(data stored in ACNUC1829 zone)

SWISSPROT: Q7PTA7_ANOGA

ID   Q7PTA7_ANOGA            Unreviewed;       229 AA.
AC   Q7PTA7;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 3.
DT   08-MAY-2019, entry version 111.
DE   RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
GN   Name=1269922 {ECO:0000313|VectorBase:AGAP007209-PA,
GN   ECO:0000313|VectorBase:AGAP007209-PC,
GN   ECO:0000313|VectorBase:AGAP007209-PE};
GN   ORFNames=AgaP_AGAP007209 {ECO:0000313|EMBL:EAA04202.4};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA04202.4, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|EMBL:EAA04202.4, ECO:0000313|Proteomes:UP000007062, ECO:0000313|VectorBase:AGAP007209-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA04202.4,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H.,
RA   Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2] {ECO:0000313|EMBL:EAA04202.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA04202.4};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:EAA04202.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA04202.4};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [4] {ECO:0000313|EMBL:EAA04202.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA04202.4};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [5] {ECO:0000313|EMBL:EAA04202.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA04202.4};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|VectorBase:AGAP007209-PA, ECO:0000313|VectorBase:AGAP007209-PC, ECO:0000313|VectorBase:AGAP007209-PE}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP007209-PA,
RC   ECO:0000313|VectorBase:AGAP007209-PC};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361218};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361218}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|RuleBase:RU361218, ECO:0000256|SAAS:SAAS01169470}.
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DR   EMBL; AAAB01008807; EAA04202.4; -; Genomic_DNA.
DR   EMBL; AAAB01008807; EDO64655.1; -; Genomic_DNA.
DR   EMBL; AAAB01008807; EDO64656.1; -; Genomic_DNA.
DR   RefSeq; XP_001688006.1; XM_001687954.1.
DR   RefSeq; XP_001688007.1; XM_001687955.1.
DR   RefSeq; XP_308576.3; XM_308576.4.
DR   STRING; 7165.AGAP007209-PA; -.
DR   EnsemblMetazoa; AGAP007209-RA; AGAP007209-PA; AGAP007209.
DR   EnsemblMetazoa; AGAP007209-RC; AGAP007209-PC; AGAP007209.
DR   EnsemblMetazoa; AGAP007209-RE; AGAP007209-PE; AGAP007209.
DR   GeneID; 1269922; -.
DR   VectorBase; AGAP007209-RA; AGAP007209-PA; AGAP007209.
DR   VectorBase; AGAP007209-RC; AGAP007209-PC; AGAP007209.
DR   VectorBase; AGAP007209-RE; AGAP007209-PE; AGAP007209.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   HOGENOM; HOG000230651; -.
DR   OMA; AWDNRTR; -.
DR   OrthoDB; 1406905at2759; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q7PTA7.
DR   SWISS-2DPAGE; Q7PTA7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Membrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00429796};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Transmembrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00028015};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00429788}.
FT   TRANSMEM     12     36       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM     56     77       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM     89    109       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM    194    220       Helical. {ECO:0000256|RuleBase:RU361218}.
SQ   SEQUENCE   229 AA;  24645 MW;  AC3E5BBEA721A66B CRC64;
     MALNCGHSTI KYLLFIFNLL CSLCGIALIV IGAVSLVKLE ELREISDEYN IVAPSILLIV
     FGSVVFVISF FGCCGAIRES YCMTSTYSFF LILLVIAQIV IAVLVFVFVG DVTTAIKKGF
     ERVFENRDNP VNADLVNSIQ QNLQCCGKRS FLDYGVASFP QSCCSSGGTA PLCVPFASGC
     LSRLSEFLDS AGNIVAWVSL GVAAVELVGL ISACCLANAI RNQQRRSGY
//

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