(data stored in ACNUC22857 zone)

SWISSPROT: Q8I3I6_PLAF7

ID   Q8I3I6_PLAF7            Unreviewed;       929 AA.
AC   Q8I3I6;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 2.
DT   07-JUN-2017, entry version 105.
DE   RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN   ORFNames=PF3D7_0528100 {ECO:0000313|EMBL:CAD51642.2};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51642.2, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|EMBL:CAD51642.2, ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00556307}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|PIRNR:PIRNR002291}.
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DR   EMBL; AL844504; CAD51642.2; -; Genomic_DNA.
DR   RefSeq; XP_001351835.2; XM_001351799.2.
DR   ProteinModelPortal; Q8I3I6; -.
DR   SMR; Q8I3I6; -.
DR   IntAct; Q8I3I6; 2.
DR   MINT; MINT-1744951; -.
DR   EnsemblProtists; CAD51642; CAD51642; PF3D7_0528100.
DR   GeneDB; PF3D7_0528100.1:pep; -.
DR   GeneID; 813094; -.
DR   KEGG; pfa:PFE1400c; -.
DR   EuPathDB; PlasmoDB:PF3D7_0528100; -.
DR   HOGENOM; HOG000163270; -.
DR   InParanoid; Q8I3I6; -.
DR   KO; K12392; -.
DR   OMA; ARASMVW; -.
DR   PhylomeDB; Q8I3I6; -.
DR   Reactome; R-PFA-8866427; VLDLR internalisation and degradation.
DR   Reactome; R-PFA-8964038; LDL clearance.
DR   Proteomes; UP000001450; Chromosome 5.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0008565; F:protein transporter activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; ISS:GeneDB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 2.60.40.1150; -; 1.
DR   InterPro; IPR026739; AP_beta.
DR   InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015151; B-adaptin_app_sub_C.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR013037; Clathrin_b-adaptin_app_Ig-like.
DR   InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR   InterPro; IPR013041; Coatomer/clathrin_app_Ig-like.
DR   PANTHER; PTHR11134; PTHR11134; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF09066; B2-adapt-app_C; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SMART; SM01020; B2-adapt-app_C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49348; SSF49348; 1.
DR   SUPFAM; SSF55711; SSF55711; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8I3I6.
DR   SWISS-2DPAGE; Q8I3I6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Membrane {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00101884};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00468902};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transport {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00299740}.
FT   DOMAIN      812    923       B2-adapt-app_C. {ECO:0000259|SMART:
FT                                SM01020}.
SQ   SEQUENCE   929 AA;  106154 MW;  47F294F26E40E3F4 CRC64;
     MSDLRYFQTT KKGEIHELKE ELHSSHKEKK KEAIKKIIAA MTVGKDVSTL FSDVVNCMQT
     SNIELKKLVY LYVINYAKVQ PELAILAVNT FRKDSSDPNP LIRALAIRTM GCIRLEQITE
     YLIEPLRRCL KDEDPYVRKT AVICIAKLYD ISPKLVEEEG FIDTLLDILD DNNAMVVANA
     VISLTDICEN SNKSILKDVI NKDENNVNKL LNAINECVEW GQVFILDALV LYEPKTSKDA
     ERVLERILPR LSHANSAVVL SSIKVILCLL DKINDKEFIK NVHKKLSPSL VTLLSAEPEI
     QYIALRNINL ITQKLPNMLS DKINMFFCKY NEPAYVKMEK LDIIIRLVSD KNVDLVLYEL
     KEYSTEVDVE FVKKSVRAIG SCAIKLPQSS EKCINILLDL IDTKINYVIQ ECIVVIKDIF
     RKYPNKYESI ITILCENLES LDESNAKASL IWIIGEYVER IDNADELIDS FLENFSDEPY
     NVQLQILTAS VKLFLKCSKN TKDIITKVLK LSTEESDNPD LRDRAYIYWR LLSKNIDVAK
     KIVLADKPPI QEENKITDTK VLNKLIKNIS MLSSVYHKLP ETFISKKNSY SLNSDNNNDH
     MQDDHYDDDD YDKDNHVLKI KKQMDKQKYD SYSSDNKKSN HSKSSSDSYN NSSDEFNNDI
     DDADDSKKSM DLIGLNDDES KPQKTIPPVK MVQVLSSEDA GLKGQTGLSI FASINRIDRK
     IQLKISVTNQ TQNEIVVSGV QINKNSFGLS SPNNLDVQNI GFGETKEMLI YLIPNTLNSN
     TPPATPLFLQ VAIRTNLDIF YFNVPYDIFV VFVENFHMEK DIFKKKWQII EEAKESILMA
     VSPMVITSDM LIKRMKIFNI SLIARRNVNN MELYYFACIT TNNLVILSEV TIQPEKKNVK
     LCIRTDSSSV IPLYKLLFVK AFSLSVTQT
//

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