(data stored in ACNUC26462 zone)

SWISSPROT: Q7Q4D2_ANOGA

ID   Q7Q4D2_ANOGA            Unreviewed;       457 AA.
AC   Q7Q4D2;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 4.
DT   11-DEC-2019, entry version 115.
DE   SubName: Full=AGAP008341-PA {ECO:0000313|EMBL:EAA12282.4};
DE   Flags: Fragment;
GN   ORFNames=AgaP_AGAP008341 {ECO:0000313|EMBL:EAA12282.4};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Holometabola; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA12282.4, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|EMBL:EAA12282.4, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA12282.4,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC       {ECO:0000256|RuleBase:RU000304}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAA12282.4}.
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DR   EMBL; AAAB01008964; EAA12282.4; -; Genomic_DNA.
DR   RefSeq; XP_317116.4; XM_317116.4.
DR   STRING; 7165.AGAP008341-PA; -.
DR   PaxDb; Q7Q4D2; -.
DR   GeneID; 1277641; -.
DR   KEGG; aga:AgaP_AGAP008341; -.
DR   eggNOG; KOG0615; Eukaryota.
DR   eggNOG; ENOG410YA63; LUCA.
DR   HOGENOM; HOG000233016; -.
DR   InParanoid; Q7Q4D2; -.
DR   KO; K06641; -.
DR   OrthoDB; 1510589at2759; -.
DR   PhylomeDB; Q7Q4D2; -.
DR   Proteomes; UP000007062; Chromosome 3R.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0044773; P:mitotic DNA damage checkpoint; IBA:GO_Central.
DR   GO; GO:0042770; P:signal transduction in response to DNA damage; IBA:GO_Central.
DR   CDD; cd00060; FHA; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00240; FHA; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q7Q4D2.
DR   SWISS-2DPAGE; Q7Q4D2.
KW   ATP-binding {ECO:0000256|RuleBase:RU000304};
KW   Kinase {ECO:0000256|RuleBase:RU000304};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
KW   Transferase {ECO:0000256|RuleBase:RU000304}.
FT   DOMAIN          74..134
FT                   /note="FHA"
FT                   /evidence="ECO:0000259|PROSITE:PS50006"
FT   DOMAIN          179..443
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   NON_TER         457
FT                   /evidence="ECO:0000313|EMBL:EAA12282.4"
SQ   SEQUENCE   457 AA;  52010 MW;  D0003A6EF2B00EA0 CRC64;
     MEEIATQPLD SETISMDLLT SQTPQSSYGQ LVGNSALFGI IGEFLVLRLA LETRFSCQFQ
     EQFHFVADLC SEKFNVGRDR RCSLAIDEVH FPLPIRSFIS NIHFTLEKDL TDRYTPTYII
     DNSTNGTYVN GKLVGRNNRA ILLPGSTISI ACFANIFVYN QHDYRVPPEV ESQALRKRYH
     IGRTLGSGSF GTVYMLHDVT TCQPYALKIV KKQRYGTKLR GSPSLTNEAN IMKKLNHPCV
     IRMFDFINDP GSISMVLEYM QGGDLLTRIM DNGYLPEDTA KFYFYQLCHA IHYLHSQGIT
     HRDLKPDNVL LKDNDEYTLI KVSDFGSSKF LDHTIFMRTI CGTPEYVAPE VLESNGQKPY
     TRQVDVWSLG VVLYTMLSGL LPFGTMNGMT DAAELVMRGN FSMAQPVWRT VRSFRPKKLI
     YDILNVDPDE RPSVEMLLDS VWFRNSDVVQ HAQAMMN
//

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