADGDD EERLRRRGLR AMTPASAITS LQRALDRDET LLTVADVDWS
     RFIVPFTLGR PSPLLGDLPE VRAALAVDTP AAGHGSGALA ESLAALSHQD RARALVDLVR
     THAAAVLGHR GAGAVEADRP FRDIGFDSLT AVELRNRINK ATGLSLPATL IFDHPTAADL
     AAHLLAELTG GQHEAVAAAA TAAVLDEPIA IIGMACRYPG GVRSPEDLWE LVASGRDAIS
     RFPGNRGWDV EALYHPDPDH PGTTYTTQGG FLHDADEFDP AVFGISPREA VAMDPQQRLL
     LDTTWEAFER ARIAPHAMRS TTTGVFVGSG YQDYTGRPLK VPDGVEGYIP SGNAASVISG
     RLSYTFGLQG PSVTVDTACS SSLTALHLAM QALRGGECSM ALAGGVMVMA GPSAFTMSSR
     QRALSADGRC KAFSSSADGT GFAEGVGLVL LERLSDARRN GHEVLAVVRG SAVNQDGASN
     GLTAPSGKAQ QQVIRQALAN ARLAPDEVDA VEAHGTGTRL GDPIEAQALL ATYGKERSEG
     RPLWLGSLKS NIGHTQAAAG VGGVIKMVMA IRNGILPQTL HVDEPTPHVD WAGGNVRLLT
     EQTAWPDQDR PRRAAVSSFG MSGTNVHTII EQAPQTATAA EVEQPPAAQD ATAAQPLDVF
     PWALSAKTDR SLREQARRLL NHLDRTEGLT LPDVGRALVT TRTQLEQRAV VVGQDRHELR
     AGLAALADGK PADTVVQGTA SASGKVAFVF PGHGSQWTEM ARELLDTSPV FAEQAKACAE
     AFAPYLDWPL LDVLRAEPDA PDVADVEVAQ PALFTVMVSL AALWRSYGVT PAAVVGHSQG
     EVAAAYVAGA LTLDDAARIV ALRSRSLTKL IGKGAMLAIA MPAERVRARL EKYGDRLSVA
     AVNGPAALTV SGEPDAVDEL LAELEAEGVR VRKVRGATGA GHSTQVESLR PELLHLLAPV
     APGAAEVPYY STVTGTVLDT TTLDAEYWYR NARHTVEFEW TVRTLLADGH GVFVECSPHP
     LLADAVQEIA EETGADAVTG SSLRRGQGGM DRFLRSVSEL HVSGVHVDLT APFAGRPVRR
     VDLPTYAFQP QRYWLESADP VPAGTDPVEA GFWELVENTD LSGLADELGA DDAALVGPAL
     PVLSAWRRRS REKSTVDGWR YRVSFRRLTD HAAPGLNGLW LAVLPAGLAD EQWAPCVVGV
     LAAHGAKVRV VELPVDCDRS QAAKRLAEEL RGEQPAGVLS MLGLAPGCHP AHPTLSASLA
     TTVTLLQALG DVDVQAPLWC ATRGAVSTGV TDPLRDAGQA QLWGLGVVAA LELPRRWGGL
     VDLPEELDEH ALRRLAGVLA QHDEDQLAVR VDGVYGRRMV RARPADEESA TPWKPRGTVL
     ITGGTGGVGR HLARWLAGAG AQHLVLTSRS GPDAPGAQEL HAELTALGAE VTIAACDMAD
     RAAVARLLAG IESRHPLTAV LHAAGTARSS MLADAGLDEF AEAAASKVTG AIHLDELLDG
     RELDAFVLFA SGAGVWGSGG QASYASANAF LDALALRRRA RGLTATSVAW GGWAGGGMVD
     DAVQERGERR GLGVMAPELA ISALREAVEH DEAALTVAPI DWEKFLPAFT VGRPSPLLAD
     LPDVQRLLEA EQAVGEGTSA GAALATELAA LAPVEQEERL LEHVRAQSAV VLGHASAEDV
     LPTAHFLELG FDSLTAIDLR RRLSAATGLR LPSGLAFDHP TPARLAKHLL TRLQSTGSAA
     AEERPADMLV QLYRHASENG TAAEAMGMLM EAARFRPSFE RPEELDRRPA PVRLSQGDHP
     LALMCFSPYV VPAGAHQYAR FAAPFRDRLD VWALVHPGYE KGEPVPSDPD VVFRLHAQTV
     RECAGGKPAV LLGYSSGGWI AHGVAAHLEA MGERPAAVVM VDSFSREVPF DHQVLNAMAQ
     AHSQRLDFMR SGGEQLTAMG RYMRLFDDWA APQIAAPTLL VRASEPMLAG AGDGDGRAAP
     PEHVDTIVEV TGNHYSMLED HAGTTAAAVD SWLADAVTDA SGPVAPADAT TA
//

If you have problems or comments...

PBIL Back to PBIL home page