(data stored in ACNUC7820 zone)

SWISSPROT: Q7TRG2_MOUSE

ID   Q7TRG2_MOUSE            Unreviewed;       312 AA.
AC   Q7TRG2;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   30-AUG-2017, entry version 119.
DE   RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047};
GN   Name=Olfr845 {ECO:0000313|EMBL:AAP71326.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000071239, ECO:0000313|MGI:MGI:3030679};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000313|EMBL:AAP71326.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA   Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA   Walker M., Williams E.M., Trask B.J.;
RT   "Odorant receptor expressed sequence tags demonstrate olfactory
RT   expression of over 400 genes, extensive alternate splicing and unequal
RT   expression levels.";
RL   Genome Biol. 4:R71.1-R71.13(2003).
RN   [2] {ECO:0000313|EMBL:AAP71326.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sanders K.;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAI27983.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI27983.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000071239, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000071239,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5] {ECO:0000313|Ensembl:ENSMUSP00000071239}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000071239};
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
RN   [6] {ECO:0000313|Ensembl:ENSMUSP00000149986}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000149986};
RG   Ensembl;
RL   Submitted (DEC-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU363047, ECO:0000256|SAAS:SAAS00857205};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363047,
CC       ECO:0000256|SAAS:SAAS00857205}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688, ECO:0000256|SAAS:SAAS00857212}.
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DR   EMBL; AC100506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC127982; AAI27983.1; -; mRNA.
DR   EMBL; AY318021; AAP71326.1; -; Genomic_DNA.
DR   RefSeq; NP_997028.1; NM_207145.2.
DR   UniGene; Mm.377393; -.
DR   STRING; 10090.ENSMUSP00000071239; -.
DR   Ensembl; ENSMUST00000071259; ENSMUSP00000071239; ENSMUSG00000061614.
DR   Ensembl; ENSMUST00000213344; ENSMUSP00000149986; ENSMUSG00000061614.
DR   Ensembl; ENSMUST00000215572; ENSMUSP00000150474; ENSMUSG00000061614.
DR   GeneID; 258249; -.
DR   KEGG; mmu:258249; -.
DR   UCSC; uc009ohg.2; mouse.
DR   CTD; 258249; -.
DR   MGI; MGI:3030679; Olfr845.
DR   eggNOG; ENOG410IVB1; Eukaryota.
DR   eggNOG; ENOG410YBQN; LUCA.
DR   GeneTree; ENSGT00840000129792; -.
DR   HOGENOM; HOG000041364; -.
DR   HOVERGEN; HBG017625; -.
DR   KO; K04257; -.
DR   OMA; TISAECH; -.
DR   OrthoDB; EOG091G0GUN; -.
DR   TreeFam; TF337210; -.
DR   Reactome; R-MMU-381753; Olfactory Signaling Pathway.
DR   Proteomes; UP000000589; Chromosome 9.
DR   GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISA:MGI.
DR   GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q7TRG2.
DR   SWISS-2DPAGE; Q7TRG2.
KW   Cell membrane {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857207};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000256|SAAS:SAAS00857203};
KW   Membrane {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857208};
KW   Olfaction {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857209};
KW   Receptor {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000256|SAAS:SAAS00857193, ECO:0000313|EMBL:AAP71326.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Sensory transduction {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857210};
KW   Transducer {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000256|SAAS:SAAS00857213};
KW   Transmembrane {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000256|SAAS:SAAS00857211};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857194}.
FT   TRANSMEM     26     47       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM     59     78       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM     98    120       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    132    158       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    197    216       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    237    260       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    272    292       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   DOMAIN       41    290       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
SQ   SEQUENCE   312 AA;  34597 MW;  712BC0AA10D78D71 CRC64;
     MESTNQTDAI EFLLLGLSDD PELQPIIFGL FLFMYLVTFL GNLIITLTIS AECHLHTPMY
     FFLSNLSVAD ICISSTTVPK MLLNIQTPDH RITYSGCLTQ ACFVLLFAGL ENCLLAAMAY
     DRYVAICHPL RYTVIMNSCF CSILIVVSLA ISAVNALLLS LMVLHLNFCT EVEIPHFFCE
     LAQIIKLACS DTLINNILIY ISAFMFGGIP FFGIFLSYTE IVSSVLKIPS RQGRHKAFST
     CGSHLSVVSL FYGTGLGVYI SSAVTESPRK TAVASVMYSI VTQMLNPFIY SLRNRDMKEA
     LRKHVGRIAS IV
//

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