(data stored in SCRATCH zone)

SWISSPROT: Q8IB67_PLAF7

ID   Q8IB67_PLAF7            Unreviewed;      1465 AA.
AC   Q8IB67;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 2.
DT   08-MAY-2019, entry version 106.
DE   SubName: Full=Histone acetyltransferase GCN5 {ECO:0000313|EMBL:CAD51140.2};
DE            EC=2.3.1.48 {ECO:0000313|EMBL:CAD51140.2};
GN   ORFNames=PF3D7_0823300 {ECO:0000313|EMBL:CAD51140.2};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51140.2, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000213|PDB:4QNS}
RP   X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 1356-1460.
RA   Fonseca M., Tallant C., Knapp S., Loppnau P., Hui R., Wernimont A.K.,
RA   Arrowsmith C.H., Edwards A.M., Bountra C.;
RT   "Crystal structure of bromodomain from Plasmodium faciparum GCN5,
RT   PF3D7_0823300.";
RL   Submitted (JUN-2014) to the PDB data bank.
RN   [4] {ECO:0000213|PDB:5TPX}
RP   X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 1356-1460.
RX   PubMed=27966810; DOI=10.1002/anie.201610816;
RA   Moustakim M., Clark P.G., Trulli L., Fuentes de Arriba A.L.,
RA   Ehebauer M.T., Chaikuad A., Murphy E.J., Mendez-Johnson J.,
RA   Daniels D., Hou C.D., Lin Y.H., Walker J.R., Hui R., Yang H.,
RA   Dorrell L., Rogers C.M., Monteiro O.P., Fedorov O., Huber K.V.,
RA   Knapp S., Heer J., Dixon D.J., Brennan P.E.;
RT   "Discovery of a PCAF Bromodomain Chemical Probe.";
RL   Angew. Chem. Int. Ed. 56:827-831(2017).
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DR   EMBL; AL844507; CAD51140.2; -; Genomic_DNA.
DR   RefSeq; XP_001349291.2; XM_001349255.2.
DR   PDB; 4QNS; X-ray; 1.50 A; A/B/C/D=1356-1460.
DR   PDB; 5TPX; X-ray; 2.10 A; A=1356-1460.
DR   PDBsum; 4QNS; -.
DR   PDBsum; 5TPX; -.
DR   SMR; Q8IB67; -.
DR   IntAct; Q8IB67; 22.
DR   PRIDE; Q8IB67; -.
DR   EnsemblProtists; CAD51140; CAD51140; PF3D7_0823300.
DR   GeneDB; PF3D7_0823300.1:pep; -.
DR   GeneID; 2655485; -.
DR   KEGG; pfa:PF3D7_0823300; -.
DR   EuPathDB; PlasmoDB:PF3D7_0823300; -.
DR   InParanoid; Q8IB67; -.
DR   KO; K06062; -.
DR   OMA; MASHINR; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB.
DR   GO; GO:0010484; F:H3 histone acetyltransferase activity; IDA:GeneDB.
DR   GO; GO:0043966; P:histone H3 acetylation; IDA:GeneDB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:GeneDB.
DR   Gene3D; 1.20.920.10; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR037800; GCN5.
DR   InterPro; IPR000182; GNAT_dom.
DR   PANTHER; PTHR45750; PTHR45750; 2.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q8IB67.
DR   SWISS-2DPAGE; Q8IB67.
KW   3D-structure {ECO:0000213|PDB:4QNS, ECO:0000213|PDB:5TPX};
KW   Acyltransferase {ECO:0000313|EMBL:CAD51140.2};
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035,
KW   ECO:0000256|SAAS:SAAS00979529}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transferase {ECO:0000313|EMBL:CAD51140.2}.
FT   DOMAIN     1131   1284       N-acetyltransferase.
FT                                {ECO:0000259|PROSITE:PS51186}.
FT   DOMAIN     1373   1443       Bromo. {ECO:0000259|PROSITE:PS50014}.
FT   COILED      144    164       {ECO:0000256|SAM:Coils}.
FT   COILED      886    914       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1465 AA;  170918 MW;  A95FED5C0930F78F CRC64;
     MDYLIRNNEY CNVLYDGNEL LRKRKINFDN EICPYKMNYW NNYNNNINID NDNMNNEIVN
     EEFENTYNNI NNNMYYLLGK EDMDEPRLCN KKRNVYNENF KNNLEYDENV NNYDNDNSSN
     ISYKFINNEC DKMKKSGEGT QENNDNENNN NDESNNNNNN NNNESNNNNN NNESNNNNNN
     NNNNESNNNN NNNESNNNNH GNNNNSSNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
     DKNEDDENTT GKGKKTEVKK RAGRKRNDST MYANSNTMLK NNFLQNNKMI YNNMDHINDT
     NEQDKFLYEQ RKMMMNNKME NMGPNMNMTN KNYFQTVNNM KMNVENNKNL IGINTNNMNN
     YQNNINSINT NMNIPKNKNL HSNKQMMFMN NNMNIHGKTN KLNDMARMNS INFNEENKMS
     VMNDDTRMDN KMRDIMKSGG MEVHLKNEES LYMNNMYNMN SNNPNNIPRI STMNIAKPMN
     NFNNMNMPIN NMNAYNNHMI NSYNNMMMTN NMNNINNINN INHINNNNNS NNNNNSNNSN
     NNINFGQHIQ GVQFMNPNMN NDMNSNMNNI NNNQMFLNNN QNNAHVHMVN NMNLNPSGNN
     SFFNNSNKHL NMMTMSSKNK KNAILKNTEN NEFENIKRVH SNSSNYNNNN NNNSDSNNKK
     SIKMNSNENN NTTTTIIKNI RVENIKFNES VNLKNIDGLD LSTNFVNGKY ISKLNNDEKI
     YNVVHSIVKD SLKDCLVDFY NNANYIFKDK LDFVCNSNTP TCNNINDLED NKKDDGHVDK
     QNYSLEKKDN EEHTNNNSDP IMDGVELDVK KISEKKEDQI EKDKPKNDNT KNDNTKEDKN
     QNDDNKTNTS IPKTPKNEVK NVITSSLLSS FNIFSAFSNS NTPNSKKNKY DEEEEKEEKE
     EEEENNKCND KDDEDKNKSP QNEDNKNITN DNNDNNNNNV DKENNLKESI DNLGNVDTDN
     NIKRDVLNYN NIEENEQSRE YILIEITKSI CSIINLQQLM PVNTRLANPN LIYDPNYETI
     YSKWKTFLRK EQSSGNLISN CFSRDFLHTI LLCNYVTIIE DLRKTAVKKK LKYFFLHLCL
     ESGISINVAL MLFINATKQS DKLQSLLPSE TGLGYLHRDA GGAKEENMGI ITFECITNDR
     EPDHLIKLIT LKNIFSRQLP KMPREYIVRL VFDRNHYTFC LLKKNTVIGG VCFRPYFEQK
     FAEIAFLAVT STEQVKGYGT RLMNHLKEHV KKFGIEYFLT YADNFAIGYF RKQGFSQKIS
     MPKERWFGYI KDYDGGTLME CYIFPNINYL RLSEMLYEQK KAVKKAIHFI KPQVIYKGIN
     YFADNKGAAL HPSTIPGLLE VGWKKETREI TKKVQHKEVQ LKDQILGVLD YLEKQQSAWP
     FLKPVSLSEA PDYYDIIKEP TDILTMRRKA RHGDYKTKED FGIELKRMFD NCRLYNAPTT
     IYFKYANELQ TLIWPKYEAI TDTAK
//

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