(data stored in SCRATCH zone)

SWISSPROT: Q7AKI1_STRCO

ID   Q7AKI1_STRCO            Unreviewed;       307 AA.
AC   Q7AKI1;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   11-DEC-2019, entry version 42.
DE   SubName: Full=Hydroxylacyl-CoA dehydrogenase {ECO:0000313|EMBL:CAC37460.1};
DE   SubName: Full=Ketoreductase RED1 {ECO:0000313|EMBL:TYP12644.1};
GN   OrderedLocusNames=SCO5072 {ECO:0000313|EMBL:CAC37460.1};
GN   ORFNames=FHV98_108230 {ECO:0000313|EMBL:TYP12644.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226 {ECO:0000313|Proteomes:UP000001973};
RN   [1] {ECO:0000313|EMBL:CAC37460.1, ECO:0000313|Proteomes:UP000001973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A3 {ECO:0000313|EMBL:CAC37460.1}, and ATCC BAA-471 / A3(2) /
RC   M145 {ECO:0000313|Proteomes:UP000001973};
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA   Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2] {ECO:0000313|EMBL:TYP12644.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ICSSB 1010 {ECO:0000313|EMBL:TYP12644.1};
RA   Yuzawa S.;
RT   "Genome sequencing of Streptomyces strains engineered using actinophage
RT   integration system.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AL939122; CAC37460.1; -; Genomic_DNA.
DR   EMBL; VNID01000008; TYP12644.1; -; Genomic_DNA.
DR   RefSeq; NP_629223.1; NC_003888.3.
DR   RefSeq; WP_011030038.1; NC_003888.3.
DR   STRING; 100226.SCO5072; -.
DR   EnsemblBacteria; CAC37460; CAC37460; CAC37460.
DR   GeneID; 1100513; -.
DR   KEGG; sco:SCO5072; -.
DR   PATRIC; fig|100226.15.peg.5151; -.
DR   eggNOG; COG1250; LUCA.
DR   InParanoid; Q7AKI1; -.
DR   KO; K05556; -.
DR   OMA; WRDRRLM; -.
DR   PhylomeDB; Q7AKI1; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   4: Predicted;
DR   PRODOM; Q7AKI1.
DR   SWISS-2DPAGE; Q7AKI1.
KW   Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT   DOMAIN          3..171
FT                   /note="3HCDH_N"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          176..264
FT                   /note="3HCDH"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   SITE            129
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ   SEQUENCE   307 AA;  33261 MW;  1447860FBE3FE39D CRC64;
     MSTVTVIGAG TIGLGWINLF SARGLTVRVN SRRPDVRRVV HEALELFSPG RVDELAARIE
     YEPDVGRAVA GADVVSENAP DDLPLKQRLF AEIGAAAPDH ALVLSSTSKL LPDELSRDMP
     GPGRLVVAHP FNPPHIVPLV EVVRGERTDP EAVERTLAFL ASVGRTPVVV RRALPGFAAN
     RLQSALLRES IHLVLEGVVT VEELDRIVTD SIGLRWSTIG PFHAFHLGGG PGGLRKWLEH
     LGSGLEQGWR GLGQPALTPQ AVEALVAQTE AAYGHRPYAE LVRDRDDRHL AVLAALERTE
     QPQEETK
//

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