(data stored in SCRATCH zone)

SWISSPROT: Q82RK9_STRAW

ID   Q82RK9_STRAW            Unreviewed;       460 AA.
AC   Q82RK9;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   08-MAY-2019, entry version 110.
DE   RecName: Full=Histidine kinase {ECO:0000256|SAAS:SAAS00924638};
DE            EC=2.7.13.3 {ECO:0000256|SAAS:SAAS00924638};
GN   ORFNames=SAVERM_134 {ECO:0000313|EMBL:BAC67843.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 /
OS   NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC67843.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC67843.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C.,
RA   Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T.,
RA   Kikuchi H., Shiba T., Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces
RT   avermitilis: deducing the ability of producing secondary
RT   metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC67843.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; BA000030; BAC67843.1; -; Genomic_DNA.
DR   STRING; 227882.SAV_134; -.
DR   EnsemblBacteria; BAC67843; BAC67843; SAVERM_134.
DR   KEGG; sma:SAVERM_134; -.
DR   HOGENOM; HOG000253807; -.
DR   OMA; ARTHNEM; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; Q82RK9.
DR   SWISS-2DPAGE; Q82RK9.
KW   ATP-binding {ECO:0000256|SAAS:SAAS01002602};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000428};
KW   Kinase {ECO:0000256|SAAS:SAAS00924871, ECO:0000313|EMBL:BAC67843.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS01002785};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00924820};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    460       Histidine kinase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5004297534.
FT   TRANSMEM    141    162       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      167    219       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      227    427       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   460 AA;  48496 MW;  45C5D7274B0CC4C3 CRC64;
     MRQRVVRVAL TAVLVAMVLL AVPLALAIRF SLYADQRDAL ERAALAGAVR VSPDYATGDP
     VELPPPPDGG RLGLYDPQLR LRAGSGPRIG DDTARRALTG TVTRSTGGGE LVAAVPVSHD
     EQVIGVVRVS SAVQDVRDRI LVGWALLLGV AVLALTVAVL VARRQARALA APLEDLSRHC
     RAVTGGDLTA RAAPSAIGEI DQVARTHNEM LHSLAELLLR ERNFTANASH QLRTPLTGLQ
     LTLEAGLEHD DTRPVLEEAL AATRRLHHTV EEVLRLSGSA GLPQPVAPDR PVTGLLRETE
     ERWHGLFARE GRRLECDTGE VPDDVRVPGG PVAEILGVLL DNARVHGHGT VRVTVRDLDD
     ALALDIADEG TADGDSARLF ERGHTEGGAG TGIGLSLARD LAVSLGGRLS LANRAPTTFT
     LLLPVRAAGG HGAEDRNESD GRRGDGDPQD EAGQGGPGGR
//

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