(data stored in ACNUC31108 zone)

SWISSPROT: TSN9_MOUSE

ID   TSN9_MOUSE              Reviewed;         239 AA.
AC   Q8BJU2; Q3TQQ0;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 118.
DE   RecName: Full=Tetraspanin-9;
DE            Short=Tspan-9;
DE   AltName: Full=Tetraspan NET-5;
GN   Name=Tspan9; Synonyms=Net5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, and Visual cortex;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION IN A COMPLEX WITH GP6, SUBCELLULAR LOCATION,
RP   GLYCOSYLATION, AND TISSUE SPECIFICITY.
RX   PubMed=18795891; DOI=10.1042/BJ20081126;
RA   Protty M.B., Watkins N.A., Colombo D., Thomas S.G., Heath V.L.,
RA   Herbert J.M., Bicknell R., Senis Y.A., Ashman L.K., Berditchevski F.,
RA   Ouwehand W.H., Watson S.P., Tomlinson M.G.;
RT   "Identification of Tspan9 as a novel platelet tetraspanin and the
RT   collagen receptor GPVI as a component of tetraspanin microdomains.";
RL   Biochem. J. 417:391-400(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Heart, Kidney, Liver, Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Found in a complex with GP6.
CC       {ECO:0000269|PubMed:18795891}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:18795891};
CC       Multi-pass membrane protein {ECO:0000305|PubMed:18795891}.
CC       Note=Colocalizes with GP6 in tetraspanin microdomains on the
CC       platelet surface.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in megakaryocytes,
CC       platelets and lung. Weakly expressed in bone marrow, brain and
CC       kidney (at protein level). {ECO:0000269|PubMed:18795891}.
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:18795891}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000305}.
DR   EMBL; AK079139; BAC37559.1; -; mRNA.
DR   EMBL; AK158729; BAE34632.1; -; mRNA.
DR   EMBL; AK163395; BAE37332.1; -; mRNA.
DR   EMBL; BC052503; AAH52503.1; -; mRNA.
DR   CCDS; CCDS20568.1; -.
DR   RefSeq; NP_780623.1; NM_175414.4.
DR   RefSeq; XP_006505396.1; XM_006505333.3.
DR   RefSeq; XP_006505398.1; XM_006505335.2.
DR   SMR; Q8BJU2; -.
DR   STRING; 10090.ENSMUSP00000107794; -.
DR   iPTMnet; Q8BJU2; -.
DR   SwissPalm; Q8BJU2; -.
DR   jPOST; Q8BJU2; -.
DR   MaxQB; Q8BJU2; -.
DR   PaxDb; Q8BJU2; -.
DR   PeptideAtlas; Q8BJU2; -.
DR   PRIDE; Q8BJU2; -.
DR   Ensembl; ENSMUST00000032503; ENSMUSP00000032503; ENSMUSG00000030352.
DR   Ensembl; ENSMUST00000112171; ENSMUSP00000107794; ENSMUSG00000030352.
DR   Ensembl; ENSMUST00000112173; ENSMUSP00000107796; ENSMUSG00000030352.
DR   GeneID; 109246; -.
DR   KEGG; mmu:109246; -.
DR   UCSC; uc009eco.1; mouse.
DR   CTD; 10867; -.
DR   MGI; MGI:1924558; Tspan9.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00940000158225; -.
DR   HOGENOM; HOG000230651; -.
DR   InParanoid; Q8BJU2; -.
DR   KO; K17350; -.
DR   OMA; YEGYATL; -.
DR   OrthoDB; 1224210at2759; -.
DR   PhylomeDB; Q8BJU2; -.
DR   TreeFam; TF352892; -.
DR   ChiTaRS; Tspan9; mouse.
DR   PRO; PR:Q8BJU2; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   Bgee; ENSMUSG00000030352; Expressed in 291 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; Q8BJU2; baseline and differential.
DR   Genevisible; Q8BJU2; MM.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0097197; C:tetraspanin-enriched microdomain; ISO:MGI.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q8BJU2.
DR   SWISS-2DPAGE; Q8BJU2.
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    239       Tetraspanin-9.
FT                                /FTId=PRO_0000219254.
FT   TOPO_DOM      1     13       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     14     34       Helical. {ECO:0000255}.
FT   TOPO_DOM     35     55       Extracellular. {ECO:0000255}.
FT   TRANSMEM     56     76       Helical. {ECO:0000255}.
FT   TOPO_DOM     77     85       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     86    106       Helical. {ECO:0000255}.
FT   TOPO_DOM    107    203       Extracellular. {ECO:0000255}.
FT   TRANSMEM    204    224       Helical. {ECO:0000255}.
FT   TOPO_DOM    225    239       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD    180    180       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:18795891}.
SQ   SEQUENCE   239 AA;  26738 MW;  B3DC47ADA1D877DD CRC64;
     MARGCLCCLK YTMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS LSAANLVIAI
     GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LIILLAELIL IILFFVYMDK VNENAKQDLK
     EGLLLYNTEN NVGLKNAWNI IQAEMRCCGV TDYTDWYPVL GENTVPDRCC MENSQGCGRN
     STTPLWRTGC YEKVKLWFDD NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDA
//

If you have problems or comments...

PBIL Back to PBIL home page