(data stored in SCRATCH zone)

SWISSPROT: Q8IAR1_PLAF7

ID   Q8IAR1_PLAF7            Unreviewed;      1321 AA.
AC   Q8IAR1;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 108.
DE   SubName: Full=DNA helicase PSH3 {ECO:0000313|EMBL:CAD51300.1};
DE            EC=3.6.4.12 {ECO:0000313|EMBL:CAD51300.1};
GN   ORFNames=PF3D7_0807100 {ECO:0000313|EMBL:CAD51300.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51300.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51300.1; -; Genomic_DNA.
DR   RefSeq; XP_001349451.1; XM_001349415.1.
DR   SMR; Q8IAR1; -.
DR   EnsemblProtists; CAD51300; CAD51300; PF3D7_0807100.
DR   GeneDB; PF3D7_0807100.1:pep; -.
DR   GeneID; 2655311; -.
DR   KEGG; pfa:PF3D7_0807100; -.
DR   EuPathDB; PlasmoDB:PF3D7_0807100; -.
DR   InParanoid; Q8IAR1; -.
DR   OMA; CYYTSSK; -.
DR   BioCyc; PLASMO:PF08_0111-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0000346; C:transcription export complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   4: Predicted;
DR   PRODOM; Q8IAR1.
DR   SWISS-2DPAGE; Q8IAR1.
KW   ATP-binding {ECO:0000313|EMBL:CAD51300.1};
KW   Helicase {ECO:0000313|EMBL:CAD51300.1};
KW   Hydrolase {ECO:0000313|EMBL:CAD51300.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:CAD51300.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          49..77
FT                   /note="Q_MOTIF"
FT                   /evidence="ECO:0000259|PROSITE:PS51195"
FT   DOMAIN          86..360
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          709..853
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          418..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          623..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           49..77
FT                   /note="Q motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT   COMPBIAS        419..438
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1321 AA;  157197 MW;  BDEAC35904913AB3 CRC64;
     MSNEPVSLIS LNKMLRKNKE EEKHKNVDNT ELTNLVLNTS NYNKKEEKGT FEELNVSIEI
     IRALKRINIY YPSVIQYMIM KKLICKDKKE KKRNCIIQSR NGTGKSMSIC IIIINQIFCK
     MKKKKETEQN NKNKKEEIGK IDYSKYVSDH ISQSISDNEN IFFGFLFFYG LILEPTRELC
     QQVYDNIKKI TNILRNEDDE DIYDNKNGLD VYNNICTNRC EKKYVNYYKI KSLILYGGTD
     IFESIKTLFY NFPHIIISTP GRLKHVLNIL NKVKIEINKE DKITNKGIYP LSYITIINIC
     LNYFILDEID ALLDEQFDEQ LKIIYNYIVN PKIQILCYSS TFQDACINNF IQKVIECDER
     YVARLQRVHM SNMDHTNYKD DGNDYLKMGL DNEQQHCGKE NKMVDEYITD EHNINKNKNK
     NNVDINKNKN NVDINKNNGD INKNNVDINK NNGDINKNNV DINKNNVDIN KNNGDINKNN
     GDINKNNGDI NKNNGDINKN NGDINKNNGD INNIDTHFIT PPLQNHHLKI KKKKINKSKK
     KKKKKKKFKY NNKSQSKVIK ELQKIIHDEN ILCKEFICKY IFKKMIKRKE KSKYHMNSKR
     TFEYIQTCTS LIIHTQDKKI KINNKNNNNN NNNNNNNNNN NNNNNIVYTY PCDVIPSSYN
     NHSVDQNHLN PHLKGTLESP VLLNVEHCFI TINNENLTKK EELKYKMKVV YKIINDIKYN
     QCFLFINNTY EGIQVIKMLK KMNVPSYYTS SKIEHKERIQ LFKSLQENKV KIVVCTDVMS
     RGIDNIVCDL VINFDIPQSK ETYVHRSGRC GRFGNKGLCV SLCNYTDYNY LYYFKYKLKL
     NVCDFYYICK SDHRKQDDSS VQINNIKKTH EHNEQIIDTH SCGDNNHYKN YDESGSSHNI
     SNFQQINYNN IFKNGDIEKL RKIYENNIRN DYYEQNGAES LKKKKKKKIL INIKGFVFSK
     HINMNQHSYN NTFNNVYLKI YFKELFIKFK IIQHNNTCSY IFKIPIDNKN IFKNINIIQH
     ESNLILFFHF FQNINICCNY YDDHIKSEHN NKSYLYNNTY FKKEKTKNII NTTSFQTNFC
     MFFFCKSNYY ITLKLYYIFL FLFKYYKYPL RKNFYHLLIY NKYYNNNNKE QYYHDEKINN
     NISSFTNLEP LTYYLQHHNN CISDSYIYYK KKKKKKTLHK NVYNLIDEGK LYEQVKYKTN
     INKHDMFTIH NNYLSNSISY HDNLDFNLLN NNNNNNHINI NSMSLEQAII SLNMDILDKH
     MFIKLCNESK HIKCINDEIT IMKKINQYIC DQIYINVNDY QNVNILKSLF LQNHIKLYED
     S
//

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