(data stored in ACNUC11299 zone)

SWISSPROT: Q7Q3C6_ANOGA

ID   Q7Q3C6_ANOGA            Unreviewed;      1878 AA.
AC   Q7Q3C6;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 3.
DT   30-AUG-2017, entry version 101.
DE   RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE            EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
DE   Flags: Fragment;
GN   ORFNames=AgaP_AGAP007810 {ECO:0000313|EMBL:EAA12308.3};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|EMBL:EAA12308.3, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA12308.3,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R.,
RA   Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J.,
RA   Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription
CC       of DNA into RNA using the four ribonucleoside triphosphates as
CC       substrates. {ECO:0000256|RuleBase:RU004279}.
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1). {ECO:0000256|RuleBase:RU004279}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC       {ECO:0000256|RuleBase:RU004279}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAA12308.3}.
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DR   EMBL; AAAB01008964; EAA12308.3; -; Genomic_DNA.
DR   RefSeq; XP_317690.3; XM_317690.3.
DR   STRING; 7165.AGAP007810-PA; -.
DR   PaxDb; Q7Q3C6; -.
DR   EnsemblMetazoa; AGAP007810-RA; AGAP007810-PA; AGAP007810.
DR   GeneID; 1278148; -.
DR   KEGG; aga:AgaP_AGAP007810; -.
DR   eggNOG; KOG0260; Eukaryota.
DR   eggNOG; COG0086; LUCA.
DR   HOGENOM; HOG000222975; -.
DR   InParanoid; Q7Q3C6; -.
DR   KO; K03006; -.
DR   OMA; MPDFDPT; -.
DR   OrthoDB; EOG091G00CH; -.
DR   PhylomeDB; Q7Q3C6; -.
DR   Proteomes; UP000007062; Chromosome 3R.
DR   GO; GO:0005665; C:DNA-directed RNA polymerase II, core complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006366; P:transcription from RNA polymerase II promoter; IEA:InterPro.
DR   InterPro; IPR000722; RNA_pol_asu.
DR   InterPro; IPR000684; RNA_pol_II_repeat_euk.
DR   InterPro; IPR006592; RNA_pol_N.
DR   InterPro; IPR007080; RNA_pol_Rpb1_1.
DR   InterPro; IPR007066; RNA_pol_Rpb1_3.
DR   InterPro; IPR007083; RNA_pol_Rpb1_4.
DR   InterPro; IPR007081; RNA_pol_Rpb1_5.
DR   InterPro; IPR007075; RNA_pol_Rpb1_6.
DR   InterPro; IPR007073; RNA_pol_Rpb1_7.
DR   Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR   Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR   Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR   Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR   Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR   Pfam; PF04992; RNA_pol_Rpb1_6; 1.
DR   Pfam; PF04990; RNA_pol_Rpb1_7; 1.
DR   SMART; SM00663; RPOLA_N; 1.
DR   PROSITE; PS00115; RNA_POL_II_REPEAT; 12.
PE   3: Inferred from homology;
DR   PRODOM; Q7Q3C6.
DR   SWISS-2DPAGE; Q7Q3C6.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   DNA-directed RNA polymerase {ECO:0000256|RuleBase:RU004279};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU004279};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Transcription {ECO:0000256|RuleBase:RU004279};
KW   Transferase {ECO:0000256|RuleBase:RU004279}.
FT   DOMAIN      236    539       RPOLA_N. {ECO:0000259|SMART:SM00663}.
FT   COILED      925    959       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:EAA12308.3}.
SQ   SEQUENCE   1878 AA;  207718 MW;  3A013743E47A46EA CRC64;
     RMSGESKAPL RLVKRVQFGI LSPDEIRRMS VTEGGIQYAE TMEGGRPKLC GLMDPRQGVI
     ERTSRCQTCA GNMTECPGHF GHIDLAKPVF HIGFITKTIK ILRCVCFYCS KMLVSPQNPK
     IKEIVLKSKG QPRKRLAYVY DLCKGKKICE GGEDMDMSKE PTADGAKKQG HGGCGHYQPS
     IRRTGLDLMA EWKDVNDENQ EKKIQVSAER VYEILKHITD EECFVLGMDP KFARPDWMII
     TVLPVPPLAV RPAVVMFGAT KNQDDLTHKL SDIIKANNEL KKNEATGAAA HVIAENIKML
     QFHVATLVDN DMPGMPKAMQ KSGKPLKAIK ARLKGKEGRI RGNLMGKRVD FSARTVITPD
     PNLRIDQVGV PRSVAQNMTF PELVTPFNID RMQELVRRGN SQYPGAKYIV RDNGERIDLR
     FHPKSSDLHL QCGYKVERHL RDDDLVIFNR QPTLHKMSMM GHRVKVLPWS TFRMNLSCTS
     PYNADFDGDE MNLHVPQSME TRAEIENIHI TPRQIITPQA NKPVMGIVQD TLTAVRKMTK
     RDVFIEKEQM MNLLMFLPTW DGKMPQPAIL KPKPLWTGKQ IFTLIIPGNV NMIRTHSTHP
     DEEDDGPYKW ISPGDTKVMV EHGDLIMGIL CKKTLGTSAG SLLHIVFLEL GHEIAGRFYG
     NIQTVVNNWL LLEGHSIGIG DTIADPQTYA EIQRAIKKAK EDVIGVIQKA HNMELEPTPG
     NTLRQTFENQ VNRILNDARD KTGGSAKKSL TEYNNLKAMV VSGSKGSNIN ISQVIACVGQ
     QNVEGKRIPF GFRKRTLPHF IKDDYGPESR GFVENSYLAG LTPTEFYFHA MGGREGLIDT
     AVKTAETGYI QRRLIKAMES VMVNYDGTVR NSVGQLIQLR YGEDGLCGET VEFQNLPTIK
     LSNKVFEKRY RFDPTNERTL RRIFNEDVIK ELTETSSVIQ EIEAEYEQLL RDREALRQIF
     PNGDSKVVLP CNLQRMIWNV QKIFHINKRS PTDLSPLKVI QGVRDLLQRC VIVAGTDRLS
     KQANENATLL FQCLVRSTLC TKYVAEEFRL NNEAFEWLIG EIETRFQQAQ CNPGEMVGAL
     AAQSLGEPAT QMTLNTFHFA GVSSKNVTLG VPRLKEIINI SKRPKAPSLT VFLTGGAARD
     AEKAKNVLCR LEHTTLRKVT ANTAIYYDPD PQRTVIAEDQ EFVNVYYEMP DFDPTRISPW
     LLRIELDRKR MTDKKLTMEQ IAEKINAGFG DDLNCIFNDD NADKLVLRIR IMNEDNKFQE
     NEEENMDKME DDMFLRCIEA NMLSDMTLQG IEAIGKVYMH LPQTDAKKRI VITPEGEFKP
     IGEWLLETDG TSMMKVLSER DVDPVRTYSN DICEIFSVLG IEAVRKSVEK EMNNVLQFYG
     LYVNYRHLAL LCDVMTAKGH LMAITRHGIN RQDTGALMRC SFEETVDVLN DAAAHAEVDP
     MRGVSENIIL GQLPRMGTGC FDLLLDAEKC KLGMEIPHTS ILGGTGMFFG SAATPSMTPW
     QQSATPGYGG WSPSGPASGM TPGGPSFSPS AQSDASGMSP SSWSPIRGSP SSPGPSMSPY
     PPSSPSMSPS YSPSSPNYAP NSPGGASPSY SPTSPGYSPP SPQYSPGSSN YSPSSPNIHS
     ATQNYSPTSP SYSPMSPMHP TSASNFASPG YSPTSPSYSP TSPSYSPSSP VFSPTSPSYS
     PSSPSYSPTS PSYSPTSPSY SPTSPNFTPV TPSYSPSSPN YSPTSPHYSP ASPSYSPSSP
     KYSPTSPSYS PTSPSYIGSP HYTPASPQYG QASPNYSPTS PSYSPSSPQH SPGSSSNHYS
     IGSSSYSQTP APYSPNMSSY SPSSPKYSPT SPVYTSSSPT YSPSSPAYSP TPQGYSPSSP
     ASPTYSPTSP SYDDSNED
//

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