(data stored in SCRATCH zone)

SWISSPROT: Q8IB73_PLAF7

ID   Q8IB73_PLAF7            Unreviewed;       318 AA.
AC   Q8IB73;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 112.
DE   SubName: Full=Dicarboxylate/tricarboxylate carrier {ECO:0000313|EMBL:CAD51134.1};
GN   ORFNames=PF3D7_0823900 {ECO:0000313|EMBL:CAD51134.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51134.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000256|RuleBase:RU000488, ECO:0000256|SAAS:SAAS00548220}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL844507; CAD51134.1; -; Genomic_DNA.
DR   RefSeq; XP_001349285.1; XM_001349249.1.
DR   TCDB; 2.A.29.2.10; the mitochondrial carrier (mc) family.
DR   SwissPalm; Q8IB73; -.
DR   PRIDE; Q8IB73; -.
DR   EnsemblProtists; CAD51134; CAD51134; PF3D7_0823900.
DR   GeneDB; PF3D7_0823900.1:pep; -.
DR   GeneID; 2655481; -.
DR   KEGG; pfa:PF3D7_0823900; -.
DR   EuPathDB; PlasmoDB:PF3D7_0823900; -.
DR   HOGENOM; HOG000165139; -.
DR   InParanoid; Q8IB73; -.
DR   KO; K15104; -.
DR   OMA; FLHTPFM; -.
DR   PhylomeDB; Q8IB73; -.
DR   BioCyc; PLASMO:PF08_0031-MONOMER; -.
DR   Reactome; R-PFA-70263; Gluconeogenesis.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IDA:GeneDB.
DR   GO; GO:0005310; F:dicarboxylic acid transmembrane transporter activity; ISS:GeneDB.
DR   GO; GO:0015367; F:oxoglutarate:malate antiporter activity; IDA:GeneDB.
DR   GO; GO:0015742; P:alpha-ketoglutarate transport; ISS:GeneDB.
DR   GO; GO:0006835; P:dicarboxylic acid transport; ISS:GeneDB.
DR   GO; GO:0015743; P:malate transport; IDA:GeneDB.
DR   GO; GO:0006839; P:mitochondrial transport; ISS:GeneDB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
DR   PRODOM; Q8IB73.
DR   SWISS-2DPAGE; Q8IB73.
KW   Membrane {ECO:0000256|PROSITE-ProRule:PRU00282,
KW   ECO:0000256|SAAS:SAAS00013463, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00282,
KW   ECO:0000256|RuleBase:RU000488, ECO:0000256|SAAS:SAAS00423777,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00423880,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000488}.
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REPEAT          29..116
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          124..215
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          222..313
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ   SEQUENCE   318 AA;  35387 MW;  3A4D7935719271E5 CRC64;
     MDRDIAKYDL ESSSSVDVNK KGNNNKSVFE KIKPFAVGGA SGMFATFCIQ PLDMVKVRIQ
     LNAEGKNVLR NPFIVAKDII KNEGFLSLYK GLDAGLTRQV IYTTGRLGLF RTFSDMVKKE
     GEPLPFYKKC FCALAAGGLG AFIGNPADLS LIRLQADNTL PKELKRNYTG VFNALYRISK
     EEGLFALWKG SVPTIARAMS LNLGMLSTYD QSKEFLQKYL GVGMKTNLVA SVISGFFAVT
     LSLPFDFVKT CMQKMKADPV TKKMPYKNML DCSIQLYKKG GISIFYSSYA TYYVRIAPHA
     MITLITVDYL NNLLKKIS
//

If you have problems or comments...

PBIL Back to PBIL home page