(data stored in ACNUC9543 zone)

SWISSPROT: Q7SAB3_NEUCR

ID   Q7SAB3_NEUCR            Unreviewed;      1179 AA.
AC   Q7SAB3;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2003, sequence version 1.
DT   08-MAY-2019, entry version 100.
DE   SubName: Full=ATP-dependent RNA helicase DHX8 {ECO:0000313|EMBL:EAA33344.1};
GN   ORFNames=NCU06318 {ECO:0000313|EMBL:EAA33344.1};
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
OS   1257 / FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA33344.1, ECO:0000313|Proteomes:UP000001805};
RN   [1] {ECO:0000313|EMBL:EAA33344.1, ECO:0000313|Proteomes:UP000001805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC   {ECO:0000313|Proteomes:UP000001805};
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D., FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
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DR   EMBL; CM002239; EAA33344.1; -; Genomic_DNA.
DR   RefSeq; XP_962580.1; XM_957487.2.
DR   EnsemblFungi; EAA33344; EAA33344; NCU06318.
DR   GeneID; 3878714; -.
DR   KEGG; ncr:NCU06318; -.
DR   EuPathDB; FungiDB:NCU06318; -.
DR   HOGENOM; HOG000175261; -.
DR   InParanoid; Q7SAB3; -.
DR   KO; K12818; -.
DR   OMA; RIQKAIC; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0034459; F:ATP-dependent 3'-5' RNA helicase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000390; P:spliceosomal complex disassembly; IBA:GO_Central.
DR   CDD; cd00079; HELICc; 1.
DR   Gene3D; 1.10.10.2130; -; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR042035; DEAH_win-hel_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50126; S1; 1.
PE   4: Predicted;
DR   PRODOM; Q7SAB3.
DR   SWISS-2DPAGE; Q7SAB3.
KW   ATP-binding {ECO:0000256|SAAS:SAAS01176619};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001805};
KW   Helicase {ECO:0000313|EMBL:EAA33344.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01176622};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS01176608};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT   DOMAIN      208    277       S1 motif. {ECO:0000259|PROSITE:PS50126}.
FT   DOMAIN      524    687       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      705    885       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   COILED      427    454       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1179 AA;  132216 MW;  A5F057CF9DE7AEF8 CRC64;
     MDDLESLELL SLVSKVTSEL QNHLGVSEKT LAEFIIAQRV ECGSFDEFKQ KLATIGADFP
     PSLVESIDRL VLTLHPKFKG QNHGQTRADE NEKHGQSAEE KTKVFKGLSI PDKEVDVIDD
     TLALLESLEP KRAEKERPRK RSRTPERDDY ADDYGKRKRK ERYRSRSRSR SRSISPPRGR
     RKGRYDDEYD GDFRRPPPRE VDDSPILYKV YEGHVTGIKD FGAFVNLHGV KGKVDGLVHV
     SAFGQRVNHP SDLLSKGQEV KVKVIKLEGG RVGLSMKDVD QETGMDLAPQ LRIGSGANME
     ALGGRGGYDT KNVVTNGFGD KGAFQATANA RQHKKRMTSP ERWEIRQMIA AGIAKASDYP
     ELEEDYQATL KGEGQMELEE DVDIEVRDEE PPFLAGQTKQ SLELSPIRVV KAPDGSLNRA
     AMAGTNLAKE RKELRQQETE AKKAEEKKVD LSSQWQDPMA NPETRKFASD LRKNAQAAPA
     APDAVPEWKR AVAPKEVSLG RRTNMSIKEQ RESLPVFAFR EQLITAVREN QVLIVVGETG
     SGKTTQLTQY LAEAGFTNNG MIGCTQPRRV AAVSVAKRVS EEVGCQLGQE VGYTIRFEDV
     TSPATKIKYM TDGMLQREIL IDPDLKRYSV IMLDEAHERT IATDVLFALL KKTMKRREDL
     KVIVTSATLD ADKFSEYFNQ CPIFTIPGRT FPVEILYSRE PESDYLDAAL TTVMQIHLSE
     PMGDILLFLT GQEEIDTACE ILYERMKALG PNVPELLILP VYSALPSEMQ SRIFDPAPPG
     SRKVVIATNI AETSITIDHI YYVVDPGFVK QNAYDPKLGM DSLVVTPISQ AQANQRAGRA
     GRTGPGKCFR LYTEAAYQSE MLPTTIPEIQ RQNLSNTILM LKAMGINDLL RFDFMDPPPV
     NTMLTALEEL YALAALDDEG LLTRLGRKMA DFPMEPALAK VLIASVEKGC SDEMVTIVAM
     LNLPNVFYRP KEKQAQADQK KAKFHDPHGD HLTLLNVYNS WKNNGYANPW CFENFIQARS
     MRRAKDVRDQ IVKIMDRHRH PVISCGRDTN KVRQALCAGF FRNAARKDPQ EGYKTLIEGT
     PVYLHPSSAL FGKQAEWVVY HTLVLTTREY MHYTTSIEPK WLVEAAPTFF KMAPTDKLSK
     RKKAERIEPL YNKYAGADDW RLSAQRRGGR GGGGGGTWG
//

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