(data stored in SCRATCH zone)

SWISSPROT: Q7WAC5_BORPA

ID   Q7WAC5_BORPA            Unreviewed;      1059 AA.
AC   Q7WAC5;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   08-MAY-2019, entry version 80.
DE   RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN   Name=acrB {ECO:0000313|EMBL:CAE36756.1};
GN   OrderedLocusNames=BPP1454 {ECO:0000313|EMBL:CAE36756.1};
OS   Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257311 {ECO:0000313|Proteomes:UP000001421};
RN   [1] {ECO:0000313|Proteomes:UP000001421}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12822 / ATCC BAA-587 / NCTC 13253
RC   {ECO:0000313|Proteomes:UP000001421};
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.,
RA   Harris D.E., Holden M.T., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.M., Temple L., James K., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J.,
RA   Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C.,
RA   Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K.,
RA   Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K.,
RA   Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU364070}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU364070}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division
CC       (RND) (TC 2.A.6) family. {ECO:0000256|RuleBase:RU364070,
CC       ECO:0000256|SAAS:SAAS01080844}.
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DR   EMBL; BX640427; CAE36756.1; -; Genomic_DNA.
DR   RefSeq; WP_010928044.1; NC_002928.3.
DR   EnsemblBacteria; CAE36756; CAE36756; BPP1454.
DR   KEGG; bpa:BPP1454; -.
DR   HOGENOM; HOG000158129; -.
DR   KO; K18138; -.
DR   OMA; LMYMSSS; -.
DR   BioCyc; BPAR257311:G1GSY-1494-MONOMER; -.
DR   Proteomes; UP000001421; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006855; P:drug transmembrane transport; IEA:InterPro.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004764; HAE1.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
DR   TIGRFAMs; TIGR00915; 2A0602; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q7WAC5.
DR   SWISS-2DPAGE; Q7WAC5.
KW   Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW   Cell membrane {ECO:0000256|RuleBase:RU364070};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001421};
KW   Membrane {ECO:0000256|RuleBase:RU364070};
KW   Transmembrane {ECO:0000256|RuleBase:RU364070};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW   Transport {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM     12     33       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    339    359       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    366    390       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    396    416       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    437    458       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    470    497       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    540    556       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    874    891       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    898    918       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    924    945       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    973    993       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM   1005   1031       Helical. {ECO:0000256|RuleBase:RU364070}.
SQ   SEQUENCE   1059 AA;  113775 MW;  05F54F5C0257667B CRC64;
     MTKFFIDRPV FAWVIAIVLM MAGALSILSL PVAQYPNIAP PAISINVTYP GASAQTVQDT
     VVQVIEQQMN GIDNLQYISS ESNSDGSMSI TLTFSQGTNP DTAQVQVQNK LAVAQPLLPL
     EVQQQGIRVT KATKNFLIVA GFVSTDGTMD KSDLADYVAS YIQDPISRTP GVGDFQLFGA
     PYAMRIWISP EKLVNFGLTA SDVTTAIREQ NVQVSSGQLG GQPAVRGQQL NATVIGPSRL
     QTPEAFGRIL LKVNSDGSQV RLKDVASIEL GAQTYAIDSY YNGKPASGLA IKLASGANAL
     DTAQAVRETI NGLKPYFPPG MDVVYPYDTT PFVSLSIEGV VKTLFEAVLL VFLVMYLFLQ
     NVRATLIPTL AVPVVLLGTF GVLAAFGYSI NTLTMFGMVL AIGLLVDDAI VVVENVERVM
     AEEGLSPRQA TRKSMSQITG ALIGIAMVLA VVFVPMAFFG GSTGVIYRQF SITIVSSMVL
     SVVVAIVFTP ALCATMLKPI PKGHHGSKKG FFGRFNRTFE RSSQAYANNV ARSMGRTKRL
     LLIYVVILLG MAWMFMRIPT AFLPDEDQGI LFAQVQAPAG ATSERTQATI DAAVKYLLED
     EKESVASVFA VNGFSFGGRG QNAAILFIKL RDWNERKGAE HRAAAVAARA NAKFRAELRD
     AQAAVFVPPA VMELGNATGF DFQLQDRAGV GHEKLLAARN QLLQEAGASP MLVAVRPNGI
     EDAPQYQLDI DREKARALGV SITEINNTLA TAWGSSYVND FIDRGRVKKV FVQGEASSRM
     LPQDLDKWYV RNNAGDMVPF SAFSSAQWTF GPQKLNRYNG VPSYNIQGQA APGYSSGDAM
     AEMERLADKL PLGIGYDWTG LSFEERLSGA QAPALYAISL IVVFLCLAAL YESWSIPTAV
     MLVVPLGVVG ALLATLTRGL SNDVYFQVGL LTTIGLAAKN AILIVEFAKE HYEEGASLTE
     AAVHAARQRL RPILMTSLAF ILGVVPLAIS TGAGSGSQNA IGTGVIGGML TGTFLAIFFV
     PLFFVLTLRL FKVKRASENR EDDDPHGGAQ PATHGGQPQ
//

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