(data stored in ACNUC4474 zone)

SWISSPROT: Q7T2W4_TAKRU

ID   Q7T2W4_TAKRU            Unreviewed;       440 AA.
AC   Q7T2W4;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   08-MAY-2019, entry version 92.
DE   SubName: Full=Nicotinic acetylcholine receptor alpha 1b subunit {ECO:0000313|EMBL:AAP51164.1};
DE   Flags: Fragment;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|EMBL:AAP51164.1};
RN   [1] {ECO:0000313|EMBL:AAP51164.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=13679024; DOI=10.1016/S0888-7543(03)00153-8;
RA   Jones A.K., Elgar G., Sattelle D.B.;
RT   "The nicotinic acetylcholine receptor gene family of the pufferfish,
RT   Fugu rubripes.";
RL   Genomics 82:441-451(2003).
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane {ECO:0000256|SAAS:SAAS00569352}; Multi-pass membrane
CC       protein {ECO:0000256|SAAS:SAAS00569352}. Cell membrane
CC       {ECO:0000256|SAAS:SAAS00569391}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00569391}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; AY295876; AAP51164.1; -; mRNA.
DR   eggNOG; KOG3645; Eukaryota.
DR   eggNOG; ENOG410XQGR; LUCA.
DR   HOGENOM; HOG000006756; -.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 2.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q7T2W4.
DR   SWISS-2DPAGE; Q7T2W4.
KW   Cell junction {ECO:0000256|SAAS:SAAS00458005};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00458000};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00081591};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00458066};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457919};
KW   Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00172123};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00081626};
KW   Receptor {ECO:0000256|SAAS:SAAS00469528, ECO:0000313|EMBL:AAP51164.1};
KW   Synapse {ECO:0000256|SAAS:SAAS00103537};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081549}.
FT   TRANSMEM    217    240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    252    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    282    304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    413    435       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        9    215       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      223    344       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   DOMAIN      346    430       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:AAP51164.1}.
SQ   SEQUENCE   440 AA;  49850 MW;  6AC1BAC57CB7A2A0 CRC64;
     AAPGASKDET RLVKTLFTGY NKVVRPVTHF KDPVVVTVGL QLIQLINVDE VNQIVSSNVR
     LKQQWKDVNL QWNPDDYGGI KKIRVPSTDI WRPDLVLYNN ADGDFAIVHE TKVLLEHTGM
     ITWNPPAIFK SYCEIIVLHF PFDLQNCSMK LGTWTYDGNL VVVNPDSDRP DLSNFMESGE
     WVMKDFRGWK HWVYYACCPD TPYLDITYHF LMLRLPLYFI VNVIIPCMLF SFLTGLVFYL
     PTDSGEKMTL SISVLLSLTV FLLVIVELIP STSSAVPLIG KYMLFTMVFV IASIIITVIV
     INTHHRSPST HTMPEWVRTV FIETIPNIMF FSTMKRPGKE KQNKSIQPAD FDISEISGNQ
     ATAVPYQTSL TKNPDVRSAI EGVKYIAETM KSDEESNNAA EEWKFVAMVL DHILLCVFMA
     VCLIGTLGVF AGRLIELSML
//

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