(data stored in ACNUC7820 zone)

SWISSPROT: OR7G2_HUMAN

ID   OR7G2_HUMAN             Reviewed;         324 AA.
AC   Q8NG99; Q6IFJ4; Q96RA0;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   30-AUG-2017, entry version 119.
DE   RecName: Full=Olfactory receptor 7G2;
DE   AltName: Full=OST260;
DE   AltName: Full=Olfactory receptor 19-13;
DE            Short=OR19-13;
DE   AltName: Full=Olfactory receptor OR19-6;
GN   Name=OR7G2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DAA04666.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
CC       (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7G2";
DR   EMBL; AB065927; BAC06142.1; -; Genomic_DNA.
DR   EMBL; AC011464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF399539; AAK95024.1; -; Genomic_DNA.
DR   EMBL; BK004268; DAA04666.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_001005193.1; NM_001005193.1.
DR   UniGene; Hs.553774; -.
DR   ProteinModelPortal; Q8NG99; -.
DR   STRING; 9606.ENSP00000303822; -.
DR   BioMuta; OR7G2; -.
DR   DMDM; 38372649; -.
DR   PaxDb; Q8NG99; -.
DR   PRIDE; Q8NG99; -.
DR   Ensembl; ENST00000305456; ENSP00000303822; ENSG00000170923.
DR   GeneID; 390882; -.
DR   KEGG; hsa:390882; -.
DR   UCSC; uc010xkk.2; human.
DR   CTD; 390882; -.
DR   GeneCards; OR7G2; -.
DR   HGNC; HGNC:8466; OR7G2.
DR   neXtProt; NX_Q8NG99; -.
DR   eggNOG; ENOG410IVB1; Eukaryota.
DR   eggNOG; ENOG410YBQN; LUCA.
DR   HOGENOM; HOG000041364; -.
DR   HOVERGEN; HBG017625; -.
DR   InParanoid; Q8NG99; -.
DR   KO; K04257; -.
DR   OrthoDB; EOG091G0B53; -.
DR   PhylomeDB; Q8NG99; -.
DR   TreeFam; TF337210; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   GeneWiki; OR7G2; -.
DR   GenomeRNAi; 390882; -.
DR   PRO; PR:Q8NG99; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   CleanEx; HS_OR7G2; -.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8NG99.
DR   SWISS-2DPAGE; Q8NG99.
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
KW   Polymorphism; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    324       Olfactory receptor 7G2.
FT                                /FTId=PRO_0000150651.
FT   TOPO_DOM      1     25       Extracellular. {ECO:0000255}.
FT   TRANSMEM     26     46       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     47     54       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     55     75       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     76     99       Extracellular. {ECO:0000255}.
FT   TRANSMEM    100    120       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    121    139       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    140    160       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    161    197       Extracellular. {ECO:0000255}.
FT   TRANSMEM    198    217       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    218    237       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    238    258       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    259    271       Extracellular. {ECO:0000255}.
FT   TRANSMEM    272    292       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    293    324       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD      5      5       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     89     89       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     97    189       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   VARIANT     281    281       F -> V (in dbSNP:rs4804401).
FT                                /FTId=VAR_024113.
FT   CONFLICT    271    271       T -> A (in Ref. 3; AAK95024).
FT                                {ECO:0000305}.
SQ   SEQUENCE   324 AA;  35931 MW;  C08808B72ABE34FC CRC64;
     MEARNQTAIS KFLLLGLIED PELQPVLFSL FLSMYLVTIL GNLLILLAVI SDSHLHTPMY
     FFLSNLSFLD ICLSTTTIPK MLVNIQAQNR SITYSGCLTQ ICFVLFFAGL ENCLLAAMAY
     DRYVAICHPL RYTVIMNPRL CGLLILLSLL TSVVNALLLS LMVLRLSFCT DLEIPLFFCE
     LAQVIQLTCS DTLINNILIY FAACIFGGVP LSGIILSYTQ ITSCVLRMPS ASGKHKAVST
     CGSHLSIVLL FYGAGLGVYI SSVVTDSPRK TAVASVMYSV FPQMVNPFIY SLRNKDMKGT
     LRKFIGRIPS LLWCAICFGF RFLE
//

If you have problems or comments...

PBIL Back to PBIL home page