(data stored in SCRATCH zone)

SWISSPROT: Q8I6S5_PLAF7

ID   Q8I6S5_PLAF7            Unreviewed;      1038 AA.
AC   Q8I6S5;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 104.
DE   SubName: Full=2-oxoglutarate dehydrogenase E1 component {ECO:0000313|EMBL:CAD51167.1};
DE            EC=1.2.4.2 {ECO:0000313|EMBL:CAD51167.1};
GN   ORFNames=PF3D7_0820700 {ECO:0000313|EMBL:CAD51167.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51167.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51167.1; -; Genomic_DNA.
DR   RefSeq; XP_001349318.1; XM_001349282.1.
DR   SMR; Q8I6S5; -.
DR   IntAct; Q8I6S5; 2.
DR   SwissPalm; Q8I6S5; -.
DR   PRIDE; Q8I6S5; -.
DR   EnsemblProtists; CAD51167; CAD51167; PF3D7_0820700.
DR   GeneDB; PF3D7_0820700.1:pep; -.
DR   GeneID; 2655496; -.
DR   KEGG; pfa:PF3D7_0820700; -.
DR   EuPathDB; PlasmoDB:PF3D7_0820700; -.
DR   HOGENOM; HOG000259586; -.
DR   InParanoid; Q8I6S5; -.
DR   KO; K00164; -.
DR   OMA; GYYDYVR; -.
DR   PhylomeDB; Q8I6S5; -.
DR   Reactome; R-PFA-389661; Glyoxylate metabolism and glycine degradation.
DR   Reactome; R-PFA-71064; Lysine catabolism.
DR   Reactome; R-PFA-71403; Citric acid cycle (TCA cycle).
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:GeneDB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0045252; C:oxoglutarate dehydrogenase complex; IBA:GO_Central.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; ISS:GeneDB.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006103; P:2-oxoglutarate metabolic process; ISS:GeneDB.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; ISS:GeneDB.
DR   Gene3D; 3.40.50.11610; -; 1.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   PANTHER; PTHR23152; PTHR23152; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   TIGRFAMs; TIGR00239; 2oxo_dh_E1; 1.
PE   4: Predicted;
DR   PRODOM; Q8I6S5.
DR   SWISS-2DPAGE; Q8I6S5.
KW   Oxidoreductase {ECO:0000313|EMBL:CAD51167.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          650..860
FT                   /note="Transket_pyr"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   1038 AA;  121150 MW;  8359B70B2C2F2A36 CRC64;
     MRKFFYTNNL VRNNGKDIRT RSFHLSSCLY DYNFNPSMTS YIENTYKIWK EDRNNLHKSW
     DSLFSMYPHA EMDNYNNPIK INRKTDNYNN SNCFQDVLKN NNLRITYVNN EMLEKGKTEN
     IYDLARIVQL IRWYQKKGHL YANINPLPLP KEPPYSSVCY EPCKRKMSYV DFGFNEDDLD
     KEFFFDLPSI SGFSSNGMKK CNLRNLLKRL EETYCGTIGF EYMHITNENI VNYIIQRIEK
     DKKYEYDTKM KKRILEYTAR AFIFENYMAA KFATTKRFGV DGCETLITGM KALIKRAAQL
     DVDSVLMSMS HRGRLNVLFN VLHKPLEQMM SEFRGKTGFS DNIWGNTGDV KYHLGVEIDY
     YDEDSQRYIH MGIVDNSSHL ESVDPILMGQ ARAQQYYCND KEKKKVLPIT IHGDASIAGQ
     GIAYETFQMS KLPSYNVGGT IHIVVNNQIG FTTYPIDARS GKYCTDIAKC IDIPIIHVNA
     DDPEAVTYVF ELALDIRNKF NIDTIIDIVG YRRFGHNELD MPKFTNPLLY DVIARHKSVL
     DIYSKKLIDE NIISLKEFED NKTEIFNFYE QVYEKSKSFV PTPKEKYLPQ WEHMVTPQKF
     SPSRKTGVEK DVLINLGKKI FTLRENFTAH PIITKLFKSR IDSLETGKNI DFGTAELLAY
     ATLLSDGFHA RLSGQDSQRG TFSHRHAVLH DQITYESYNI FDSLKTPHTI EVNNSLLSEY
     ACLGYEIGYS YEHPDALVIW EAQFGDFANG AQVMIDNYIA SGETKWNKQS GIVMLLPHGY
     DGQGPEHSSA RIERFLQLCD DREDIATYSV EKDNKIIQQH NMQVINCSKP SNFFHALRRQ
     MHRSFRKPLI VITPKKMLKM RMAFDKIENF LTNTEFLPYL PEEVGHKLKD KKEIKRIILC
     SGQVYYDLLN YRYTNKIDDV AIARIEQLSP FPFKQIMNDL QTYPNLRDII WAQEEHMNMG
     PWFYVSRRIE ASIKQLKKDK PKWNIQIPQV RYSGRDVYAA QSAGDLNLHL YQLDEFLVDA
     FNLDKKYNMH VQKYTDAL
//

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