(data stored in ACNUC15260 zone)

SWISSPROT: Q7TS08_MOUSE

ID   Q7TS08_MOUSE            Unreviewed;       309 AA.
AC   Q7TS08;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   08-MAY-2019, entry version 121.
DE   SubName: Full=MCG141938 {ECO:0000313|EMBL:EDL06817.1};
DE   SubName: Full=Olfactory receptor 295 {ECO:0000313|Ensembl:ENSMUSP00000077542};
DE   SubName: Full=Olfactory receptor Olfr295 {ECO:0000313|EMBL:AAP70840.1};
GN   Name=Olfr295 {ECO:0000313|EMBL:AAP70840.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000077542, ECO:0000313|MGI:MGI:3030129};
GN   Synonyms=Olfr297 {ECO:0000313|MGI:MGI:3030129};
GN   ORFNames=mCG_141938 {ECO:0000313|EMBL:EDL06817.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAP70840.1};
RN   [1] {ECO:0000313|EMBL:EDL06817.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed {ECO:0000313|EMBL:EDL06817.1};
RX   PubMed=12040188; DOI=10.1126/science.1069193;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
RA   Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
RA   Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
RA   Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
RA   Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
RA   Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
RA   Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
RA   Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
RA   Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
RA   Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
RA   Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
RA   Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
RA   Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
RA   Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
RA   Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
RA   Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
RA   Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
RA   Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
RA   Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
RA   Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
RA   Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
RA   Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
RA   Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
RA   Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
RA   Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
RA   Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
RA   Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
RA   Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
RA   Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
RA   Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
RA   Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
RA   Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
RT   "A comparison of whole-genome shotgun-derived mouse chromosome 16 and
RT   the human genome.";
RL   Science 296:1661-1671(2002).
RN   [2] {ECO:0000313|EMBL:AAP70840.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA   Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA   Walker M., Williams E.M., Trask B.J.;
RT   "Odorant receptor expressed sequence tags demonstrate olfactory
RT   expression of over 400 genes, extensive alternate splicing and unequal
RT   expression levels.";
RL   Genome Biol. 4:R71.1-R71.13(2003).
RN   [3] {ECO:0000313|EMBL:AAP70840.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sanders K.;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:EDL06817.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed {ECO:0000313|EMBL:EDL06817.1};
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|Ensembl:ENSMUSP00000077542, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077542,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [6] {ECO:0000313|Ensembl:ENSMUSP00000077542}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077542};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [7] {ECO:0000313|Ensembl:ENSMUSP00000150377}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000150377};
RG   Ensembl;
RL   Submitted (DEC-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00857205}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00857205}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|SAAS:SAAS00857212}.
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DR   EMBL; AC099606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY317388; AAP70840.1; -; Genomic_DNA.
DR   EMBL; CH466543; EDL06817.1; -; Genomic_DNA.
DR   RefSeq; NP_667062.2; NM_146851.2.
DR   RefSeq; XP_006507937.1; XM_006507874.1.
DR   STRING; 10090.ENSMUSP00000134371; -.
DR   DNASU; 258611; -.
DR   Ensembl; ENSMUST00000078447; ENSMUSP00000077542; ENSMUSG00000059319.
DR   Ensembl; ENSMUST00000215365; ENSMUSP00000150377; ENSMUSG00000059319.
DR   GeneID; 258850; -.
DR   KEGG; mmu:258850; -.
DR   UCSC; uc009ifd.1; mouse.
DR   CTD; 258850; -.
DR   MGI; MGI:3030129; Olfr295.
DR   eggNOG; ENOG410IJCG; Eukaryota.
DR   eggNOG; ENOG41120HT; LUCA.
DR   GeneTree; ENSGT00950000182789; -.
DR   HOGENOM; HOG000041364; -.
DR   KO; K04257; -.
DR   OMA; CACIEIL; -.
DR   OrthoDB; 1077347at2759; -.
DR   TreeFam; TF337248; -.
DR   Reactome; R-MMU-381753; Olfactory Signaling Pathway.
DR   Proteomes; UP000000589; Chromosome 7.
DR   GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR   GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q7TS08.
DR   SWISS-2DPAGE; Q7TS08.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00857207};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00857203};
KW   Membrane {ECO:0000256|SAAS:SAAS00857208, ECO:0000256|SAM:Phobius};
KW   Olfaction {ECO:0000256|SAAS:SAAS00857209};
KW   Receptor {ECO:0000256|SAAS:SAAS00857193, ECO:0000313|EMBL:AAP70840.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Sensory transduction {ECO:0000256|SAAS:SAAS00857210};
KW   Transducer {ECO:0000256|SAAS:SAAS00857213};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00857211,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00857194,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     23     46       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     58     76       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     96    117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    156       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    195    217       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    238    258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    270    290       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       39    288       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
SQ   SEQUENCE   309 AA;  34596 MW;  CC42E57F30AF5D0D CRC64;
     MANSTLVPEF FLEVFAETWE LRILLTVLFL LMYLGSLLGN LIIIIATTVD QTLNTPMYFF
     LRNLSILDMG YVSVTVPNAC INSLTDHRSI SLAGCAGQIF LVFFSACVEI QFLTIMAQDR
     YVAICKPLLY AMIMNHQFCV QMTLASLLTS LILASVHTSK TFQLSFCHSN VVSQFFCDIP
     SLLRLSCTDT FINKLLLLLT AIVFSGSCFT FIAISYVRIL STVLKVPVKG ERGKAFSTCV
     PHIIVVSVFL SSGAYVYLKP SAISEIVEDM TLSVFYTIVP PFLNPIIYSL RNKQIKKAVK
     KVIFRFFIV
//

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