(data stored in SCRATCH zone)

SWISSPROT: Q8IAW0_PLAF7

ID   Q8IAW0_PLAF7            Unreviewed;       545 AA.
AC   Q8IAW0;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 104.
DE   RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN   ORFNames=PF3D7_0812400 {ECO:0000313|EMBL:CAD51250.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51250.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- SIMILARITY: Belongs to the importin alpha family.
CC       {ECO:0000256|PIRNR:PIRNR005673}.
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DR   EMBL; AL844507; CAD51250.1; -; Genomic_DNA.
DR   RefSeq; XP_001349401.1; XM_001349365.1.
DR   SMR; Q8IAW0; -.
DR   IntAct; Q8IAW0; 1.
DR   PRIDE; Q8IAW0; -.
DR   EnsemblProtists; CAD51250; CAD51250; PF3D7_0812400.
DR   GeneDB; PF3D7_0812400.1:pep; -.
DR   GeneID; 2655286; -.
DR   KEGG; pfa:PF3D7_0812400; -.
DR   EuPathDB; PlasmoDB:PF3D7_0812400; -.
DR   HOGENOM; HOG000167616; -.
DR   InParanoid; Q8IAW0; -.
DR   OMA; SAVCRDY; -.
DR   PhylomeDB; Q8IAW0; -.
DR   BioCyc; PLASMO:PF08_0087-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0019904; F:protein domain specific binding; IDA:GeneDB.
DR   GO; GO:0046982; F:protein heterodimerization activity; TAS:GeneDB.
DR   GO; GO:0008565; F:protein transporter activity; IBA:GO_Central.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IDA:GeneDB.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; TAS:GeneDB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR024931; Importing_su_alpha.
DR   Pfam; PF00514; Arm; 6.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
DR   PROSITE; PS51214; IBB; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8IAW0.
DR   SWISS-2DPAGE; Q8IAW0.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR005673};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transport {ECO:0000256|PIRNR:PIRNR005673, ECO:0000256|PROSITE-
KW   ProRule:PRU00561}.
FT   DOMAIN        1     52       IBB. {ECO:0000259|PROSITE:PS51214}.
FT   REPEAT      134    177       ARM. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00259}.
FT   REPEAT      177    205       ARM. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00259}.
FT   REPEAT      219    247       ARM. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00259}.
FT   COILED       16     36       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   545 AA;  61158 MW;  9BD7EAA5E569C14E CRC64;
     MDRRIEARRK EFKKNCDDTR RKREDLVVQI RKQQRECQLE SKRAMVMANI GFEENNTYNL
     NYAKGNQNDS TNDSIYNTSS NNSSNTLEML KKIPTLAIGV RSNEYVTQLN STRELRKLLS
     IEKGPPIQEV INSGVVPYIV EFLKYDDKTD LQFEAAWVIT NIASGSQEQT KVVIDNNAVP
     HLVRLLSSEK EDVCEQAVWA LGNIAGDSAE CREYVLNQNS LPLLLKILRT SHKRTLIRNA
     AWTLSNLCRG KPAPKFEIVS KALPTLAALI YNDDEEILTD ACWTLSYLSD GSNENINSVL
     DAGVAERVVE LLSHCSFLVQ TPALRTVGNI VTGDDLQTDV VVKLGAVQKL SCLLNSSKKS
     IKKEACWALS NITAGNISQI QAVIDNNVIP QLINILMKED FEVRKEAAWA ISNASSGGSE
     LQIEYLVECG AIHSLSNLLD VEDANIISVT LEGLENILEM GENKKLRDNL PTNPYVHLFE
     ECDSVHKIDA LQDRKVDNIC NKAWKILYKY FPFVINNELN NAQIPLNNVF ANTEDAVLNK
     DFTFD
//

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