(data stored in ACNUC1104 zone)

SWISSPROT: Q82GE0_STRAW

ID   Q82GE0_STRAW            Unreviewed;       499 AA.
AC   Q82GE0;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   08-MAY-2019, entry version 101.
DE   SubName: Full=Putative transmembrane efflux protein {ECO:0000313|EMBL:BAC71669.1};
GN   ORFNames=SAVERM_3957 {ECO:0000313|EMBL:BAC71669.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 /
OS   NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC71669.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC71669.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C.,
RA   Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T.,
RA   Kikuchi H., Shiba T., Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces
RT   avermitilis: deducing the ability of producing secondary
RT   metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC71669.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; BA000030; BAC71669.1; -; Genomic_DNA.
DR   STRING; 227882.SAV_3957; -.
DR   EnsemblBacteria; BAC71669; BAC71669; SAVERM_3957.
DR   KEGG; sma:SAVERM_3957; -.
DR   eggNOG; ENOG4105EDF; Bacteria.
DR   eggNOG; ENOG410XQZX; LUCA.
DR   HOGENOM; HOG000239124; -.
DR   OMA; GFYLFMS; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q82GE0.
DR   SWISS-2DPAGE; Q82GE0.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000428};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091, ECO:0000256|SAM:Phobius,
KW   ECO:0000313|EMBL:BAC71669.1};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     20     40       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     60     77       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     89    112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    150    173       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    179    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    210    228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    240    257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    278    301       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    313    330       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    363       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    375    398       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    419    438       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    458    480       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       22    484       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   499 AA;  52226 MW;  F580C79D5469F2CF CRC64;
     MNVTRTGEST YVLDPDPRRW WSLVVIALAQ LMVVLDATIV NIALPSAQRA LGMSDGNRQW
     VITAYTLAFG GLLLLGGRIA DLVGRKRTFI IGLIGFAAAS ALGGAATTSG MLFGARALQG
     AFAAVLAPSA LSLLTTTFTD PKERGKAFGI YSALAGSGSA IGFIAGGLLT EYLNWRWCLY
     VNIPIAVIAV CGAFALLHEQ PRHAGARLDV PGALLGCGGL VAIVYGFSEA EPRGWTDPRV
     LALFAVGIVL LAVFVWWQTR APQPLLPLHI VKDRNRAGCF LTMALAVIGL FGMFLFLTYY
     LQVVLGYSPL KTGLAFLPLT VAIIIGSTQI SARLMSHVAP RLLMVPGTVL AAGGMLVLTR
     ITVHSPYASE LLPALILIGL GMGLTFMPVF ATATAGVAPQ DSGVTSATVN TAQQVGGSIG
     TALLNTIATT TSTAYIAAHL RDPARKELVI REGIVHGYTV AIWCAAGVML LAGLAAGLMV
     TTKPPRHTPS DTPVPESVG
//

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