(data stored in SCRATCH zone)

SWISSPROT: Q8IBB0_PLAF7

ID   Q8IBB0_PLAF7            Unreviewed;      2399 AA.
AC   Q8IBB0;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   11-DEC-2019, entry version 110.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|SAAS:SAAS00591749};
DE            EC=2.1.1.43 {ECO:0000256|SAAS:SAAS00591749};
GN   ORFNames=PF3D7_0827800 {ECO:0000313|EMBL:CAD51097.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51097.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-
CC         methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929;
CC         Evidence={ECO:0000256|SAAS:SAAS01127263};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
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DR   EMBL; AL844507; CAD51097.1; -; Genomic_DNA.
DR   RefSeq; XP_001349248.1; XM_001349212.1.
DR   SMR; Q8IBB0; -.
DR   PRIDE; Q8IBB0; -.
DR   EnsemblProtists; CAD51097; CAD51097; PF3D7_0827800.
DR   GeneDB; PF3D7_0827800.1:pep; -.
DR   GeneID; 2655461; -.
DR   KEGG; pfa:PF3D7_0827800; -.
DR   EuPathDB; PlasmoDB:PF3D7_0827800; -.
DR   InParanoid; Q8IBB0; -.
DR   OMA; DMKNMED; -.
DR   BioCyc; PLASMO:PF08_0012-MONOMER; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0034399; C:nuclear periphery; IDA:GeneDB.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
DR   PRODOM; Q8IBB0.
DR   SWISS-2DPAGE; Q8IBB0.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Methyltransferase {ECO:0000313|EMBL:CAD51097.1};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000313|EMBL:CAD51097.1}.
FT   DOMAIN          2252..2379
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          2383..2399
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          84..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          173..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          467..505
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          551..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1107..1156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1298..1354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1562..1629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1521..1541
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        190..236
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        262..276
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..300
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..333
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..374
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..486
FT                   /note="Basic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        487..504
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1582..1624
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2399 AA;  283548 MW;  9C460E0249AA549D CRC64;
     MLNDMNDKKD SIRNRNYKKN KKDEERNIRK YSNDNINVVN NMKDIYNNNN NNINKSVIDC
     GNNLKRIEGK KVFERNKFGQ FIKKSNSPSL KDTNIKSNNN KNMKNTNHNN EENNNNNNTN
     NTLSNKEKIK VLIDKMKKIQ NKKEVNKTLD KPMYIRNFQD EKKVSTHNNA YKLKRNGDPR
     NYGDIKNGDN IKNGDNNKNG DNIKNGDNIK NGDNIKNGDN IKNGDNIKNG DNIKNGDNIK
     NGDDQIIGCL KNNREPRSNV ENETNEMSNS YGKFTKNRDL KNSDKIKMND EYRRNNDANI
     SDYNKKNNNN NVNKSNNVVR SSDESLSSDT INKSDCKNKV EENSSRNADE SHKKEDGDLI
     NKDKDEKEGE NLSVPKESNE TYYRISRRER CRNLKKEDNL KIINDEDNSV SHFIKEGRKR
     SVRERSNLRN YNYINVNNNI KDDDFVDEPN NGSSIIKMNE RKKTILRRGA RHRRRNPRKR
     GRRCSSLRNN RNTINSVTKS NYDMSDGDNY EKGRKFLYDN SSNYNELDPL NSKFSNIKIS
     KNFFLKMNDD EDEEDEDGVG DDDKTSKNSS YSFGFNERNI EKKIIILEQK DGIYEINENY
     LKYDNMKDME DRKNMEDMKN MEDRKNMEDM KNMEYMKNME YMKNMEYMKN MEDMKNMEDM
     KNMEDMKNME DMKNMEDMKN MEDDNKKDYM NDNLKDDIVI KDNIVIKDDI VMKDNIVMKD
     NINDSVKDNI NEELENNETS CKSSKLNDVT HNNNNICDDN NIVSHSNGEM KEVNIMYPIN
     NEINIKKKRI LNNDEILILL NLLRDININR FNIKHVMTSK DCMYEKFMLY NLFSYNITCL
     KSSLKMMYAY CLFKNLKLFY QIQYKNMNMT EKSIPNYKIK NNLLDTHCII LSMFENYYEN
     VSKQKMPIAD FINSFYLNIH NINIGKKKVQ PNKNYENIVL PEKDNRKITS MYTNKSLLYS
     NYMNKDINME NKAYKLNDIN MENYRSDHKN NTFIDNDCNN NHKYNNICKN ELNSCISNIS
     NDPNNNKNVH TMNKDLYGNI YTEQNAYHVH NYKDMRNEHE NNNNIKKKDN IENSIYYDNK
     MYLGANEKTP CLKDIHMNKN YEQTYDNYDG TNGYNNNNKK KNDNKKNDNN NNDNNNNDNN
     NNDNQDDNHH DNNKEEYNNQ NHLFLNNESR KRKFFTNILP YKNKKKKLPY TINLNNDNKT
     YHHESINNEN HMPLWDYKEL ENIKNMINDE KDEEDCTPLA HSIKITKNYD NINMDECNVR
     NENQEYKDNV TNYKVCQDGN FECYDVNESV LVRDIHMEKN NNVEKNNNDE KKNNDEKKNN
     DEKKNNDEKK NNDEKKNNDE KKNNDEKNND DNNNIIEKAK ENIESIPYDK NCSQDNIQYN
     MAYKDTSLLL CEQRDMDKGN KKEDDTIKME DIHFSADMEC SPMLKYRKRN YDNKNDDDYV
     KNDDDYVKDD DGCVKNDDGC IKNDDGYIKN DDGYIKNDDG YIKNDDDYNN NGEYLHGSDN
     NLSAHKYNSV CRRRRRVDRN KESNEKEKRV YRNDIMELEN VDVMLLERIK KNYKMLIRND
     NENKKKKKKN NGTVTILEDV DNVYDDNNNN NNDNNIDNNN NNNNNNNNNN NNNNVESHNN
     NNNERGSTKI EKCRKNKITF FNKYSKLLNN DNVDKKKSKY MLTTESLYNN NFNILDIKVN
     THFAHNYHIS LFFFCKYTSY NLYLHPLNKN EHIVSYVILN SKNEVLTDNG NSFVLRYLLS
     FLTNKISSLR KCYANALYNS YLLQIPIRIF RHHNLENKYS PQYGIRYDGI YKIINAFTIN
     DYSTPEYKRD ILYVFKRLYV DKCFIPNMNP KILDKQDKAE RKKNFIEKNS VSINVMMNKE
     IIMTLRIPYL KNYKSTTFTN FNHIYKFIKK KCIQKKKAMP WIQSEVSIYE ACMQHIKKTE
     EKKKEHFLNS QKMNNIKTKV NNTNDIYNNE NLNSGDDAFK DCIQAINVDK SVQQINDVRF
     DMNDGNYKMG DIKKECSNVY ENMFPAKNNN KIDINKININ SNHFSNSSNN NNCDNYKRLG
     EPNFPYWCLG KYLPFVLVLE TLNFEKEIDI YKGIRTKNLK NLKISIIKTE IPINCEMAKR
     PAHLFIPIKS KEAISAYIEL KKPYDNHWNP YEDLSGGKEI FKIPVENVVD ESLPPMNFTY
     VNKTIFFSRL PPYNLLPLCS GCAPHNYNKK EYVDLYINGY CKGIRHKKTN RIYCDGNKNY
     DINDFNVLAA CSGNCLCDPL KCTNKFPEGL HYPIKVVKTK DIGWDIVSCS FIKANSLIMH
     YVGEITTRKE MISREHEYDK KGYFNYFIET AEVDETYPDD WKIPCIDALF ISNVARFLNH
     SCEPNVNVIT IWRGDNYPSV GIFASRDIQP NEPLKYHYGI NYKNIKCMCA SKKCKGYIG
//

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