(data stored in ACNUC7820 zone)

SWISSPROT: Q7TRJ1_MOUSE

ID   Q7TRJ1_MOUSE            Unreviewed;       308 AA.
AC   Q7TRJ1;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 2.
DT   30-AUG-2017, entry version 118.
DE   RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047};
GN   Name=Olfr128 {ECO:0000313|EMBL:AAP71250.2,
GN   ECO:0000313|Ensembl:ENSMUSP00000079121, ECO:0000313|MGI:MGI:2177511};
GN   ORFNames=mCG_50230 {ECO:0000313|EMBL:EDL23367.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000313|EMBL:EDL23367.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed {ECO:0000313|EMBL:EDL23367.1};
RX   PubMed=12040188; DOI=10.1126/science.1069193;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
RA   Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
RA   Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
RA   Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
RA   Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
RA   Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
RA   Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
RA   Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
RA   Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
RA   Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
RA   Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
RA   Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
RA   Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
RA   Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
RA   Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
RA   Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
RA   Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
RA   Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
RA   Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
RA   Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
RA   Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
RA   Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
RA   Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
RA   Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
RA   Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
RA   Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
RA   Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
RA   Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
RA   Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
RA   Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
RA   Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
RA   Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
RT   "A comparison of whole-genome shotgun-derived mouse chromosome 16 and
RT   the human genome.";
RL   Science 296:1661-1671(2002).
RN   [2] {ECO:0000313|EMBL:AAP71250.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA   Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA   Walker M., Williams E.M., Trask B.J.;
RT   "Odorant receptor expressed sequence tags demonstrate olfactory
RT   expression of over 400 genes, extensive alternate splicing and unequal
RT   expression levels.";
RL   Genome Biol. 4:R71.1-R71.13(2003).
RN   [3] {ECO:0000313|EMBL:AAQ77056.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:AAQ77056.1};
RX   PubMed=14506126; DOI=10.1093/hmg/ddg317;
RA   Amadou C., Younger R.M., Sims S., Matthews L.H., Rogers J.,
RA   Kumanovics A., Ziegler A., Beck S., Lindahl K.F.;
RT   "Co-duplication of olfactory receptor and MHC class I genes in the
RT   mouse major histocompatibility complex.";
RL   Hum. Mol. Genet. 12:3025-3040(2003).
RN   [4] {ECO:0000313|EMBL:AAP71250.2}
RP   NUCLEOTIDE SEQUENCE.
RA   Sanders K.;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AAP71250.2}
RP   NUCLEOTIDE SEQUENCE.
RA   Young J.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:EDL23367.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed {ECO:0000313|EMBL:EDL23367.1};
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|Ensembl:ENSMUSP00000079121, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000079121,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [8] {ECO:0000313|Ensembl:ENSMUSP00000079121}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000079121};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [9] {ECO:0000313|Ensembl:ENSMUSP00000151065}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000151065};
RG   Ensembl;
RL   Submitted (DEC-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU363047, ECO:0000256|SAAS:SAAS00857205};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363047,
CC       ECO:0000256|SAAS:SAAS00857205}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688, ECO:0000256|SAAS:SAAS00857212}.
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DR   EMBL; CR974447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY317924; AAP71250.2; -; Genomic_DNA.
DR   EMBL; AY375030; AAQ77056.1; -; Genomic_DNA.
DR   EMBL; CH466559; EDL23367.1; -; Genomic_DNA.
DR   RefSeq; NP_996552.1; NM_206816.1.
DR   UniGene; Mm.390990; -.
DR   STRING; 10090.ENSMUSP00000079121; -.
DR   Ensembl; ENSMUST00000080231; ENSMUSP00000079121; ENSMUSG00000059030.
DR   Ensembl; ENSMUST00000216440; ENSMUSP00000151065; ENSMUSG00000059030.
DR   GeneID; 383243; -.
DR   KEGG; mmu:383243; -.
DR   UCSC; uc008cnt.1; mouse.
DR   CTD; 383243; -.
DR   MGI; MGI:2177511; Olfr128.
DR   eggNOG; ENOG410IEM2; Eukaryota.
DR   eggNOG; ENOG410YBQN; LUCA.
DR   GeneTree; ENSGT00760000118849; -.
DR   HOGENOM; HOG000041364; -.
DR   HOVERGEN; HBG017625; -.
DR   KO; K04257; -.
DR   OMA; LAWTEMA; -.
DR   OrthoDB; EOG091G0CU6; -.
DR   TreeFam; TF352740; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   Bgee; ENSMUSG00000059030; -.
DR   GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISA:MGI.
DR   GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q7TRJ1.
DR   SWISS-2DPAGE; Q7TRJ1.
KW   Cell membrane {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857207};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000256|SAAS:SAAS00857203};
KW   Membrane {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857208};
KW   Olfaction {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857209};
KW   Receptor {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000256|SAAS:SAAS00857193, ECO:0000313|EMBL:AAP71250.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Sensory transduction {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857210};
KW   Transducer {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000256|SAAS:SAAS00857213};
KW   Transmembrane {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000256|SAAS:SAAS00857211};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857194}.
FT   TRANSMEM     25     49       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    101    120       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    141    161       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    194    216       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    237    260       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    272    292       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   DOMAIN       41    290       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
SQ   SEQUENCE   308 AA;  34354 MW;  0A03D0A10268DC93 CRC64;
     MTPRNMTTMS GFLLMGFSDN HELQILQALL FLLTYLLGSA GNFIIITITT LDPQLQSPMY
     YFLKHLSILD LSSLSVTVPQ YVDSSLARSG YISYGQCMLQ IFFFTGLAWS EVALLTVMSY
     DRYVAICLPL HYEVIMSPRK CTWAVAAVWL SGGISGTLFT ASTLSIRFCG HKIIHQFFCD
     IPQLLKLSCS NDDFGLLKVS TFIAVMGFAC FMGIAFSYGQ IFSTVLRMPS AEGRSKVFST
     CLPHLFVVSF FLSTGICAYL KPTSDSPTTL DFMLSIFYTV LPPTLNPVIY SLRNQSLKRA
     IKKLLLSE
//

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