(data stored in SCRATCH zone)

SWISSPROT: Q82RS1_STRAW

ID   Q82RS1_STRAW            Unreviewed;       551 AA.
AC   Q82RS1;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   08-MAY-2019, entry version 118.
DE   SubName: Full=Putative two-component system sensor kinase {ECO:0000313|EMBL:BAC67781.1};
GN   ORFNames=SAVERM_72 {ECO:0000313|EMBL:BAC67781.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 /
OS   NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC67781.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC67781.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C.,
RA   Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T.,
RA   Kikuchi H., Shiba T., Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces
RT   avermitilis: deducing the ability of producing secondary
RT   metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC67781.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; BA000030; BAC67781.1; -; Genomic_DNA.
DR   STRING; 227882.SAV_72; -.
DR   EnsemblBacteria; BAC67781; BAC67781; SAVERM_72.
DR   KEGG; sma:SAVERM_72; -.
DR   eggNOG; ENOG4105GR3; Bacteria.
DR   eggNOG; COG0642; LUCA.
DR   HOGENOM; HOG000223177; -.
DR   OMA; SRMAVET; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; Q82RS1.
DR   SWISS-2DPAGE; Q82RS1.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000428};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:BAC67781.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     61     79       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      250    303       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      311    530       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   551 AA;  58293 MW;  7CDA720AE8FA20AF CRC64;
     MTDVPNGRDP NGRDPNGRRA LVPASPPGML RRLQRARLLP RSVRVLRSLR VLPRSVRARS
     ALAAAFAAAV LFTSGALLMR HQLYDERLRA TSSVAQQQVT TLLSATANSS ISGPWGAPYE
     IVAGDGMLLA SSPELEPYEK DGHAFLTGPG RGGSLPLYTR RRFTFPAVAE PAARSLSGQT
     LTTVEGTVPA SYLPGETQGR GVAAGARVRV YVLIVPDDAE RAVGELDREL VVAVPLATAL
     VAGVAWLATR RALRPVEAIR ARTASVTAAD PRERVEVPDT ADEVAELALT INATLQRLEE
     AATAQRRFVA DAAHELRSPL ATLLAGLEVA TAYPDRADWP AVVSAAGRQA RRLSGLTEEL
     LLLARLDAGA PPAPAERVDV AALAGRLSEE YAERAGGSPK VDLLVAAPDA ATTVFAAPGD
     LERILRNLLD NALRHAVGRV LLTVARDSAA PGSVLCTVRD DGAGVAEADS ERIFERFTRL
     DESRTRTDGG TGLGLAIARD LAARHGGLLV LAVQPKGSGA CFVLRLPAGD PMSIRPRPFK
     GRGRSARSQR L
//

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