(data stored in SCRATCH zone)

SWISSPROT: Q8IAS4_PLAF7

ID   Q8IAS4_PLAF7            Unreviewed;      2231 AA.
AC   Q8IAS4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 88.
DE   SubName: Full=Erythrocyte membrane protein 1, PfEMP1 {ECO:0000313|EMBL:CAD51286.1};
GN   ORFNames=PF3D7_0808700 {ECO:0000313|EMBL:CAD51286.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51286.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51286.1; -; Genomic_DNA.
DR   RefSeq; XP_001349437.1; XM_001349401.1.
DR   SMR; Q8IAS4; -.
DR   EnsemblProtists; CAD51286; CAD51286; PF3D7_0808700.
DR   GeneDB; PF3D7_0808700.1:pep; -.
DR   GeneID; 2655304; -.
DR   KEGG; pfa:PF3D7_0808700; -.
DR   EuPathDB; PlasmoDB:PF3D7_0808700; -.
DR   HOGENOM; HOG000115239; -.
DR   KO; K13850; -.
DR   OMA; MITSTEE; -.
DR   PhylomeDB; Q8IAS4; -.
DR   Reactome; R-PFA-114608; Platelet degranulation.
DR   Reactome; R-PFA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0020002; C:host cell plasma membrane; TAS:GeneDB.
DR   GO; GO:0020030; C:infected host cell surface knob; TAS:GeneDB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0050839; F:cell adhesion molecule binding; TAS:GeneDB.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0020033; P:antigenic variation; TAS:GeneDB.
DR   GO; GO:0098609; P:cell-cell adhesion; TAS:GeneDB.
DR   GO; GO:0020035; P:cytoadherence to microvasculature, mediated by symbiont protein; TAS:GeneDB.
DR   GO; GO:0020013; P:modulation by symbiont of host erythrocyte aggregation; TAS:GeneDB.
DR   GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR   Gene3D; 1.20.1310.20; -; 2.
DR   InterPro; IPR041480; CIDR1_gamma.
DR   InterPro; IPR004258; DBL.
DR   InterPro; IPR042202; Duffy-ag-bd_sf.
DR   InterPro; IPR008602; Duffy-antigen-binding.
DR   InterPro; IPR029211; PfEMP1_ATS.
DR   InterPro; IPR029210; PfEMP1_NTS.
DR   Pfam; PF15445; ATS; 1.
DR   Pfam; PF18562; CIDR1_gamma; 1.
DR   Pfam; PF05424; Duffy_binding; 2.
DR   Pfam; PF15447; NTS; 1.
DR   Pfam; PF03011; PFEMP; 2.
PE   4: Predicted;
DR   PRODOM; Q8IAS4.
DR   SWISS-2DPAGE; Q8IAS4.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          12..48
FT                   /note="NTS"
FT                   /evidence="ECO:0000259|Pfam:PF15447"
FT   DOMAIN          627..778
FT                   /note="PFEMP"
FT                   /evidence="ECO:0000259|Pfam:PF03011"
FT   DOMAIN          1428..1474
FT                   /note="CIDR1_gamma"
FT                   /evidence="ECO:0000259|Pfam:PF18562"
FT   DOMAIN          1495..1638
FT                   /note="PFEMP"
FT                   /evidence="ECO:0000259|Pfam:PF03011"
FT   DOMAIN          1770..2231
FT                   /note="ATS"
FT                   /evidence="ECO:0000259|Pfam:PF15445"
FT   REGION          776..954
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1024..1054
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1181..1210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1636..1761
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1888..1918
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2095..2114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          203..230
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          323..343
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          387..407
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1614..1634
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        809..846
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        847..861
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        920..935
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        936..953
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1024..1039
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1040..1054
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1191..1210
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1636..1651
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1652..1667
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1694..1719
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1725..1755
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2231 AA;  255972 MW;  9FA26F6A2913FC50 CRC64;
     MAASTTYSSA PDAKHLLDMI GKDVHDQVKK EAKERSKGEL TGQLSFASIL GERAYTTDPC
     QLIKEKRENL IGDRGERHPC GNGSGKGEDV NRFSKERVDE YDNKKMKCSY GSNGKSEGAC
     APFRRLHVCD KNIQQIKTEN ITTHNLLLDV CLAAKYEGES LKGYHEQYEV QYPSSGSTMC
     TELARSFADI GDIVRGRDLY GGSKKEKEKR KQLDDKLKKI FENIKKENNE KLKSLTDDQI
     REYWWTANRE TVWKAITCDE ENKLGGYLYF RGTCGDNEKS VTQARDKCRC KKKDNTPDDQ
     VPTYFDYVPQ YLRWFEEWGE DFCRKKKKKV ENAKKKCRGE NNDKYCSRNG CDCEKTVRAK
     GKLRYGNRCT DCLYACYPYV HWIDKKKEEF DKQVKKYDEE IKKYTKVASG SSRKTRAATI
     KYEGYEKKFY EKLKESDYGK VDKFLEKLSK DKECEKVDDE EGGKINFAEK HDNNNNDEKE
     GTFYRSKYCQ PCPYCGMKKK VPGKEWEKKN DNCTSGKLYE PKGDAEGTPI KILKSGENHD
     DIKQKIDDFC KTEDDESLYA AWKCYKHDEV QKVKREGEEE DDDEEDYKNV KAAGGLCILE
     NQKKKEEGKE KKSEKEPEQF QKTFNDFFTY WVAHMLKDSI YWRTKKIKKC LENGKTMKCR
     NGCNNDCDCF ESWVKQKKEK EWKPIKDHFG KQEDIKQETG MDPGDFLEYY LKLQFFEEVS
     EEKSQTGDED ANEKKRIKEM FDKKNQRTDK VASNEETIID FMLEEELKDA TKCKQDCEQR
     KPPGAGGGDV RSDTVPSRDP LTPGPTDGHE DSEDEEEEEE EEDEEHGPDD KEGTEENVEE
     TETVEDQVEE EKAKDNTDGK GEEEEDNQGE TTQITTQDGV NPCDIVDKLF KDDNTLTNAC
     PTKYEKGREK FPNWKCIPSG DKTDTRERAG RSRRDTSGEN TTTGSSGDTN GSVCVPSRRR
     KLYIQKLHDW AEKQVGTTQV DGKAAQGDAA SKDPKVELRN AFIQSAAVET FFLWHKYKAE
     NTKTQGGVGS LPLQTIDRNS ANGDDEDNPE KQLKEGTIPH GFLRQMFYTL GDYRDILVGK
     YVDNGKDMEE VKSNIDSFFS NGEKPDDKKG VEQRKEWWKE NAKHIWHGMI CALTYDTNTA
     SGDKHTLKQN KSLKEALWDE QKKKPKKTDN GSDYTYESVV LKEDDEGGGP RGQTSSPSSG
     EKTTLNNPKL SDFVLRPPYF RYLEEWGQNF CKERKKRLEK IEEECMEYGS RGKQKQKYSG
     DGEECEKVLV EDANIFSDLS SSCATPCRKY RKWIERKKYE FTEQYNAYGG QKNNYVNEQK
     DKCQTQSNNH DNGFCGTLEK DAAAFLNRLK NGPCKNNNDN GEEHKIDFND TKKTFKHTEY
     CGPCSEFKVK CKNGACGDSN TQKKCNGITP IDGNEIAKMI TSTEEVVMRV SDNSGNRFDG
     DLKEACNGKG IFKSIKENKW ECRNVCGYVV CKPKEGNRET ASGENKDQII TIRALVTHWV
     QNFLDDYKKI KHKISQCTKT DQGSTCQNKC QNKCKCVGEW IPKKREEWEK IRKRFLEQYK
     IENDEDFNVR SCLENFLVQI GAANAKNKVI KLSKFGNSCG CSADASAQKN DGHKDAIDCL
     LQKLQNKIDD CNKNQAQNSV ETQPSDENPA QCQDTHPDDD LLLEEEQNPK NMRPGFCPED
     DTTEQQEEEQ DTCTPAGTVK EEEEEKEEKK DKGDEEEESP SGNSAPDPPE SPSAGPNHNQ
     HPPAIPTPAT PAADPPQADE PFNRDILEKT IPFGVALALG SIAFLFLKKK TKSSVGNLFQ
     ILQIPKSDYD IPTLKSKNRY IPYKSGPYKG KTYIYMEGDS DEDKYAFMSD TTDITSSESE
     YEEMDINDIY VPGSPKYKTL IEVVLEPSGN NTTASGKNTP SDTQNDIQND GIPSSKITDN
     EWNTLKHDFI SNMLQNEPNT EPNILHDNLD NNTHPTMSRD NMEEKPFITS IHDRNLYTGE
     EYNYNVNMVN SMDDTKYVSN NVYSGIDLIN DTLSGNKHID IYDEVLKRKE NELFGTNHVK
     QTSIHSVAKL TNSDPIHKQL DLLHTWLDRH RHMCEKWNNK EELLDKLKKE WNKENNTNSS
     LTHTSNIPSG ENSIKNVLNT DVSIQIDMDN PKPKNEFTNM DTIPDKSTMD TILDDLEKYN
     EPYYYDFYKD DIYYDVNDDD KTSMDDIYVD HNNVTSNNMD VPTKMHIEMN IVNNKNEIFE
     EEYPISDIWN I
//

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