(data stored in ACNUC31108 zone)

SWISSPROT: Q7T2E0_DANRE

ID   Q7T2E0_DANRE            Unreviewed;       256 AA.
AC   Q7T2E0;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   08-MAY-2019, entry version 108.
DE   RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
GN   Name=cd82b {ECO:0000313|Ensembl:ENSDARP00000116394,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-2857};
GN   Synonyms=cd82 {ECO:0000313|EMBL:AAH54586.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-2857};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH54586.1};
RN   [1] {ECO:0000313|EMBL:AAH54586.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000313|EMBL:AAH54586.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAI64453.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescue {ECO:0000313|EMBL:AAI64453.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000116394}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000116394};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000116394, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000116394,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [5] {ECO:0000313|Ensembl:ENSDARP00000146155}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000146155};
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361218};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361218}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|RuleBase:RU361218, ECO:0000256|SAAS:SAAS01169470}.
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DR   EMBL; BX005470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC054586; AAH54586.1; -; mRNA.
DR   EMBL; BC164453; AAI64453.1; -; mRNA.
DR   RefSeq; NP_997828.1; NM_212663.1.
DR   STRING; 7955.ENSDARP00000116394; -.
DR   Ensembl; ENSDART00000147886; ENSDARP00000116394; ENSDARG00000026070.
DR   Ensembl; ENSDART00000193808; ENSDARP00000146155; ENSDARG00000026070.
DR   GeneID; 324137; -.
DR   KEGG; dre:324137; -.
DR   CTD; 324137; -.
DR   ZFIN; ZDB-GENE-030131-2857; cd82b.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00940000158481; -.
DR   HOGENOM; HOG000230651; -.
DR   KO; K06509; -.
DR   OMA; FYNWTDN; -.
DR   OrthoDB; 1207549at2759; -.
DR   TreeFam; TF352892; -.
DR   PRO; PR:Q7T2E0; -.
DR   Proteomes; UP000000437; Chromosome 18.
DR   Bgee; ENSDARG00000026070; Expressed in 28 organ(s), highest expression level in caudal fin.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q7T2E0.
DR   SWISS-2DPAGE; Q7T2E0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00429796};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00028015};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00429788}.
FT   TRANSMEM     12     34       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM     54     78       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM     85    108       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM    219    242       Helical. {ECO:0000256|RuleBase:RU361218}.
SQ   SEQUENCE   256 AA;  28486 MW;  53AF356167F53066 CRC64;
     MGKGCIAATK YFLFLFNLLF FILGAVIMGF GLWVRLDSQS FLTVLQESST SLKVGAYILI
     GIGSLSMLMG FLGCIGAIYE IRCLLGLYFT CLLLILIAQV TAAVLIYFQR DLLKGETYNI
     VNKILVNYTG SNNTSEDAWD YIQRTMKCCG WSGQSDWKEN VMIKNNSKIL YPCSCRNESI
     SGSDKQEKGF CEGLSPQWPV FTKGCISSLE DWILRNCGVI LGVCVGIAVI ELLGMILSMC
     LCKSVQQEDY TKVPKY
//

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