(data stored in SCRATCH zone)

SWISSPROT: Q8IB03_PLAF7

ID   Q8IB03_PLAF7            Unreviewed;      1070 AA.
AC   Q8IB03;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 126.
DE   SubName: Full=Chaperone protein ClpB1 {ECO:0000313|EMBL:CAD51207.1};
GN   ORFNames=PF3D7_0816600 {ECO:0000313|EMBL:CAD51207.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51207.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000213|PDB:2P65}
RP   X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 311-496.
RA   Wernimont A.K., Lew J., Kozieradzki I., Lin Y.H., Hassanali A.,
RA   Zhao Y., Arrowsmith C.H., Edwards A.M., Weigelt J., Sundstrom M.,
RA   Bochkarev A., Hui R., Artz J.D.;
RT   "Crystal Structure of the first nucleotide binding domain of chaperone
RT   ClpB1, putative, (Pv089580) from Plasmodium Vivax.";
RL   Submitted (MAR-2007) to the PDB data bank.
RN   [4] {ECO:0000213|PDB:4XBI}
RP   X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 152-298; 300-352; 427-496
RP   AND 513-586.
RX   PubMed=26130467; DOI=10.1002/pro.2739;
RA   AhYoung A.P., Koehl A., Cascio D., Egea P.F.;
RT   "Structural mapping of the ClpB ATPases of Plasmodium falciparum:
RT   Targeting protein folding and secretion for antimalarial drug
RT   design.";
RL   Protein Sci. 24:1508-1520(2015).
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DR   EMBL; AL844507; CAD51207.1; -; Genomic_DNA.
DR   RefSeq; XP_001349358.1; XM_001349322.1.
DR   PDB; 2P65; X-ray; 1.70 A; A=310-496.
DR   PDB; 4XBI; X-ray; 2.01 A; A/B=152-298.
DR   PDBsum; 2P65; -.
DR   PDBsum; 4XBI; -.
DR   SMR; Q8IB03; -.
DR   PRIDE; Q8IB03; -.
DR   EnsemblProtists; CAD51207; CAD51207; PF3D7_0816600.
DR   GeneDB; PF3D7_0816600.1:pep; -.
DR   GeneID; 2655262; -.
DR   KEGG; pfa:PF3D7_0816600; -.
DR   EuPathDB; PlasmoDB:PF3D7_0816600; -.
DR   HOGENOM; HOG000218211; -.
DR   InParanoid; Q8IB03; -.
DR   KO; K03695; -.
DR   OMA; KRYITDH; -.
DR   PhylomeDB; Q8IB03; -.
DR   BioCyc; PLASMO:PF08_0063-MONOMER; -.
DR   EvolutionaryTrace; Q8IB03; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0020011; C:apicoplast; IDA:GeneDB.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATPase activity; IDA:GeneDB.
DR   GO; GO:0019538; P:protein metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1780.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR004176; Clp_N.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF81923; SSF81923; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q8IB03.
DR   SWISS-2DPAGE; Q8IB03.
KW   3D-structure {ECO:0000213|PDB:2P65, ECO:0000213|PDB:4XBI};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN      351    496       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      808    979       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      978   1067       ClpB_D2-small. {ECO:0000259|SMART:
FT                                SM01086}.
FT   COILED      405    425       {ECO:0000256|SAM:Coils}.
FT   COILED      679    699       {ECO:0000256|SAM:Coils}.
FT   COILED      756    776       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1070 AA;  122508 MW;  8F94614898D21E0C CRC64;
     MVNSFFFCFV IIGLIYVWDI TYSKKAKIFF NKNDIFSIKN THWDIYDKKK YFFIGNNHLK
     NEESFLPEVR KDYKSQIKEY KNSTNGIIYH NNKNRLSYTI NDQVNYDNNM TSGINKKRKV
     KDSSIHMNNS YEKNRNKNKF ALFMSDEEYT INSDDYTEKA WEAISSLNKI GEKYDSAYVE
     AEMLLLALLN DSPDGLAERI LKESGIDTQL LVQEIDDYLK KQPKMPSGFG EQKILGRTLQ
     TVLSTSKRLK KEFNDEYISI EHLLLSIISE DSKFTRPWLL KYNVNYEKVK KAVEKIRGKK
     KVTSKTPEMT YQALEKYSRD LTALARAGKL DPVIGRDNEI RRAIQILSRR TKNNPILLGD
     PGVGKTAIVE GLAIKIVQGD VPDSLKGRKL VSLDMSSLIA GAKYRGDFEE RLKSILKEVQ
     DAEGQVVMFI DEIHTVVGAG AVAEGALDAG NILKPMLARG ELRCIGATTV SEYRQFIEKD
     KALERRFQQI LVEQPSVDET ISILRGLKER YEVHHGVRIL DSALVQAAVL SDRYISYRFL
     PDKAIDLIDE AASNLKIQLS SKPIQLENIE KQLIQLEMEK ISILGDKQKN LFNYSSVANT
     HNNNNNSSIS SNNSSSYGNA EETEATVDYT KSPNFLKKRI NEKEIDRLKM IDRIMSELRK
     EQRKILDSWS TEKSYVDNIR AIKERIDVVK IEIEKAERYF DLNRAAELRF ETLPDLEKQL
     KKAEENYLND IPEKSRILKD EVTSEDIVNI VSMSTGIRLN KLLKSEKEKI LNLENELHKQ
     IIGQDDAVKV VTKAVQRSRV GMNNPKRPIA SLMFLGPTGV GKTELSKVLA DVLFDTPEAV
     IHFDMSEYME KHSISKLIGA APGYVGYEQG GLLTDAVRKK PYSIILFDEI EKAHPDVYNL
     LLRVIDEGKL SDTKGNVANF RNTIIIFTSN LGSQSILDLA NDPNKKEKIK EQVMKSVRET
     FRPEFYNRID DHVIFDSLSK KELKEIANIE IRKVANRLFD KNFKITIDDA VFSYIVDKAY
     DPSFGARPLK RVIQSEIETE IAVRILDETF VENDTINISL KDQKLHFSKS
//

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