(data stored in SCRATCH zone)

SWISSPROT: Q8IAK1_PLAF7

ID   Q8IAK1_PLAF7            Unreviewed;      2120 AA.
AC   Q8IAK1;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 85.
DE   SubName: Full=Erythrocyte membrane protein 1, PfEMP1 {ECO:0000313|EMBL:CAD51363.1};
GN   ORFNames=PF3D7_0800100 {ECO:0000313|EMBL:CAD51363.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51363.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51363.1; -; Genomic_DNA.
DR   RefSeq; XP_001349514.1; XM_001349478.1.
DR   PRIDE; Q8IAK1; -.
DR   EnsemblProtists; CAD51363; CAD51363; PF3D7_0800100.
DR   GeneDB; PF3D7_0800100.1:pep; -.
DR   GeneID; 4794199; -.
DR   KEGG; pfa:PF3D7_0800100; -.
DR   EuPathDB; PlasmoDB:PF3D7_0800100; -.
DR   HOGENOM; HOG000115239; -.
DR   KO; K13850; -.
DR   OMA; KITATHN; -.
DR   PhylomeDB; Q8IAK1; -.
DR   Reactome; R-PFA-114608; Platelet degranulation.
DR   Reactome; R-PFA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0020002; C:host cell plasma membrane; TAS:GeneDB.
DR   GO; GO:0020030; C:infected host cell surface knob; TAS:GeneDB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0050839; F:cell adhesion molecule binding; TAS:GeneDB.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0020033; P:antigenic variation; TAS:GeneDB.
DR   GO; GO:0098609; P:cell-cell adhesion; TAS:GeneDB.
DR   GO; GO:0020035; P:cytoadherence to microvasculature, mediated by symbiont protein; TAS:GeneDB.
DR   GO; GO:0020013; P:modulation by symbiont of host erythrocyte aggregation; TAS:GeneDB.
DR   GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR   InterPro; IPR041480; CIDR1_gamma.
DR   InterPro; IPR004258; DBL.
DR   InterPro; IPR008602; Duffy-antigen_binding.
DR   InterPro; IPR029211; PfEMP1_ATS.
DR   InterPro; IPR029210; PfEMP1_NTS.
DR   Pfam; PF15445; ATS; 1.
DR   Pfam; PF18562; CIDR1_gamma; 1.
DR   Pfam; PF05424; Duffy_binding; 2.
DR   Pfam; PF15447; NTS; 1.
DR   Pfam; PF03011; PFEMP; 2.
PE   4: Predicted;
DR   PRODOM; Q8IAK1.
DR   SWISS-2DPAGE; Q8IAK1.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN       17     53       NTS. {ECO:0000259|Pfam:PF15447}.
FT   DOMAIN      584    729       PFEMP. {ECO:0000259|Pfam:PF03011}.
FT   DOMAIN     1335   1386       CIDR1_gamma. {ECO:0000259|Pfam:PF18562}.
FT   DOMAIN     1402   1539       PFEMP. {ECO:0000259|Pfam:PF03011}.
FT   DOMAIN     1650   2120       ATS. {ECO:0000259|Pfam:PF15445}.
FT   COILED      225    248       {ECO:0000256|SAM:Coils}.
FT   COILED     1215   1235       {ECO:0000256|SAM:Coils}.
FT   COILED     1993   2013       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2120 AA;  241469 MW;  A85F7C2F156BFFEB CRC64;
     MAAAGGGGKD KYKNAQDAKH LLDIIGEDIY KIANDAALKR SGSELKGLLS LAKFEKNPPD
     KQTPEDPCDL DYKYHTNVTS NVIEPCNKRS GKRFSEVSGA ECANNRIKGN KGSNGDACAP
     FRRLHVCDRN LEQIDPAKIT ATHNLLVDVC QAAKFEGQSI TQDYPKYLAT YNDSPSQICT
     MLARSFADIG DIVRGKDLFR GYDDEEKNRR KKLEQKLKVI FGHIYEELKK HKKLKEEAEE
     RYKKDGDNYY KLREDWWALN RQEIWKAITC GHPGGTYFRQ TACGGGTTPT PNKCRCATND
     VPTYFDYVPQ YLRWFEEWAE DFCRKRKYKL ENAIEKCRGK TKGEKYCDLN GFDCTQTASG
     EKKFVKGHNC HNCSVTCIPF GPWIDNQKKE FLKQRNKYQN EISSNSRKKR STSNNNYKGY
     DEEFYKILKE DYGDVEQFLE KLSREGICQS QPTVGNQKAD AANFTKDNPA KTFSHTEYCQ
     ACPWCGVVCK SGNCTKNPEG SCTEQIRKKV YDDSNTTTIP VLTPEKGKTS ILQKYKTFCE
     KPEKHNQINN WECHYEKTDI SNNCILGKWE KFQKGQEVMV YHPFFWKWVT EMLDDSIKWR
     KELDNCLKNE NKQCISKCNG KCDCYKRWVE QKKEKEWTQI KDHFGKQEDM KEQIRGADPG
     IILEGVLDIE DLFENIKDTY GDVKEIDHIK KLLEEETTVD ADNQNKTTID KLLDHEDKDA
     KGCLQKQNEC KEQERDGGAR SDSQEPTPRS EVKPDSEDLD DDDEDDPDEE KSEEVENPED
     QGEEEGTKQG SGEKKVDGTE AVQETVAEVT PEKKDEVNPC EIVKTLFEKP ENLSDACGLK
     YGPGGKERYS QWKCIPTKPN SDNKGEVGSA GRVARSAPSG EKGSICVPPR RRRLYVKDLE
     TLGDSEVTQV QLRDAFIKCA AVETFFLWDR YKKEKEKKKP QEGVLQLLGT VGTPPTDDEE
     DPPEKMLQKG EIPEEFKRQM FYTLADYKDI LFGDQEVIKT LKDSGDENIK DISEKIKKTL
     NGDNNQESGS SPSLSGKKTT PKDWWETYGK DIWEGMVCAL TYKNSGDKKI EQVKTADDGE
     DLFQKLKTQY EYNTVTLKDE NSGTEGAKPF TPKTVSSSSG EKNPPKLSDF VLRPPYFRYL
     EEWGETFCRQ RARMLDKIKK DCNVEENDNR PGGGITKQYS GDGESCKDYL PDDPTTLPDL
     VSSCPKSCSS YRKWINKKKD EFVEQQNAYT EQQNKCQSKS DKAKSDNGFY TRLQNLPDAA
     AFLKTLGSCS KNDIPEYKID FDVNGETFRY EKYCGTCPEF KINCTKVKCT SGDMQNGCKD
     NKINAANFKT MAQSTEINML VSDNSGNGSQ NDLKDCKTSG IFKGFREDVW TCGKVCGYNV
     CKPKNVNGQN GDGNQILLFN ALLKRWVEYF LEDYKKIKHK ISHCKNSSEG HTCIKNCVEQ
     WISTKRTEWE TIRGRFNDQY KSNDSDVYPV RSFLETWIPK IPVANANNDG KKLIKLSKFD
     NFCSCSASAH SPNGKDDAID CMINRLQDKI DKCKEKHPQP SAENQTTCDE STLVEDVDDY
     EEQNPENKVG KPAICGNVDT TEPVKEEDEE ECKAAESPAE PEQAAEEESV PAAETKDTEN
     QPPQAPDVGP PPLAPAPADQ PLDPTILQTT IPFGIAIALT SIVFLFLKKK TKSTIDLLRV
     INIPKSDYDI PTKLSPNRYI PYTSGKYRGK RYIYLEGDSG TDSGYTDHYS DITSSSESEY
     EELDINDIYV PRAPKYKTLI EVVLEPSGNN TTASGNNTTA SDTQNDIQND IPSDIPKTPS
     DTPPPITDDE WNQLKDEFIS QYLQSEQPKD VPNDYSSGDI PLNTQPNTLY FDKPQEKPFI
     TSIHDRNLYS GEEYNYDMFN SGKNGPYSDK NDLYSGNHDS LSGNRDPTSA NHDSYSGNHH
     PYSGIDLIND SISGNQHIDI YDELLKRKEN ELFGTNNPKR TSTYSVAKLT NSDPIHNQLE
     LFHTWLDRHR DMCEKWENHH ERLAKLKEEW ENETHSGNTH PSDSNKTLNT DVSIQIDMDH
     EKRMKEFTNM DTILEDLDKP FNEPYYYDMY DDDIYYDVND HDTSTVDSNA MDVPSKVQIE
     MDVNTKLVKE KYPIGDVWDI
//

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