(data stored in SCRATCH zone)

SWISSPROT: Q8IB75_PLAF7

ID   Q8IB75_PLAF7            Unreviewed;       406 AA.
AC   Q8IB75;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 90.
DE   SubName: Full=Exonuclease, putative {ECO:0000313|EMBL:CAD51132.1};
DE            EC=3.1.11.1 {ECO:0000313|EMBL:CAD51132.1};
DE            EC=3.1.11.2 {ECO:0000313|EMBL:CAD51132.1};
GN   ORFNames=PF3D7_0824100 {ECO:0000313|EMBL:CAD51132.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51132.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAD51132.1; -; Genomic_DNA.
DR   RefSeq; XP_001349283.1; XM_001349247.1.
DR   EnsemblProtists; CAD51132; CAD51132; PF3D7_0824100.
DR   GeneDB; PF3D7_0824100.1:pep; -.
DR   GeneID; 2655376; -.
DR   KEGG; pfa:PF3D7_0824100; -.
DR   EuPathDB; PlasmoDB:PF3D7_0824100; -.
DR   HOGENOM; HOG000282618; -.
DR   InParanoid; Q8IB75; -.
DR   OMA; EKYYIFD; -.
DR   BioCyc; PLASMO:MAL8P1.35-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0008852; F:exodeoxyribonuclease I activity; IEA:UniProtKB-EC.
DR   GO; GO:0008853; F:exodeoxyribonuclease III activity; IEA:UniProtKB-EC.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   4: Predicted;
DR   PRODOM; Q8IB75.
DR   SWISS-2DPAGE; Q8IB75.
KW   Exonuclease {ECO:0000313|EMBL:CAD51132.1};
KW   Hydrolase {ECO:0000313|EMBL:CAD51132.1};
KW   Nuclease {ECO:0000313|EMBL:CAD51132.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          79..272
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00474"
SQ   SEQUENCE   406 AA;  48101 MW;  C2C5254587FA67B9 CRC64;
     MNLFNYTHNY IYIIKYKNFY HNLLNIEFFK HFKSIEKFGL LKRFYSTKFN SKEYEKYDRN
     NNDKKCIILR NTESVSKDIK IIENEKECEE AAEEINRSEI IAIDFEGTNL GRYGKVCLMQ
     VYVEKKNMNE QSDNILQKYY IFDLLKTSVI KSAQKIIENK KTLKLIHDCR EDSSALYNQL
     GMKLENVYDT SRAHLLLMEK QKKNDIYQVS FAQLINDYLG INDASLSFIK KEMYKNEKIW
     ETRPLSNISI IYALKNVKYL YKLYKIFDKL LPKKLVLEKS KEFVNYCYLN YEYKLPNDLA
     KRGNIVEAML VSKSLLNCVF KLNSTRKGMA CTPSTIAHFV DVKIGDVVLC VVSNKSIDQK
     ILYLCKHDDV YDYWNLKERP REKFKPSIHE CTTDPMITFC NEEHSS
//

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