(data stored in SCRATCH zone)

SWISSPROT: Q8IB64_PLAF7

ID   Q8IB64_PLAF7            Unreviewed;      1332 AA.
AC   Q8IB64;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   08-MAY-2019, entry version 99.
DE   SubName: Full=Serine/threonine protein kinase VPS15, putative {ECO:0000313|EMBL:CAD51143.1};
GN   ORFNames=PF3D7_0823000 {ECO:0000313|EMBL:CAD51143.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51143.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51143.1; -; Genomic_DNA.
DR   RefSeq; XP_001349294.1; XM_001349258.1.
DR   PRIDE; Q8IB64; -.
DR   EnsemblProtists; CAD51143; CAD51143; PF3D7_0823000.
DR   GeneDB; PF3D7_0823000.1:pep; -.
DR   GeneID; 2655383; -.
DR   KEGG; pfa:PF3D7_0823000; -.
DR   EuPathDB; PlasmoDB:PF3D7_0823000; -.
DR   HOGENOM; HOG000282629; -.
DR   InParanoid; Q8IB64; -.
DR   OMA; DGEKNYN; -.
DR   Reactome; R-PFA-1660516; Synthesis of PIPs at the early endosome membrane.
DR   Reactome; R-PFA-5668599; RHO GTPases Activate NADPH Oxidases.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0071561; C:nucleus-vacuole junction; IBA:GO_Central.
DR   GO; GO:0034271; C:phosphatidylinositol 3-kinase complex, class III, type I; IBA:GO_Central.
DR   GO; GO:0034272; C:phosphatidylinositol 3-kinase complex, class III, type II; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0030242; P:autophagy of peroxisome; IBA:GO_Central.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR   GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR   GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
DR   PRODOM; Q8IB64.
DR   SWISS-2DPAGE; Q8IB64.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Kinase {ECO:0000313|EMBL:CAD51143.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:CAD51143.1};
KW   Transferase {ECO:0000313|EMBL:CAD51143.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    136    156       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       40    280       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
SQ   SEQUENCE   1332 AA;  162313 MW;  8C40344112DBEB28 CRC64;
     MGNTLYSNIG HSTTELDDVY CKYLNKLFNI YNYLFKYEHF FFMNSYTLNN FYHVLEGINN
     NEGHVLIKIC KLKSEAPKIK RILYTLKFLF SFDLFPNVLP YNRMSVYENN IYIYRRFIFK
     NLDHYLSNKI NTNNFYYFYI FQIFLSIIQL HSLGIYHGHI KRENVLIQNN MHIFLTDINI
     LNDYLYFIPK IRYEDERKGR LMKLQEDIFN LGILILEILL RDKDVSYFFL NENCAYKNDD
     NFYSGRRKQS GLTFLKKMES IDEDDKNDVE NYHHDSNDYH HNENYYNMNQ HYDYHSDNYY
     KCNRSNYKEE YTNDENKKNG EYQKKYVHAL SLPSIKKKKK QIKNEEYPYF NKNQNIKMNI
     DKYKYYNYHY INNVNYINIY NDIYNNVSPF SSIDYNGENI FYENDSNFFK RQPIKYSNTH
     NIKEQLNDDF QENIKYNDKN IYRQKQNEQV TQKKSQGINI YNVTDLFDDN KDDKYNTGGG
     DENDNHGNKN DNRGNKNDND GEKNYNDGEK NYNDGEKNYN DGEKNYNDGE KNYNDGEKNY
     NDGDKNNISN NADIYYNNLH NSNYYNNVYT KKTPNKIKKN DHKDPHMVPY KIWKVVNQVK
     NPLIIYSLIN HFFSYKNNNK NILKIFNYWS YYIFPSTYKY IFFPLSILQL HPLFKNSDFF
     ILLLHFNLPF ILFHLDLFSN KEQDKYILLN MLNRRNNKSG YVSTGKGSDP AYEKSDNDDD
     DDDDDNNNYN NYNNNNNNNN NNYYYNYHYD DYGNNVRNNH HIGTYLGRLN YYFNIVRTHT
     TSINKHQMKA YIINTNINNQ IKKQILKQWH SYKKEKKQEY AQYVVNNKNN VHHNIYIHKK
     TINNNNNYNN NNNYNNKRSY HSLSYFPFPI LSYKNVHAFY KNFLNFYQFL YYSIFYEHKS
     YMDVFKCMEY YKREIYSPLF NDFYYKQDRK KKETSMMNNM PMKRDLGNEI FACANNIQSN
     KIHLKKKGKK ETCNYINNNN KERNNNEHNN NNNPRANENV VRWQFNEDIC QLINIIICCY
     NSLTYNFVKM LTIEIIYCII LHISENRLNN ELISFLLYCF NKENEKIKIM VIKCFYKIIN
     NSMNNRPNMQ LYIEKFLPKY YLLKNQDIYE KYYYSKYLPL FSYITIQYIY NESLLKNNIT
     KQKKNTLSQI PYMEILNDIK TEIQFILNTQ QNYYENLFEF YNHIFPFCKI MNKKWVKIYI
     LPYLLTNIYK SKNNFIKASC AKVTLKIVFY INQKKVYHIF LQYLNKLLFS QNEQIIEFLL
     CELNHILKKT WQKYKQEQKK SKKFWIFLKK IQLDHLYIHP SIIIQQLVDK IKNKLKNIEY
     RTTNKNNKMI FM
//

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