(data stored in SCRATCH zone)

SWISSPROT: Q7K6B1_PLAF7

ID   Q7K6B1_PLAF7            Unreviewed;       185 AA.
AC   Q7K6B1;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 2.
DT   11-DEC-2019, entry version 97.
DE   SubName: Full=Histidine triad nucleotide-binding protein 1 {ECO:0000313|EMBL:CAD51199.2};
GN   ORFNames=PF3D7_0817500 {ECO:0000313|EMBL:CAD51199.2};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51199.2, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00464}.
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DR   EMBL; AL844507; CAD51199.2; -; Genomic_DNA.
DR   RefSeq; XP_001349350.2; XM_001349314.2.
DR   SMR; Q7K6B1; -.
DR   IntAct; Q7K6B1; 2.
DR   PRIDE; Q7K6B1; -.
DR   EnsemblProtists; CAD51199; CAD51199; PF3D7_0817500.
DR   GeneDB; PF3D7_0817500.1:pep; -.
DR   GeneID; 2655259; -.
DR   KEGG; pfa:PF3D7_0817500; -.
DR   EuPathDB; PlasmoDB:PF3D7_0817500; -.
DR   HOGENOM; HOG000061064; -.
DR   InParanoid; Q7K6B1; -.
DR   OMA; VNDGKMG; -.
DR   PhylomeDB; Q7K6B1; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008426; F:protein kinase C inhibitor activity; ISS:GeneDB.
DR   Gene3D; 3.30.428.10; -; 1.
DR   InterPro; IPR019808; Histidine_triad_CS.
DR   InterPro; IPR001310; Histidine_triad_HIT.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   Pfam; PF01230; HIT; 1.
DR   PRINTS; PR00332; HISTRIAD.
DR   SUPFAM; SSF54197; SSF54197; 1.
DR   PROSITE; PS00892; HIT_1; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
DR   PRODOM; Q7K6B1.
DR   SWISS-2DPAGE; Q7K6B1.
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          76..185
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
SQ   SEQUENCE   185 AA;  21177 MW;  BC8566B9EF49AB62 CRC64;
     MGFKIVFIYL IFVCLMKIIP GFFTNKLTNS FYSTFVKLSY KNKFMTGILT RRLAKMADEE
     ERALEAAGKD ENGDSIFGKI ARGEVPVDAV YEDDKVIAFN DIYPQAPVHI IVIPKRRDGL
     TRLSKAEEKH KEILGHLMWA VAEIVRKNNL GDFRLVVNNG PEACQSIYYL HLHILAKRQM
     KWPPG
//

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